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Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity 期刊论文
Science, 2021
作者:  Ke Xu;  Na Yin;  Min Peng;  Efstathios G. Stamatiades;  Amy Shyu;  Peng Li;  Xian Zhang;  Mytrang H. Do;  Zhaoquan Wang;  Kristelle J. Capistrano;  Chun Chou;  Andrew G. Levine;  Alexander Y. Rudensky;  Ming O. Li
收藏  |  浏览/下载:30/0  |  提交时间:2021/01/28
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 期刊论文
Science, 2020
作者:  David E. Gordon;  Joseph Hiatt;  Mehdi Bouhaddou;  Veronica V. Rezelj;  Svenja Ulferts;  Hannes Braberg;  Alexander S. Jureka;  Kirsten Obernier;  Jeffrey Z. Guo;  Jyoti Batra;  Robyn M. Kaake;  Andrew R. Weckstein;  Tristan W. Owens;  Meghna Gupta;  Sergei Pourmal;  Erron W. Titus;  Merve Cakir;  Margaret Soucheray;  Michael McGregor;  Zeynep Cakir;  Gwendolyn Jang;  Matthew J. O’Meara;  Tia A. Tummino;  Ziyang Zhang;  Helene Foussard;  Ajda Rojc;  Yuan Zhou;  Dmitry Kuchenov;  Ruth Hüttenhain;  Jiewei Xu;  Manon Eckhardt;  Danielle L. Swaney;  Jacqueline M. Fabius;  Manisha Ummadi;  Beril Tutuncuoglu;  Ujjwal Rathore;  Maya Modak;  Paige Haas;  Kelsey M. Haas;  Zun Zar Chi Naing;  Ernst H. Pulido;  Ying Shi;  Inigo Barrio-Hernandez;  Danish Memon;  Eirini Petsalaki;  Alistair Dunham;  Miguel Correa Marrero;  David Burke;  Cassandra Koh;  Thomas Vallet;  Jesus A. Silvas;  Caleigh M. Azumaya;  Christian Billesbølle;  Axel F. Brilot;  Melody G. Campbell;  Amy Diallo;  Miles Sasha Dickinson;  Devan Diwanji;  Nadia Herrera;  Nick Hoppe;  Huong T. Kratochvil;  Yanxin Liu;  Gregory E. Merz;  Michelle Moritz;  Henry C. Nguyen;  Carlos Nowotny;  Cristina Puchades;  Alexandrea N. Rizo;  Ursula Schulze-Gahmen;  Amber M. Smith;  Ming Sun;  Iris D. Young;  Jianhua Zhao;  Daniel Asarnow;  Justin Biel;  Alisa Bowen;  Julian R. Braxton;  Jen Chen;  Cynthia M. Chio;  Un Seng Chio;  Ishan Deshpande;  Loan Doan;  Bryan Faust;  Sebastian Flores;  Mingliang Jin;  Kate Kim;  Victor L. Lam;  Fei Li;  Junrui Li;  Yen-Li Li;  Yang Li;  Xi Liu;  Megan Lo;  Kyle E. Lopez;  Arthur A. Melo;  Frank R. Moss;  Phuong Nguyen;  Joana Paulino;  Komal Ishwar Pawar;  Jessica K. Peters;  Thomas H. Pospiech;  Maliheh Safari;  Smriti Sangwan;  Kaitlin Schaefer;  Paul V. Thomas;  Aye C. Thwin;  Raphael Trenker;  Eric Tse;  Tsz Kin Martin Tsui;  Feng Wang;  Natalie Whitis;  Zanlin Yu;  Kaihua Zhang;  Yang Zhang;  Fengbo Zhou;  Daniel Saltzberg;  QCRG Structural Biology Consortium12†;  