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Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline (vol 566, pg 105, 2019) 期刊论文
NATURE, 2020, 577 (7792) : E8-E8
作者:  Grunwald, Hannah A.;  Gantz, Valentino M.;  Poplawski, Gunnar;  Xu, Xiang-Ru S.;  Bier, Ethan;  Cooper, Kimberly L.
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

An Amendment to this paper has been published and can be accessed via a link at the top of the paper.


  
A cold, massive, rotating disk galaxy 1.5 billion years after the Big Bang 期刊论文
NATURE, 2020, 581 (7808) : 269-+
作者:  Poplawski, Gunnar H. D.;  Kawaguchi, Riki;  Van Niekerk, Erna;  Lu, Paul;  Mehta, Neil;  Canete, Philip;  Lie, Richard;  Dragatsis, Ioannis;  Meves, Jessica M.;  Zheng, Binhai;  Coppola, Giovanni;  Tuszynski, Mark H.
收藏  |  浏览/下载:83/0  |  提交时间:2020/07/03

Massive disk galaxies like the Milky Way are expected to form at late times in traditional models of galaxy formation(1,2), but recent numerical simulations suggest that such galaxies could form as early as a billion years after the Big Bang through the accretion of cold material and mergers(3,4). Observationally, it has been difficult to identify disk galaxies in emission at high redshift(5,6) in order to discern between competing models of galaxy formation. Here we report imaging, with a resolution of about 1.3 kiloparsecs, of the 158-micrometre emission line from singly ionized carbon, the far-infrared dust continuum and the near-ultraviolet continuum emission from a galaxy at a redshift of 4.2603, identified by detecting its absorption of quasar light. These observations show that the emission arises from gas inside a cold, dusty, rotating disk with a rotational velocity of about 272 kilometres per second. The detection of emission from carbon monoxide in the galaxy yields a molecular mass that is consistent with the estimate from the ionized carbon emission of about 72 billion solar masses. The existence of such a massive, rotationally supported, cold disk galaxy when the Universe was only 1.5 billion years old favours formation through either cold-mode accretion or mergers, although its large rotational velocity and large content of cold gas remain challenging to reproduce with most numerical simulations(7,8).


A massive rotating disk galaxy was formed a mere 1.5 billion years after the Big Bang, a surprisingly short time after the origin of the Universe.


  
Ancient West African foragers in the context of African population history 期刊论文
NATURE, 2020, 577 (7792) : 665-+
作者:  Grunwald, Hannah A.;  Gantz, Valentino M.;  Poplawski, Gunnar;  Xu, Xiang-Ru S.;  Bier, Ethan;  Cooper, Kimberly L.
收藏  |  浏览/下载:44/0  |  提交时间:2020/07/03

Genome-wide ancestry profiles of four individuals, dating to 8,000 and 3,000 years before present, from the archaeological site of Shum Laka (Cameroon) shed light on the deep population history of sub-Saharan Africa.


Our knowledge of ancient human population structure in sub-Saharan Africa, particularly prior to the advent of food production, remains limited. Here we report genome-wide DNA data from four children-two of whom were buried approximately 8,000 years ago and two 3,000 years ago-from Shum Laka (Cameroon), one of the earliest known archaeological sites within the probable homeland of the Bantu language group(1-11). One individual carried the deeply divergent Y chromosome haplogroup A00, which today is found almost exclusively in the same region(12,13). However, the genome-wide ancestry profiles of all four individuals are most similar to those of present-day hunter-gatherers from western Central Africa, which implies that populations in western Cameroon today-as well as speakers of Bantu languages from across the continent-are not descended substantially from the population represented by these four people. We infer an Africa-wide phylogeny that features widespread admixture and three prominent radiations, including one that gave rise to at least four major lineages deep in the history of modern humans.