GSTDTAP

浏览/检索结果: 共6条,第1-6条 帮助

已选(0)清除 条数/页:   排序方式:
Haplotype-resolved diverse human genomes and integrated analysis of structural variation 期刊论文
Science, 2021
作者:  Peter Ebert;  Peter A. Audano;  Qihui Zhu;  Bernardo Rodriguez-Martin;  David Porubsky;  Marc Jan Bonder;  Arvis Sulovari;  Jana Ebler;  Weichen Zhou;  Rebecca Serra Mari;  Feyza Yilmaz;  Xuefang Zhao;  PingHsun Hsieh;  Joyce Lee;  Sushant Kumar;  Jiadong Lin;  Tobias Rausch;  Yu Chen;  Jingwen Ren;  Martin Santamarina;  Wolfram Höps;  Hufsah Ashraf;  Nelson T. Chuang;  Xiaofei Yang;  Katherine M. Munson;  Alexandra P. Lewis;  Susan Fairley;  Luke J. Tallon;  Wayne E. Clarke;  Anna O. Basile;  Marta Byrska-Bishop;  André Corvelo;  Uday S. Evani;  Tsung-Yu Lu;  Mark J. P. Chaisson;  Junjie Chen;  Chong Li;  Harrison Brand;  Aaron M. Wenger;  Maryam Ghareghani;  William T. Harvey;  Benjamin Raeder;  Patrick Hasenfeld;  Allison A. Regier;  Haley J. Abel;  Ira M. Hall;  Paul Flicek;  Oliver Stegle;  Mark B. Gerstein;  Jose M. C. Tubio;  Zepeng Mu;  Yang I. Li;  Xinghua Shi;  Alex R. Hastie;  Kai Ye;  Zechen Chong;  Ashley D. Sanders;  Michael C. Zody;  Michael E. Talkowski;  Ryan E. Mills;  Scott E. Devine;  Charles Lee;  Jan O. Korbel;  Tobias Marschall;  Evan E. Eichler
收藏  |  浏览/下载:26/0  |  提交时间:2021/04/06
Intraplate volcanism originating from upwelling hydrous mantle transition zone 期刊论文
NATURE, 2020
作者:  Calabrese, Claudia;  Davidson, Natalie R.;  Demircioglu, Deniz;  Fonseca, Nuno A.;  He, Yao;  Kahles, Andre;  Kjong-Van Lehmann;  Liu, Fenglin;  Shiraishi, Yuichi;  Soulette, Cameron M.;  Urban, Lara;  Greger, Liliana;  Li, Siliang;  Liu, Dongbing;  Perry, Marc D.;  Xiang, Qian;  Zhang, Fan;  Zhang, Junjun;  Bailey, Peter;  Erkek, Serap;  Hoadley, Katherine A.;  Hou, Yong;  Huska, Matthew R.;  Kilpinen, Helena;  Korbel, Jan O.;  Marin, Maximillian G.;  Markowski, Julia;  Nandi, Tannistha;  Pan-Hammarstrom, Qiang;  Pedamallu, Chandra Sekhar;  Siebert, Reiner;  Stark, Stefan G.;  Su, Hong;  Tan, Patrick;  Waszak, Sebastian M.;  Yung, Christina;  Zhu, Shida;  Awadalla, Philip;  Creighton, Chad J.;  Meyerson, Matthew;  Ouellette, B. F. Francis;  Wu, Kui;  Yang, Huanming;  Brazma, Alvis;  Brooks, Angela N.;  Goke, Jonathan;  Raetsch, Gunnar;  Schwarz, Roland F.;  Stegle, Oliver;  Zhang, Zemin
收藏  |  浏览/下载:75/0  |  提交时间:2020/05/13

Most magmatism occurring on Earth is conventionally attributed to passive mantle upwelling at mid-ocean ridges, to slab devolatilization at subduction zones, or to mantle plumes. However, the widespread Cenozoic intraplate volcanism in northeast China(1-3) and the young petit-spot volcanoes(4-7) offshore of the Japan Trench cannot readily be associated with any of these mechanisms. In addition, the mantle beneath these types of volcanism is characterized by zones of anomalously low seismic velocity above and below the transition zone(8-12) (a mantle level located at depths between 410 and 660 kilometres). A comprehensive interpretation of these phenomena is lacking. Here we show that most (or possibly all) of the intraplate and petit-spot volcanism and low-velocity zones around the Japanese subduction zone can be explained by the Cenozoic interaction of the subducting Pacific slab with a hydrous mantle transition zone. Numerical modelling indicates that 0.2 to 0.3 weight per cent of water dissolved in mantle minerals that are driven out from the transition zone in response to subduction and retreat of a tectonic plate is sufficient to reproduce the observations. This suggests that a critical amount of water may have accumulated in the transition zone around this subduction zone, as well as in others of the Tethyan tectonic belt(13) that are characterized by intraplate or petit-spot volcanism and low-velocity zones in the underlying mantle.


The widespread intraplate volcanism in northeast China and the unusual '  petit-spot'  volcanoes offshore Japan could have resulted from the interaction of the subducting Pacific slab with a hydrous mantle transition zone.


  
The germline genetic component of drug sensitivity in cancer cell lines 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Menden, Michael P.;  Casale, Francesco Paolo;  Stephan, Johannes;  Bignell, Graham R.;  Iorio, Francesco;  McDermott, Ultan;  Garnett, Mathew J.;  Saez-Rodriguez, Julio;  Stegle, Oliver
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Single-cell epigenomics: Recording the past and predicting the future 期刊论文
SCIENCE, 2017, 358 (6359) : 69-75
作者:  Kelsey, Gavin;  Stegle, Oliver;  Reik, Wolf
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Common genetic variation drives molecular heterogeneity in human iPSCs 期刊论文
NATURE, 2017, 546 (7658) : 370-+
作者:  Kilpinen, Helena;  Goncalves, Angela;  Leha, Andreas;  Afzal, Vackar;  Alasoo, Kaur;  Ashford, Sofie;  Bala, Sendu;  Bensaddek, Dalila;  Casale, Francesco Paolo;  Ulley, Oliver J. C.;  Danecek, Petr;  Faulconbridge, Adam;  Harrison, Peter W.;  Kathuria, Annie;  McCarthy, Davis;  McCarthy, Shane A.;  Meleckyte, Ruta;  Memari, Yasin;  Moens, Nathalie;  Soares, Filipa;  Mann, Alice;  Streeter, Ian;  Agu, Chukwuma A.;  Alderton, Alex;  Nelson, Rachel;  Harper, Sarah;  Patel, Minal;  White, Alistair;  Patel, Sharad R.;  Clarke, Laura;  Halai, Reena;  Kirton, Christopher M.;  Kolb-Kokocinski, Anja;  Beales, Philip;  Birney, Ewan;  Danovi, Davide;  Lamond, Angus I.;  Ouwehand, Willem H.;  Vallier, Ludovic;  Watt, Fiona M.;  Durbin, Richard;  Stegle, Oliver;  Gaffney, Daniel J.
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Genetic variants regulating expression levels and isoform diversity during embryogenesis 期刊论文
NATURE, 2017, 541 (7637) : 402-+
作者:  Cannavo, Enrico;  Koelling, Nils;  Harnett, Dermot;  Garfield, David;  Casale, Francesco P.;  Ciglar, Lucia;  Gustafson, Hilary E.;  Viales, Rebecca R.;  Marco-Ferreres, Raquel;  Degner, Jacob F.;  Zhao, Bingqing;  Stegle, Oliver;  Birney, Ewan;  Furlong, Eileen E. M.
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09