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Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women 期刊论文
Science, 2021
作者:  Mihoko Yoshino;  Jun Yoshino;  Brandon D. Kayser;  Gary J. Patti;  Michael P. Franczyk;  Kathryn F. Mills;  Miriam Sindelar;  Terri Pietka;  Bruce W. Patterson;  Shin-Ichiro Imai;  Samuel Klein
收藏  |  浏览/下载:36/0  |  提交时间:2021/06/15
Environmental variability supports chimpanzee behavioural diversity 期刊论文
Nature Communications, 2020
作者:  Ammie K. Kalan;  Lars Kulik;  Mimi Arandjelovic;  Christophe Boesch;  Fabian Haas;  Paula Dieguez;  Christopher D. Barratt;  Ekwoge E. Abwe;  Anthony Agbor;  Samuel Angedakin;  Floris Aubert;  Emmanuel Ayuk Ayimisin;  Emma Bailey;  Mattia Bessone;  Gregory Brazzola;  Valentine Ebua Buh;  Rebecca Chancellor;  Heather Cohen;  Charlotte Coupland;  Bryan Curran;  Emmanuel Danquah;  Tobias Deschner;  Dervla Dowd;  Manasseh Eno-Nku;  J. Michael Fay;  Annemarie Goedmakers;  Anne-Cé;  line Granjon;  Josephine Head;  Daniela Hedwig;  Veerle Hermans;  Kathryn J. Jeffery;  Sorrel Jones;  Jessica Junker;  Parag Kadam;  Mohamed Kambi;  Ivonne Kienast;  Deo Kujirakwinja;  Kevin E. Langergraber;  Juan Lapuente;  Bradley Larson;  Kevin C. Lee;  Vera Leinert;  Manuel Llana;  Sergio Marrocoli;  Amelia C. Meier;  Bethan Morgan;  David Morgan;  Emily Neil;  Sonia Nicholl;  Emmanuelle Normand;  Lucy Jayne Ormsby;  Liliana Pacheco;  Alex Piel;  Jodie Preece;  Martha M. Robbins;  Aaron Rundus;  Crickette Sanz;  Volker Sommer;  Fiona Stewart;  Nikki Tagg;  Claudio Tennie;  Virginie Vergnes;  Adam Welsh;  Erin G. Wessling;  Jacob Willie;  Roman M. Wittig;  Yisa Ginath Yuh;  Klaus Zuberbü;  hler;  Hjalmar S. Kü;  hl
收藏  |  浏览/下载:47/0  |  提交时间:2020/09/22
A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
收藏  |  浏览/下载:89/0  |  提交时间:2020/07/06

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.


  
Sediment routing from shelf to basin floor in the Quaternary Golo System of Eastern Corsica, France, western Mediterranean Sea 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (5-6) : 1217-1234
作者:  Sweet, Michael L.;  Gaillot, Gwladys T.;  Jouet, Gwenael;  Rittenour, Tammy M.;  Toucanne, Samuel;  Marsset, Tania;  Blum, Michael D.
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/02
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline 期刊论文
NATURE, 2020, 581 (7806) : 70-+
作者:  Doherty, Tiarnan A. S.;  Winchester, Andrew J.;  Macpherson, Stuart;  Johnstone, Duncan N.;  Pareek, Vivek;  Tennyson, Elizabeth M.;  Kosar, Sofiia;  Kosasih, Felix U.;  Anaya, Miguel;  Abdi-Jalebi, Mojtaba;  Andaji-Garmaroudi, Zahra;  Wong, E. Laine;  Madeo, Julien;  Chiang, Yu-Hsien;  Park, Ji-Sang;  Jung, Young-Kwang;  Petoukhoff, Christopher E.;  Divitini, Giorgio;  Man, Michael K. L.;  Ducati, Caterina;  Walsh, Aron;  Midgley, Paul A.;  Dani, Keshav M.;  Stranks, Samuel D.
收藏  |  浏览/下载:57/0  |  提交时间:2020/07/03

Breakdown of the blood-brain barrier in individuals carrying the epsilon 4 allele of the APOE gene, but not the epsilon 3 allele, increases with and predicts cognitive impairment and is independent of amyloid beta or tau pathology.