Anthony J. Hodder;  Amber S. Shun-Shion;  Daniel M. Williams;  Kris M. White;  Romel Rosales;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Arvind H. Patel;  Suzannah Rihn;  Mir M. Khalid;  Albert Vallejo-Gracia;  Parinaz Fozouni;  Camille R. Simoneau;  Theodore L. Roth;  David Wu;  Mohd Anisul Karim;  Maya Ghoussaini;  Ian Dunham;  Francesco Berardi;  Sebastian Weigang;  Maxime Chazal;  Jisoo Park;  James Logue;  Marisa McGrath;  Stuart Weston;  Robert Haupt;  C. James Hastie;  Matthew Elliott;  Fiona Brown;  Kerry A. Burness;  Elaine Reid;  Mark Dorward;  Clare Johnson;  Stuart G. Wilkinson;  Anna Geyer;  Daniel M. Giesel;  Carla Baillie;  Samantha Raggett;  Hannah Leech;  Rachel Toth;  Nicola Goodman;  Kathleen C. Keough;  Abigail L. Lind;  Zoonomia Consortium‡;  Reyna J. Klesh;  Kafi R. Hemphill;  Jared Carlson-Stevermer;  Jennifer Oki;  Kevin Holden;  Travis Maures;  Katherine S. Pollard;  Andrej Sali;  David A. Agard;  Yifan Cheng;  James S. Fraser;  Adam Frost;  Natalia Jura;  Tanja Kortemme;  Aashish Manglik;  Daniel R. Southworth;  Robert M. Stroud;  Dario R. Alessi;  Paul Davies;  Matthew B. Frieman;  Trey Ideker;  Carmen Abate;  Nolwenn Jouvenet;  Georg Kochs;  Brian Shoichet;  Melanie Ott;  Massimo Palmarini;  Kevan M. Shokat;  Adolfo García-Sastre;  Jeremy A. Rassen;  Robert Grosse;  Oren S. Rosenberg;  Kliment A. Verba;  Christopher F. Basler;  Marco Vignuzzi;  Andrew A. Peden;  Pedro Beltrao;  Nevan J. Krogan
收藏  |  浏览/下载:73/0  |  提交时间:2020/12/07
Atmospheric Evolution of Emissions from a Boreal Forest Fire: The Formation of Highly-Functionalized Oxygen-, Nitrogen-, and Sulfur-Containing Compounds 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Jenna C. Ditto, Megan He, Tori N. Hass-Mitchell, Samar G. Moussa, Katherine Hayden, Shao-Meng Li, John Liggio, Amy Leithead, Patrick Lee, Michael J. Wheeler, Jeremy J. B. Wenztell, and Drew R. Gentner
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/09
Horizon Scan of the Belt and Road Initiative 期刊论文
TRENDS IN ECOLOGY & EVOLUTION, 2020, 35 (7) : 583-593
作者:  Hughes, Alice C.;  Lechner, Alex M.;  Chitov, Alexander;  Horstmann, Alexander;  Hinsley, Amy;  Tritto, Angela;  Chariton, Anthony;  Li, Binbin, V;  Ganapin, Delfin;  Simonov, Eugene;  Morton, Katherine;  Toktomushev, Kemel;  Foggin, Marc;  Tan-Mullins, May;  Orr, Michael C.;  Griffiths, Richard;  Nash, Richard;  Perkin, Scott;  Glemet, Raphael;  Kim, Minsun;  Yu, Douglas W.
