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Pathways of precipitation formation in different thermodynamic and aerosol environments over the Indian Peninsula 期刊论文
Atmospheric Research, 2021
作者:  K. Gayatri, S. Patade, J. Fan, T. Prabhakaran
收藏  |  浏览/下载：20/0  |  提交时间：2021/11/30
Peta–electron volt gamma-ray emission from the Crab Nebula 期刊论文
Science, 2021
作者:  The LHAASO Collaboration*†;  Zhen Cao;  F. Aharonian;  Q. An;  Axikegu;  L. X. Bai;  Y. X. Bai;  Y. W. Bao;  D. Bastieri;  X. J. Bi;  Y. J. Bi;  H. Cai;  J. T. Cai;  Zhe Cao;  J. Chang;  J. F. Chang;  B. M. Chen;  E. S. Chen;  J. Chen;  Liang Chen;  Liang Chen;  Long Chen;  M. J. Chen;  M. L. Chen;  Q. H. Chen;  S. H. Chen;  S. Z. Chen;  T. L. Chen;  X. L. Chen;  Y. Chen;  N. Cheng;  Y. D. Cheng;  S. W. Cui;  X. H. Cui;  Y. D. Cui;  B. D’Ettorre Piazzoli;  B. Z. Dai;  H. L. Dai;  Z. G. Dai;  Danzengluobu;  D. della Volpe;  X. J. Dong;  K. K. Duan;  J. H. Fan;  Y. Z. Fan;  Z. X. Fan;  J. Fang;  K. Fang;  C. F. Feng;  L. Feng;  S. H. Feng;  Y. L. Feng;  B. Gao;  C. D. Gao;  L. Q. Gao;  Q. Gao;  W. Gao;  M. M. Ge;  L. S. Geng;  G. H. Gong;  Q. B. Gou;  M. H. Gu;  F. L. Guo;  J. G. Guo;  X. L. Guo;  Y. Q. Guo;  Y. Y. Guo;  Y. A. Han;  H. H. He;  H. N. He;  J. C. He;  S. L. He;  X. B. He;  Y. He;  M. Heller;  Y. K. Hor;  C. Hou;  X. Hou;  H. B. Hu;  S. Hu;  S. C. Hu;  X. J. Hu;  D. H. Huang;  Q. L. Huang;  W. H. Huang;  X. T. Huang;  X. Y. Huang;  Z. C. Huang;  F. Ji;  X. L. Ji;  H. Y. Jia;  K. Jiang;  Z. J. Jiang;  C. Jin;  T. Ke;  D. Kuleshov;  K. Levochkin;  B. B. Li;  Cheng Li;  Cong Li;  F. Li;  H. B. Li;  H. C. Li;  H. Y. Li;  Jian Li;  Jie Li;  K. Li;  W. L. Li;  X. R. Li;  Xin Li;  Xin Li;  Y. Li;  Y. Z. Li;  Zhe Li;  Zhuo Li;  E. W. Liang;  Y. F. Liang;  S. J. Lin;  B. Liu;  C. Liu;  D. Liu;  H. Liu;  H. D. Liu;  J. Liu;  J. L. Liu;  J. S. Liu;  J. Y. Liu;  M. Y. Liu;  R. Y. Liu;  S. M. Liu;  W. Liu;  Y. Liu;  Y. N. Liu;  Z. X. Liu;  W. J. Long;  R. Lu;  H. K. Lv;  B. Q. Ma;  L. L. Ma;  X. H. Ma;  J. R. Mao;  A. Masood;  Z. Min;  W. Mitthumsiri;  T. Montaruli;  Y. C. Nan;  B. Y. Pang;  P. Pattarakijwanich;  Z. Y. Pei;  M. Y. Qi;  Y. Q. Qi;  B. Q. Qiao;  J. J. Qin;  D. Ruffolo;  V. Rulev;  A. Saiz;  L. Shao;  O. Shchegolev;  X. D. Sheng;  J. Y. Shi;  H. C. Song;  Yu. V. Stenkin;  V. Stepanov;  Y. Su;  Q. N. Sun;  X. N. Sun;  Z. B. Sun;  