Vascular contributions to dementia and Alzheimer'  s disease are increasingly recognized(1-6). Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction(7), including the early clinical stages of Alzheimer'  s disease(5,8-10). The E4 variant of apolipoprotein E (APOE4), the main susceptibility gene for Alzheimer'  s disease(11-14), leads to accelerated breakdown of the BBB and degeneration of brain capillary pericytes(15-19), which maintain BBB integrity(20-22). It is unclear, however, whether the cerebrovascular effects of APOE4 contribute to cognitive impairment. Here we show that individuals bearing APOE4 (with the epsilon 3/epsilon 4 or epsilon 4/epsilon 4 alleles) are distinguished from those without APOE4 (epsilon 3/epsilon 3) by breakdown of the BBB in the hippocampus and medial temporal lobe. This finding is apparent in cognitively unimpaired APOE4 carriers and more severe in those with cognitive impairment, but is not related to amyloid-beta or tau pathology measured in cerebrospinal fluid or by positron emission tomography(23). High baseline levels of the BBB pericyte injury biomarker soluble PDGFR beta(7,8) in the cerebrospinal fluid predicted future cognitive decline in APOE4 carriers but not in non-carriers, even after controlling for amyloid-beta and tau status, and were correlated with increased activity of the BBB-degrading cyclophilin A-matrix metalloproteinase-9 pathway(19) in cerebrospinal fluid. Our findings suggest that breakdown of the BBB contributes to APOE4-associated cognitive decline independently of Alzheimer'  s disease pathology, and might be a therapeutic target in APOE4 carriers.


