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Global maps of soil temperature 期刊论文
Global Change Biology, 2022
作者:  Jonas J. Lembrechts;  Johan van den Hoogen;  Juha Aalto;  Michael B. Ashcroft;  Pieter De Frenne;  Julia Kemppinen;  Martin Kopecký;  Miska Luoto;  Ilya M. D. Maclean;  Thomas W. Crowther;  Joseph J. Bailey;  Stef Haesen;  David H. Klinges;  Pekka Niittynen;  Brett R. Scheffers;  Koenraad Van Meerbeek;  Peter Aartsma;  Otar Abdalaze;  Mehdi Abedi;  Rien Aerts;  Negar Ahmadian;  Antje Ahrends;  Juha M. Alatalo;  Jake M. Alexander;  Camille Nina Allonsius;  Jan Altman;  Christof Ammann;  Christian Andres;  Christopher Andrews;  Jonas Ardö;  Nicola Arriga;  Alberto Arzac;  Valeria Aschero;  Rafael L. Assis;  Jakob Johann Assmann;  Maaike Y. Bader;  Khadijeh Bahalkeh;  Peter Baranč;  ok;  Isabel C. Barrio;  Agustina Barros;  Matti Barthel;  Edmund W. Basham;  Marijn Bauters;  Manuele Bazzichetto;  Luca Belelli Marchesini;  Michael C. Bell;  Juan C. Benavides;  José;  Luis Benito Alonso;  Bernd J. Berauer;  Jarle W. Bjerke;  Robert G. Bjö;  rk;  Mats P. Bjö;  rkman;  Katrin Bjö;  rnsdó;  ttir;  Benjamin Blonder;  Pascal Boeckx;  Julia Boike;  Stef Bokhorst;  ;  rbara N. S. Brum;  Josef Brů;  na;  Nina Buchmann;  Pauline Buysse;  José;  Luí;  s Camargo;  Otá;  vio C. Campoe;  Onur Candan;  Rafaella Canessa;  Nicoletta Cannone;  Michele Carbognani;  Jofre Carnicer;  Angé;  lica Casanova-Katny;  Simone Cesarz;  Bogdan Chojnicki;  Philippe Choler;  Steven L. Chown;  Edgar F. Cifuentes;  Marek Č;  iliak;  Tamara Contador;  Peter Convey;  Elisabeth J. Cooper;  Edoardo Cremonese;  Salvatore R. Curasi;  Robin Curtis;  Maurizio Cutini;  C. Johan Dahlberg;  Gergana N. Daskalova;  Miguel Angel de Pablo;  Stefano Della Chiesa;  ;  rgen Dengler;  Bart Deronde;  Patrice Descombes;  Valter Di Cecco;  Michele Di Musciano;  Jan Dick;  Romina D. Dimarco;  Jiri Dolezal;  Ellen Dorrepaal;  Jiř;  í;  Duš;  ek;  Nico Eisenhauer;  Lars Eklundh;  Todd E. Erickson;  Brigitta Erschbamer;  Werner Eugster;  Robert M. Ewers;  Dan A. Exton;  Nicolas Fanin;  Fatih Fazlioglu;  Iris Feigenwinter;  Giuseppe Fenu;  Olga Ferlian;  M. Rosa Ferná;  ndez Calzado;  Eduardo Ferná;  ndez-Pascual;  Manfred Finckh;  Rebecca Finger Higgens;  T'ai G. W. Forte;  Erika C. Freeman;  Esther R. Frei;  Eduardo Fuentes-Lillo;  Rafael A. Garcí;  a;  Marí;  a B. Garcí;  a;  Charly Gé;  ron;  Mana Gharun;  Dany Ghosn;  Khatuna Gigauri;  Anne Gobin;  Ignacio Goded;  Mathias Goeckede;  Felix Gottschall;  Keith Goulding;  Sanne Govaert;  Bente Jessen Graae;  Sarah Greenwood;  Caroline