收藏  |  浏览/下载:31/0  |  提交时间:2020/08/18
Operation of a silicon quantum processor unit cell above one kelvin 期刊论文
NATURE, 2020, 580 (7803) : 350-+
作者:  Han, Kyuho;  Pierce, Sarah E.;  Li, Amy;  Spees, Kaitlyn;  Anderson, Grace R.;  Seoane, Jose A.;  Lo, Yuan-Hung;  Dubreuil, Michael;  Olivas, Micah;  Kamber, Roarke A.;  Wainberg, Michael;  Kostyrko, Kaja;  Kelly, Marcus R.;  Yousefi, Maryam;  Simpkins, Scott W.;  Yao, David
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/03

Quantum computers are expected to outperform conventional computers in several important applications, from molecular simulation to search algorithms, once they can be scaled up to large numbers-typically millions-of quantum bits (qubits)(1-3). For most solid-state qubit technologies-for example, those using superconducting circuits or semiconductor spins-scaling poses a considerable challenge because every additional qubit increases the heat generated, whereas the cooling power of dilution refrigerators is severely limited at their operating temperature (less than 100 millikelvin)(4-6). Here we demonstrate the operation of a scalable silicon quantum processor unit cell comprising two qubits confined to quantum dots at about 1.5 kelvin. We achieve this by isolating the quantum dots from the electron reservoir, and then initializing and reading the qubits solely via tunnelling of electrons between the two quantum dots(7-9). We coherently control the qubits using electrically driven spin resonance(10,11) in isotopically enriched silicon(12 28)Si, attaining single-qubit gate fidelities of 98.6 per cent and a coherence time of 2 microseconds during '  hot'  operation, comparable to those of spin qubits in natural silicon at millikelvin temperatures(13-16). Furthermore, we show that the unit cell can be operated at magnetic fields as low as 0.1 tesla, corresponding to a qubit control frequency of 3.5 gigahertz, where the qubit energy is well below the thermal energy. The unit cell constitutes the core building block of a full-scale silicon quantum computer and satisfies layout constraints required by error-correction architectures(8),(17). Our work indicates that a spin-based quantum computer could be operated at increased temperatures in a simple pumped He-4 system (which provides cooling power orders of magnitude higher than that of dilution refrigerators), thus potentially enabling the integration of classical control electronics with the qubit array(18,19).


  
The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity 期刊论文
ENVIRONMENTAL HEALTH PERSPECTIVES, 2019, 127 (4)
作者:  Li, Amy;  Lu, Xiaodong;  Natoli, Ted;  Bittker, Joshua;  Sipes, Nisha S.;  Subramanian, Aravind;  Auerbach, Scott;  Sherr, David H.;  Monti, Stefano
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/26
Improving air quality model predictions of organic species using measurement-derived organic gaseous and particle emissions in a petrochemical-dominated region 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (18) : 13531-13545
作者:  Stroud, Craig A.;  Makar, Paul A.;  Zhang, Junhua;  Moran, Michael D.;  Akingunola, Ayodeji;  Li, Shao-Meng;  Leithead, Amy;  Hayden, Katherine;  Siu, May
收藏  |  浏览/下载:15/0  |  提交时间:2019/04/09
Response to Comment on "Plant diversity increases with the strength of negative density dependence at the global scale" 期刊论文
SCIENCE, 2018, 360 (6391)
作者:  LaManna, Joseph A.;  Mangan, Scott A.;  Alonso, Alfonso;  Bourg, Norman A.;  Brockelman, Warren Y.;  Bunyavejchewin, Sarayudh;  Chang, Li-Wan;  Chiang, Jyh-Min;  Chuyong, George B.;  Clay, Keith;  Cordell, Susan;  Davies, Stuart J.;  Furniss, Tucker J.;  Giardina, Christian P.;  Gunatilleke, I. A. U. Nimal;  Gunatilleke, C. V. Savitri;  He, Fangliang;  Howe, Robert W.;  Hubbell, Stephen P.;  Hsieh, Chang-Fu;  Inman-Narahari, Faith M.;  Janik, David;  Johnson, Daniel J.;  Kenfack, David;  Korte, Lisa;  Kral, Kamil;  Larson, Andrew J.;  Lutz, James A.;  McMahon, Sean M.;  McShea, William J.;  Memiaghe, Herve R.;  Nathalang, Anuttara;  Novotny, Vojtech;  Ong, Perry S.;  Orwig, David A.;  Ostertag, Rebecca;  Parker, Geoffrey G.;  Phillips, Richard P.;  Sack, Lawren;  Sun, I-Fang;  Tello, J. Sebastian;  Thomas, Duncan W.;  Turner, Benjamin L.;  Diaz, Dilys M. Vela;  Vrska, Tomas;  Weiblen, George D.;  Wolf, Amy;  Yap, Sandra;  Myers, Jonathan A.
