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Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants 期刊论文
Science, 2021
作者:  Lingshu Wang;  Tongqing Zhou;  Yi Zhang;  Eun Sung Yang;  Chaim A. Schramm;  Wei Shi;  Amarendra Pegu;  Olamide K. Oloniniyi;  Amy R. Henry;  Samuel Darko;  Sandeep R. Narpala;  Christian Hatcher;  David R. Martinez;  Yaroslav Tsybovsky;  Emily Phung;  Olubukola M. Abiona;  Avan Antia;  Evan M. Cale;  Lauren A. Chang;  Misook Choe;  Kizzmekia S. Corbett;  Rachel L. Davis;  Anthony T. DiPiazza;  Ingelise J. Gordon;  Sabrina Helmold Hait;  Tandile Hermanus;  Prudence Kgagudi;  Farida Laboune;  Kwanyee Leung;  Tracy Liu;  Rosemarie D. Mason;  Alexandra F. Nazzari;  Laura Novik;  Sarah O’Connell;  Sijy O’Dell;  Adam S. Olia;  Stephen D. Schmidt;  Tyler Stephens;  Christopher D. Stringham;  Chloe Adrienna Talana;  I-Ting Teng;  Danielle A. Wagner;  Alicia T. Widge;  Baoshan Zhang;  Mario Roederer;  Julie E. Ledgerwood;  Tracy J. Ruckwardt;  Martin R. Gaudinski;  Penny L. Moore;  Nicole A. Doria-Rose;  Ralph S. Baric;  Barney S. Graham;  Adrian B. McDermott;  Daniel C. Douek;  Peter D. Kwong;  John R. Mascola;  Nancy J. Sullivan;  John Misasi
收藏  |  浏览/下载:21/0  |  提交时间:2021/08/17
Insights from Earth system model initial-condition large ensembles and future prospects (vol 89, pg 516, 2020) 期刊论文
NATURE CLIMATE CHANGE, 2020
作者:  Deser, C.;  Lehner, F.;  Rodgers, K. B.;  Ault, T.;  Delworth, T. L.;  DiNezio, P. N.;  Fiore, A.;  Frankignoul, C.;  Fyfe, J. C.;  Horton, D. E.;  Kay, J. E.;  Knutti, R.;  Lovenduski, N. S.;  Marotzke, J.;  McKinnon, K. A.;  Minobe, S.;  Randerson, J.;  Screen, J. A.;  Simpson, I. R.;  Ting, M.
收藏  |  浏览/下载:9/0  |  提交时间:2020/06/29
Single-chain heteropolymers transport protons selectively and rapidly 期刊论文
NATURE, 2020, 577 (7789) : 216-+
作者:  Jiang, Tao;  Hall, Aaron;  Eres, Marco;  Hemmatian, Zahra;  Qiao, Baofu;  Zhou, Yun;  Ruan, Zhiyuan;  Couse, Andrew D.;  Heller, William T.;  Huang, Haiyan;  de la Cruz, Monica Olvera;  Rolandi, Marco;  Xu, Ting
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/03

Precise protein sequencing and folding are believed to generate the structure and chemical diversity of natural channels(1,2), both of which are essential to synthetically achieve proton transport performance comparable to that seen in natural systems. Geometrically defined channels have been fabricated using peptides, DNAs, carbon nanotubes, sequence-defined polymers and organic frameworks(3-13). However, none of these channels rivals the performance observed in their natural counterparts. Here we show that without forming an atomically structured channel, four-monomer-based random heteropolymers (RHPs)(14) can mimic membrane proteins and exhibit selective proton transport across lipid bilayers at a rate similar to those of natural proton channels. Statistical control over the monomer distribution in an RHP leads to segmental heterogeneity in hydrophobicity, which facilitates the insertion of single RHPs into the lipid bilayers. It also results in bilayer-spanning segments containing polar monomers that promote the formation of hydrogen-bonded chains(15,16) for proton transport. Our study demonstrates the importance of the adaptability that is enabled by statistical similarity among RHP chains and of the modularity provided by the chemical diversity of monomers, to achieve uniform behaviour in heterogeneous systems. Our results also validate statistical randomness as an unexplored approach to realize protein-like behaviour at the single-polymer-chain level in a predictable manner.