  
Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Kahn, Suzana A.;  Wang, Xin;  Nitta, Ryan T.;  Gholamin, Sharareh;  Theruvath, Johanna;  Hutter, Gregor;  Azad, Tej D.;  Wadi, Lina;  Bolin, Sara;  Ramaswamy, Vijay;  Esparza, Rogelio;  Liu, Kun-Wei;  Edwards, Michael;  Swartling, Fredrik J.;  Sahoo, Debashis;  Li, Gordon;  Wechsler-Reya, Robert J.;  Reimand, Juri;  Cho, Yoon-Jae;  Taylor, Michael D.;  Weissman, Irving L.;  Mitra, Siddhartha S.;  Cheshier, Samuel H.
收藏  |  浏览/下载:29/0  |  提交时间:2019/11/27
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate 期刊论文
SCIENCE, 2019, 363 (6432) : 1217-+
作者:  Chakraborty, Abhishek A.;  Laukka, Tuomas;  Myllykoski, Matti;  Ringel, Alison E.;  Booker, Matthew A.;  Tolstorukov, Michael Y.;  Meng, Yuzhong Jeff;  Meier, Samuel R.;  Jennings, Rebecca B.;  Creech, Amanda L.;  Herbert, Zachary T.;  McBrayer, Samuel K.;  Olenchock, Benjamin A.;  Jaffe, Jacob D.;  Haigis, Marcia C.;  Beroukhim, Rameen;  Signoretti, Sabina;  Koivunen, Peppi;  Kaelin, William G., Jr.
收藏  |  浏览/下载:21/0  |  提交时间:2019/11/27
Cloud impacts on photochemistry: building a climatology of photolysis rates from the Atmospheric Tomography mission 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (22) : 16809-16828
作者:  Hall, Samuel R.;  Ullmann, Kirk;  Prather, Michael J.;  Flynn, Clare M.;  Murray, Lee T.;  Fiore, Arlene M.;  Correa, Gustavo;  Strode, Sarah A.;  Steenrod, Stephen D.;  Lamarque, Jean-Francois;  Guth, Jonathan;  Josse, Beatrice;  Flemming, Johannes;  Huijnen, Vincent;  Abraham, N. Luke;  Archibald, Alex T.
收藏  |  浏览/下载:22/0  |  提交时间:2019/04/09
Palaeoclimate constraints on the impact of 2 degrees C anthropogenic warming and beyond (vol 11, pg 474, 2018) 期刊论文
NATURE GEOSCIENCE, 2018, 11 (8) : 615-615
作者:  Fischer, Hubertus;  Meissner, Katrin J.;  Mix, Alan C.;  Abram, Nerilie J.;  Austermann, Jacqueline;  Brovkin, Victor;  Capron, Emilie;  Colombaroli, Daniele;  Daniau, Anne-Laure;  Dyez, Kelsey A.;  Felis, Thomas;  Finkelstein, Sarah A.;  Jaccard, Samuel L.;  McClymont, Erin L.;  Rovere, Alessio;  Sutter, Johannes;  Wolff, Eric W.;  Affolter, Stephane;  Bakker, Pepijn;  Ballesteros-Canovas, Juan Antonio;  Barbante, Carlo;  Caley, Thibaut;  Carlson, Anders E.;  Churakova (Sidorova), Olga;  Cortese, Giuseppe;  Cumming, Brian F.;  Davis, Basil A. S.;  de Vernal, Anne;  Emile-Geay, Julien;  Fritz, Sherilyn C.;  Gierz, Paul;  Gottschalk, Julia;  Holloway, Max D.;  Joos, Fortunat;  Kucera, Michal;  Loutre, Marie-France;  Lunt, Daniel J.;  Marcisz, Katarzyna;  Marlon, Jennifer R.;  Martinez, Philippe;  Masson-Delmotte, Valerie;  Nehrbass-Ahles, Christoph;  Otto-Bliesner, Bette L.;  Raible, Christoph C.;  Risebrobakken, Bjorg;  Goni, Maria F. Sanchez;  Arrigo, Jennifer Saleem;  Sarnthein, Michael;  Sjolte, Jesper;  Stocker, Thomas F.;  Alvarez, Patricio A. Velasquez;  Tinner, Willy;  Valdes, Paul J.;  Vogel, Hendrik;  Wanner, Heinz;  Yan, Qing;  Yu, Zicheng;  Ziegler, Martin;  Zhou, Liping
收藏  |  浏览/下载:37/0  |  提交时间:2019/04/09
Palaeoclimate constraints on the impact of 2 degrees C anthropogenic warming and beyond 期刊论文
NATURE GEOSCIENCE, 2018, 11 (7) : 474-485
作者:  Fischer, Hubertus;  Meissner, Katrin J.;  Mix, Alan C.;  Abram, Nerilie J.;  Austermann, Jacqueline;  Brovkin, Victor;  Capron, Emilie;  Colombaroli, Daniele;  Daniau, Anne-Laure;  Dyez, Kelsey A.;  Felis, Thomas;  Finkelstein, Sarah A.;  Jaccard, Samuel L.;  McClymont, Erin L.;  Rovere, Alessio;  Sutter, Johannes;  Wolff, Eric W.;  Affolter, Stephane;  Bakker, Pepijn;  Ballesteros-Canovas, Juan Antonio;  Barbante, Carlo;  Caley, Thibaut;  Carlson, Anders E.;  Churakova (Sidorova), Olga;  Cortese, Giuseppe;  Cumming, Brian F.;  Davis, Basil A. S.;  de Vernal, Anne;  Emile-Geay, Julien;  Fritz, Sherilyn C.;  Gierz, Paul;  Gottschalk, Julia;  Holloway, Max D.;  Joos, Fortunat;  Kucera, Michal;  Loutre, Marie-France;  Lunt, Daniel J.;  Marcisz, Katarzyna;  Marlon, Jennifer R.;  Martinez, Philippe;  Masson-Delmotte, Valerie;  Nehrbass-Ahles, Christoph;  Otto-Bliesner, Bette L.;  Raible, Christoph C.;  Risebrobakken, Bjorg;  Goni, Maria F. Sanchez;  Arrigo, Jennifer Saleem;  Sarnthein, Michael;  Sjolte, Jesper;  Stocker, Thomas F.;  Alvarez, Patricio A. Velasquez;  Tinner, Willy;  Valdes, Paul J.;  Vogel, Hendrik;  Wanner, Heinz;  Yan, Qing;  Yu, Zicheng;  Ziegler, Martin;  Zhou, Liping
收藏  |  浏览/下载:39/0  |  提交时间:2019/04/09