P. H. T. Tam;  Z. B. Tang;  W. W. Tian;  B. D. Wang;  C. Wang;  H. Wang;  H. G. Wang;  J. C. Wang;  J. S. Wang;  L. P. Wang;  L. Y. Wang;  R. N. Wang;  Wei Wang;  Wei Wang;  X. G. Wang;  X. J. Wang;  X. Y. Wang;  Y. Wang;  Y. D. Wang;  Y. J. Wang;  Y. P. Wang;  Z. H. Wang;  Z. X. Wang;  Zhen Wang;  Zheng Wang;  D. M. Wei;  J. J. Wei;  Y. J. Wei;  T. Wen;  C. Y. Wu;  H. R. Wu;  S. Wu;  W. X. Wu;  X. F. Wu;  S. Q. Xi;  J. Xia;  J. J. Xia;  G. M. Xiang;  D. X. Xiao;  G. Xiao;  H. B. Xiao;  G. G. Xin;  Y. L. Xin;  Y. Xing;  D. L. Xu;  R. X. Xu;  L. Xue;  D. H. Yan;  J. Z. Yan;  C. W. Yang;  F. F. Yang;  J. Y. Yang;  L. L. Yang;  M. J. Yang;  R. Z. Yang;  S. B. Yang;  Y. H. Yao;  Z. G. Yao;  Y. M. Ye;  L. Q. Yin;  N. Yin;  X. H. You;  Z. Y. You;  Y. H. Yu;  Q. Yuan;  H. D. Zeng;  T. X. Zeng;  W. Zeng;  Z. K. Zeng;  M. Zha;  X. X. Zhai;  B. B. Zhang;  H. M. Zhang;  H. Y. Zhang;  J. L. Zhang;  J. W. Zhang;  L. X. Zhang;  Li Zhang;  Lu Zhang;  P. F. Zhang;  P. P. Zhang;  R. Zhang;  S. R. Zhang;  S. S. Zhang;  X. Zhang;  X. P. Zhang;  Y. F. Zhang;  Y. L. Zhang;  Yi Zhang;  Yong Zhang;  B. Zhao;  J. Zhao;  L. Zhao;  L. Z. Zhao;  S. P. Zhao;  F. Zheng;  Y. Zheng;  B. Zhou;  H. Zhou;  J. N. Zhou;  P. Zhou;  R. Zhou;  X. X. Zhou;  C. G. Zhu;  F. R. Zhu;  H. Zhu;  K. J. Zhu;  X. Zuo
收藏  |  浏览/下载：100/0  |  提交时间：2021/07/27
Betatron cooling of electrons in Martian magnetotail 期刊论文
Geophysical Research Letters, 2021
作者:  Z. Z. Guo;  H. S. Fu;  J. B. Cao;  K. Fan;  Z. H. Yao;  Y. Y. Liu;  Z. Z. Chen;  Z. Wang;  X. Y. Liu;  Y. Xu;  C. Mazelle;  D. L. Mitchell
收藏  |  浏览/下载：45/0  |  提交时间：2021/06/24
A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon 期刊论文
Science, 2021
作者:  Zhenyu Tian;  Haoqi Zhao;  Katherine T. Peter;  Melissa Gonzalez;  Jill Wetzel;  Christopher Wu;  Ximin Hu;  Jasmine Prat;  Emma Mudrock;  Rachel Hettinger;  Allan E. Cortina;  Rajshree Ghosh Biswas;  Flávio Vinicius Crizóstomo Kock;  Ronald Soong;  Amy Jenne;  Bowen Du;  Fan Hou;  Huan He;  Rachel Lundeen;  Alicia Gilbreath;  Rebecca Sutton;  Nathaniel L. Scholz;  Jay W. Davis;  Michael C. Dodd;  Andre Simpson;  Jenifer K. McIntyre;  Edward P. Kolodziej
收藏  |  浏览/下载：26/0  |  提交时间：2021/01/15
Asymmetric responses of ecosystem productivity to rainfall anomalies vary inversely with mean annual rainfall over the conterminous United States 期刊论文
Global Change Biology, 2020