  
Insights from Earth system model initial-condition large ensembles and future prospects 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (4) : 277-+
作者:  Deser, C.;  Lehner, F.;  Rodgers, K. B.;  Ault, T.;  Delworth, T. L.;  DiNezio, P. N.;  Fiore, A.;  Frankignoul, C.;  Fyfe, J. C.;  Horton, D. E.;  Kay, J. E.;  Knutti, R.;  Lovenduski, N. S.;  Marotzke, J.;  McKinnon, K. A.;  Minobe, S.;  Randerson, J.;  Screen, J. A.;  Simpson, I. R.;  Ting, M.
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13
Highly porous nature of a primitive asteroid revealed by thermal imaging 期刊论文
NATURE, 2020, 579 (7800) : 518-522
作者:  Quinn, Robert A.;  Melnik, Alexey, V;  Vrbanac, Alison;  Fu, Ting;  Patras, Kathryn A.;  Christy, Mitchell P.;  Bodai, Zsolt;  Belda-Ferre, Pedro;  Tripathi, Anupriya;  Chung, Lawton K.;  Downes, Michael;  Welch, Ryan D.;  Quinn, Melissa;  Humphrey, Greg;  Panitchpakdi, Morgan;  Weldon, Kelly C.;  Aksenov, Alexander;  da Silva, Ricardo;  Avila-Pacheco, Julian;  Clish, Clary;  Bae, Sena;  Mallick, Himel;  Franzosa, Eric A.;  Lloyd-Price, Jason;  Bussell, Robert;  Thron, Taren;  Nelson, Andrew T.;  Wang, Mingxun;  Leszczynski, Eric;  Vargas, Fernando;  Gauglitz, Julia M.;  Meehan, Michael J.;  Gentry, Emily;  Arthur, Timothy D.;  Komor, Alexis C.;  Poulsen, Orit;  Boland, Brigid S.;  Chang, John T.;  Sandborn, William J.;  Lim, Meerana;  Garg, Neha;  Lumeng, Julie C.;  Xavier, Ramnik J.;  Kazmierczak, Barbara, I;  Jain, Ruchi;  Egan, Marie;  Rhee, Kyung E.;  Ferguson, David;  Raffatellu, Manuela;  Vlamakis, Hera;  Haddad, Gabriel G.;  Siegel, Dionicio;  Huttenhower, Curtis;  Mazmanian, Sarkis K.;  Evans, Ronald M.;  Nizet, Victor;  Knight, Rob;  Dorrestein, Pieter C.
收藏  |  浏览/下载:50/0  |  提交时间:2020/05/13

Carbonaceous (C-type) asteroids(1) are relics of the early Solar System that have preserved primitive materials since their formation approximately 4.6 billion years ago. They are probably analogues of carbonaceous chondrites(2,3) and are essential for understanding planetary formation processes. However, their physical properties remain poorly known because carbonaceous chondrite meteoroids tend not to survive entry to Earth'  s atmosphere. Here we report on global one-rotation thermographic images of the C-type asteroid 162173 Ryugu, taken by the thermal infrared imager (TIR)(4) onboard the spacecraft Hayabusa2(5), indicating that the asteroid'  s boulders and their surroundings have similar temperatures, with a derived thermal inertia of about 300 J m(-2) s(-0.5) K-1 (300 tiu). Contrary to predictions that the surface consists of regolith and dense boulders, this low thermal inertia suggests that the boulders are more porous than typical carbonaceous chondrites(6) and that their surroundings are covered with porous fragments more than 10 centimetres in diameter. Close-up thermal images confirm the presence of such porous fragments and the flat diurnal temperature profiles suggest a strong surface roughness effect(7,8). We also observed in the close-up thermal images boulders that are colder during the day, with thermal inertia exceeding 600 tiu, corresponding to dense boulders similar to typical carbonaceous chondrites(6). These results constrain the formation history of Ryugu: the asteroid must be a rubble pile formed from impact fragments of a parent body with microporosity(9) of approximately 30 to 50 per cent that experienced a low degree of consolidation. The dense boulders might have originated from the consolidated innermost region or they may have an exogenic origin. This high-porosity asteroid may link cosmic fluffy dust to dense celestial bodies(10).


Thermal imaging data obtained from the spacecraft Hayabusa2 reveal that the carbonaceous asteroid 162173 Ryugu is an object of unusually high porosity.