Greiser;  Achim Grelle;  Benoit Gué;  nard;  Mauro Guglielmin;  Joannè;  s Guillemot;  Peter Haase;  Sylvia Haider;  Aud H. Halbritter;  Maroof Hamid;  Albin Hammerle;  Arndt Hampe;  Siri V. Haugum;  Lucia Hederová;  Bernard Heinesch;  Carole Helfter;  Daniel Hepenstrick;  Maximiliane Herberich;  Mathias Herbst;  Luise Hermanutz;  David S. Hik;  Raú;  l Hoffré;  n;  ;  rgen Homeier;  Lukas Hö;  rtnagl;  Toke T. Hø;  ye;  Filip Hrbacek;  Kristoffer Hylander;  Hiroki Iwata;  Marcin Antoni Jackowicz-Korczynski;  Hervé;  Jactel;  ;  rvi Jä;  rveoja;  Szymon Jastrzę;  bowski;  Anke Jentsch;  Juan J. Jimé;  nez;  Ingibjö;  rg S. Jó;  nsdó;  ttir;  Tommaso Jucker;  Alistair S. Jump;  Radoslaw Juszczak;  ;  bert Kanka;  ;  t Kaš;  par;  George Kazakis;  Julia Kelly;  Anzar A. Khuroo;  Leif Klemedtsson;  Marcin Klisz;  Natascha Kljun;  Alexander Knohl;  Johannes Kobler;  Jozef Kollá;  r;  Martyna M. Kotowska;  Bence Ková;  cs;  Juergen Kreyling;  Andrea Lamprecht;  Simone I. Lang;  Christian Larson;  Keith Larson;  Kamil Laska;  Guerric le Maire;  Rachel I. Leihy;  Luc Lens;  Bengt Liljebladh;  Annalea Lohila;  Juan Lorite;  Benjamin Loubet;  Joshua Lynn;  Martin Macek;  Roy Mackenzie;  Enzo Magliulo;  Regine Maier;  Francesco Malfasi;  Františ;  ek Má;  liš;  Matě;  j Man;  Giovanni Manca;  Antonio Manco;  Tanguy Manise;  Paraskevi Manolaki;  Felipe Marciniak;  Radim Matula;  Ana Clara Mazzolari;  Sergiy Medinets;  Volodymyr Medinets;  Camille Meeussen;  Sonia Merinero;  Rita de Cá;  ssia Guimarã;  es Mesquita;  Katrin Meusburger;  Filip J. R. Meysman;  Sean T. Michaletz;  Ann Milbau;  Dmitry Moiseev;  Pavel Moiseev;  Andrea Mondoni;  Ruth Monfries;  Leonardo Montagnani;  Mikel Moriana-Armendariz;  Umberto Morra di Cella;  Martin Mö;  rsdorf;  Jonathan R. Mosedale;  Lena Muffler;  Miriam Muñ;  oz-Rojas;  Jonathan A. Myers;  Isla H. Myers-Smith;  Laszlo Nagy;  Marianna Nardino;  Ilona Naujokaitis-Lewis;  Emily Newling;  Lena Nicklas;  Georg Niedrist;  Armin Niessner;  Mats B. Nilsson;  Signe Normand;  Marcelo D. Nosetto;  Yann Nouvellon;  Martin A. Nuñ;  ez;  Romà;  Ogaya;  ;  ;  me Ogé;  e;  Joseph Okello;  Janusz Olejnik;  ;  rgen Eivind Olesen;  Ø;  ystein H. Opedal;  Simone Orsenigo;  Andrej Palaj;  Timo Pampuch;  Alexey V. Panov;  Meelis Pä;  rtel;  Ada Pastor;  Aní;  bal Pauchard;  Harald Pauli;  Marian Pavelka;  William D. Pearse;  Matthias Peichl;  Loï;  c Pellissier;  Rachel M. Penczykowski;  Josep Penuelas;  Matteo Petit Bon;  Alessandro Petraglia;  Shyam S. Phartyal;  Gareth K. Phoenix;  Casimiro Pio;  Andrea Pitacco;  Camille