作者:  Amen Al‐;  Yaari;  Jean‐;  Pierre Wigneron;  Philippe Ciais;  Markus Reichstein;  Ashley Ballantyne;  Jerome Ogé;  e;  Agnè;  s Ducharne;  Jennifer J. Swenson;  Fré;  dé;  ric Frappart;  Lei Fan;  Lisa Wingate;  Xiaojun Li;  Koen Hufkens;  Alan K. Knapp
收藏  |  浏览/下载：23/0  |  提交时间：2020/09/30
Array programming with NumPy 期刊论文
Nature, 2020
作者:  Charles R. Harris;  K. Jarrod Millman;  Sté;  fan J. van der Walt;  Ralf Gommers;  Pauli Virtanen;  David Cournapeau;  Eric Wieser;  Julian Taylor;  Sebastian Berg;  Nathaniel J. Smith;  Robert Kern;  Matti Picus;  Stephan Hoyer;  Marten H. van Kerkwijk;  Matthew Brett;  Allan Haldane;  Jaime Ferná;  ndez del Rí;  o;  Mark Wiebe;  Pearu Peterson;  Pierre Gé;  rard-Marchant;  Kevin Sheppard;  Tyler Reddy;  Warren Weckesser;  Hameer Abbasi;  Christoph Gohlke;  Travis E. Oliphant
收藏  |  浏览/下载：36/0  |  提交时间：2020/09/22
Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain 期刊论文
Science, 2020
作者:  Alana M. Horowitz;  Xuelai Fan;  Gregor Bieri;  Lucas K. Smith;  Cesar I. Sanchez-Diaz;  Adam B. Schroer;  Geraldine Gontier;  Kaitlin B. Casaletto;  Joel H. Kramer;  Katherine E. Williams;  Saul A. Villeda
收藏  |  浏览/下载：23/0  |  提交时间：2020/07/14
Partitioning of cancer therapeutics in nuclear condensates 期刊论文
Science, 2020
作者:  Isaac A. Klein;  Ann Boija;  Lena K. Afeyan;  Susana Wilson Hawken;  Mengyang Fan;  Alessandra Dall'Agnese;  Ozgur Oksuz;  Jonathan E. Henninger;  Krishna Shrinivas;  Benjamin R. Sabari;  Ido Sagi;  Victoria E. Clark;  Jesse M. Platt;  Mrityunjoy Kar;  Patrick M. McCall;  Alicia V. Zamudio;  John C. Manteiga;  Eliot L. Coffey;  Charles H. Li;  Nancy M. Hannett;  Yang Eric Guo;  Tim-Michael Decker;  Tong Ihn Lee;  Tinghu Zhang;  Jing-Ke Weng;  Dylan J. Taatjes;  Arup Chakraborty;  Phillip A. Sharp;  Young Tae Chang;  Anthony A. Hyman;  Nathanael S. Gray;  Richard A. Young
收藏  |  浏览/下载：46/0  |  提交时间：2020/06/22
Phase Transition of Enstatite-Ferrosilite Solid Solutions at High Pressure and High Temperature: Constraints on Metastable Orthopyroxene in Cold Subduction 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Xu, Jingui;  Fan, Dawei;  Zhang, Dongzhou;  Guo, Xinzhuan;  Zhou, Wenge;  Dera, Przemyslaw K.
收藏  |  浏览/下载：31/0  |  提交时间：2020/05/13
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：25/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.