收藏  |  浏览/下载:54/0  |  提交时间:2019/11/27
Response to Comment on "Plant diversity increases with the strength of negative density dependence at the global scale" 期刊论文
SCIENCE, 2018, 360 (6391)
作者:  LaManna, Joseph A.;  Mangan, Scott A.;  Alonso, Alfonso;  Bourg, Norman A.;  Brockelman, Warren Y.;  Bunyavejchewin, Sarayudh;  Chang, Li-Wan;  Chiang, Jyh-Min;  Chuyong, George B.;  Clay, Keith;  Cordell, Susan;  Davies, Stuart J.;  Furniss, Tucker J.;  Giardina, Christian P.;  Gunatilleke, I. A. U. Nimal;  Gunatilleke, C. V. Savitri;  He, Fangliang;  Howe, Robert W.;  Hubbell, Stephen P.;  Hsieh, Chang-Fu;  Inman-Narahari, Faith M.;  Janik, David;  Johnson, Daniel J.;  Kenfack, David;  Korte, Lisa;  Kral, Kamil;  Larson, Andrew J.;  Lutz, James A.;  McMahon, Sean M.;  McShea, William J.;  Memiaghe, Herve R.;  Nathalang, Anuttara;  Novotny, Vojtech;  Ong, Perry S.;  Orwig, David A.;  Ostertag, Rebecca;  Parker, Geoffrey G.;  Phillips, Richard P.;  Sack, Lawren;  Sun, I-Fang;  Tello, J. Sebastian;  Thomas, Duncan W.;  Turner, Benjamin L.;  Diaz, Dilys M. Vela;  Vrska, Tomas;  Weiblen, George D.;  Wolf, Amy;  Yap, Sandra;  Myers, Jonathan A.
收藏  |  浏览/下载:47/0  |  提交时间:2019/11/27
Plant diversity increases with the strength of negative density dependence at the global scale 期刊论文
SCIENCE, 2017, 356 (6345) : 1389-1392
作者:  LaManna, Joseph A.;  Mangan, Scott A.;  Alonso, Alfonso;  Bourg, Norman A.;  Brockelman, Warren Y.;  Bunyavejchewin, Sarayudh;  Chang, Li-Wan;  Chiang, Jyh-Min;  Chuyong, George B.;  Clay, Keith;  Condit, Richard;  Cordell, Susan;  Davies, Stuart J.;  Furniss, Tucker J.;  Giardina, Christian P.;  Gunatilleke, I. A. U. Nimal;  Gunatilleke, C. V. Savitri;  He, Fangliang;  Howe, Robert W.;  Hubbell, Stephen P.;  Hsieh, Chang-Fu;  Inman-Narahari, Faith M.;  Janik, David;  Johnson, Daniel J.;  Kenfack, David;  Korte, Lisa;  Kral, Kamil;  Larson, Andrew J.;  Lutz, James A.;  McMahon, Sean M.;  McShea, William J.;  Memiaghe, Herve R.;  Nathalang, Anuttara;  Novotny, Vojtech;  Ong, Perry S.;  Orwig, David A.;  Ostertag, Rebecca;  Parker, Geoffrey G.;  Phillips, Richard P.;  Sack, Lawren;  Sun, I-Fang;  Tello, J. Sebastian;  Thomas, Duncan W.;  Turner, Benjamin L.;  Diaz, Dilys M. Vela;  Vrska, Tomas;  Weiblen, George D.;  Wolf, Amy;  Yap, Sandra;  Myers, Jonathan A.
收藏  |  浏览/下载:29/0  |  提交时间:2019/11/27