  
Experimental demonstration of memory-enhanced quantum communication 期刊论文
NATURE, 2020
作者:  Quinn, Robert A.;  Melnik, Alexey, V;  Vrbanac, Alison;  Fu, Ting;  Patras, Kathryn A.;  Christy, Mitchell P.;  Bodai, Zsolt;  Belda-Ferre, Pedro;  Tripathi, Anupriya;  Chung, Lawton K.;  Downes, Michael;  Welch, Ryan D.;  Quinn, Melissa;  Humphrey, Greg;  Panitchpakdi, Morgan;  Weldon, Kelly C.;  Aksenov, Alexander;  da Silva, Ricardo;  Avila-Pacheco, Julian;  Clish, Clary;  Bae, Sena;  Mallick, Himel;  Franzosa, Eric A.;  Lloyd-Price, Jason;  Bussell, Robert;  Thron, Taren;  Nelson, Andrew T.;  Wang, Mingxun;  Leszczynski, Eric;  Vargas, Fernando;  Gauglitz, Julia M.;  Meehan, Michael J.;  Gentry, Emily;  Arthur, Timothy D.;  Komor, Alexis C.;  Poulsen, Orit;  Boland, Brigid S.;  Chang, John T.;  Sandborn, William J.;  Lim, Meerana;  Garg, Neha;  Lumeng, Julie C.;  Xavier, Ramnik J.;  Kazmierczak, Barbara, I;  Jain, Ruchi;  Egan, Marie;  Rhee, Kyung E.;  Ferguson, David;  Raffatellu, Manuela;  Vlamakis, Hera;  Haddad, Gabriel G.;  Siegel, Dionicio;  Huttenhower, Curtis;  Mazmanian, Sarkis K.;  Evans, Ronald M.;  Nizet, Victor;  Knight, Rob;  Dorrestein, Pieter C.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

The ability to communicate quantum information over long distances is of central importance in quantum science and engineering(1). Although some applications of quantum communication such as secure quantum key distribution(2,3) are already being successfully deployed(4-7), their range is currently limited by photon losses and cannot be extended using straightforward measure-and-repeat strategies without compromising unconditional security(8). Alternatively, quantum repeaters(9), which utilize intermediate quantum memory nodes and error correction techniques, can extend the range of quantum channels. However, their implementation remains an outstanding challenge(10-16), requiring a combination of efficient and high-fidelity quantum memories, gate operations, and measurements. Here we use a single solid-state spin memory integrated in a nanophotonic diamond resonator(17-19) to implement asynchronous photonic Bell-state measurements, which are a key component of quantum repeaters. In a proof-of-principle experiment, we demonstrate high-fidelity operation that effectively enables quantum communication at a rate that surpasses the ideal loss-equivalent direct-transmission method while operating at megahertz clock speeds. These results represent a crucial step towards practical quantum repeaters and large-scale quantum networks(20,21).


A solid-state spin memory is used to demonstrate quantum repeater functionality, which has the potential to overcome photon losses involved in long-distance transmission of quantum information.


  
Streamflow response to forest management 期刊论文
NATURE, 2020, 578 (7794) : E12-E15
作者:  Jiang, Tao;  Hall, Aaron;  Eres, Marco;  Hemmatian, Zahra;  Qiao, Baofu;  Zhou, Yun;  Ruan, Zhiyuan;  Couse, Andrew D.;  Heller, William T.;  Huang, Haiyan;  de la Cruz, Monica Olvera;  Rolandi, Marco;  Xu, Ting
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/13
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition (vol 363, eaaw7579, 2019) 期刊论文
SCIENCE, 2019, 363 (6425)
作者:  Yu, M.;  Bardia, A.;  Wittner, B. S.;  Stott, S. L.;  Smas, M. E.;  Ting, D. T.;  Isakoff, S. J.;  Ciciliano, J. C.;  Wells, M. N.;  Shah, A. M.;  Concannon, K. F.;  Donaldson, M. C.;  Sequist, L. V.;  Brachtel, E.;  Sgroi, D.;  Baselga, J.;  Ramaswamy, S.;  Toner, M.;  Haber, D. A.;  Maheswaran, S.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Black-carbon absorption enhancement in the atmosphere determined by particle mixing state 期刊论文
NATURE GEOSCIENCE, 2017, 10 (3)
作者:  Liu, Dantong;  Whitehead, James;  Alfarra, M. Rami;  Reyes-Villegas, Ernesto;  Spracklen, Dominick V.;  Reddington, Carly L.;  Kong, Shaofei;  Williams, Paul I.;  Ting, Yu-Chieh;  Haslett, Sophie;  Taylor, Jonathan W.;  Flynn, Michael J.;  Morgan, William T.;  McFiggans, Gordon;  Coe, Hugh;  Allan, James D.
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09