Pitteloud;  Roman Plichta;  Francesco Porro;  Miguel Portillo-Estrada;  ;  ;  me Poulenard;  Rafael Poyatos;  Anatoly S. Prokushkin;  Radoslaw Puchalka;  Mihai Puș;  caș;  Dajana Radujković;  Krystal Randall;  Amanda Ratier Backes;  Sabine Remmele;  Wolfram Remmers;  David Renault;  Anita C. Risch;  Christian Rixen;  Sharon A. Robinson;  Bjorn J. M. Robroek;  Adrian V. Rocha;  Christian Rossi;  Graziano Rossi;  Olivier Roupsard;  Alexey V. Rubtsov;  Patrick Saccone;  Clotilde Sagot;  Jhonatan Sallo Bravo;  Cinthya C. Santos;  Judith M. Sarneel;  Tobias Scharnweber;  Jonas Schmeddes;  Marius Schmidt;  Thomas Scholten;  Max Schuchardt;  Naomi Schwartz;  Tony Scott;  Julia Seeber;  Ana Cristina Segalin de Andrade;  Tim Seipel;  Philipp Semenchuk;  Rebecca A. Senior;  Josep M. Serra-Diaz;  Piotr Sewerniak;  Ankit Shekhar;  Nikita V. Sidenko;  Lukas Siebicke;  Laura Siegwart Collier;  Elizabeth Simpson;  David P. Siqueira;  Zuzana Sitková;  Johan Six;  Marko Smiljanic;  Stuart W. Smith;  Sarah Smith-Tripp;  Ben Somers;  Mia Vedel Sø;  rensen;  José;  Joã;  o L. L. Souza;  Bartolomeu Israel Souza;  Arildo Souza Dias;  Marko J. Spasojevic;  James D. M. Speed;  Fabien Spicher;  Angela Stanisci;  Klaus Steinbauer;  Rainer Steinbrecher;  Michael Steinwandter;  Michael Stemkovski;  ;  rg G. Stephan;  Christian Stiegler;  Stefan Stoll;  Martin Svá;  tek;  Miroslav Svoboda;  Torbern Tagesson;  Andrew J. Tanentzap;  Franziska Tanneberger;  Jean-Paul Theurillat;  Haydn J. D. Thomas;  Andrew D. Thomas;  Katja Tielbö;  rger;  Marcello Tomaselli;  Urs Albert Treier;  Mario Trouillier;  Pavel Dan Turtureanu;  Rosamond Tutton;  Vilna A. Tyystjä;  rvi;  Masahito Ueyama;  Karol Ujhá;  zy;  Mariana Ujhá;  zyová;  Domas Uogintas;  Anastasiya V. Urban;  Josef Urban;  Marek Urbaniak;  Tudor-Mihai Ursu;  Francesco Primo Vaccari;  Stijn Van de Vondel;  Liesbeth van den Brink;  Maarten Van Geel;  Vigdis Vandvik;  Pieter Vangansbeke;  Andrej Varlagin;  G. F. Veen;  Elmar Veenendaal;  Susanna E. Venn;  Hans Verbeeck;  Erik Verbrugggen;  Frank G. A. Verheijen;  Luis Villar;  Luca Vitale;  Pascal Vittoz;  Maria Vives-Ingla;  Jonathan von Oppen;  Josefine Walz;  Runxi Wang;  Yifeng Wang;  Robert G. Way;  Ronja E. M. Wedegä;  rtner;  Robert Weigel;  Jan Wild;  Matthew Wilkinson;  Martin Wilmking;  Lisa Wingate;  Manuela Winkler;  Sonja Wipf;  Georg Wohlfahrt;  Georgios Xenakis;  Yan Yang;  Zicheng Yu;  Kailiang Yu;  Florian Zellweger;  Jian Zhang;  Zhaochen Zhang;  Peng Zhao;  Klaudia Ziembliń;  ska;  Reiner Zimmermann;  Shengwei Zong;  Viacheslav I. Zyryanov;  Ivan Nijs;  Jonathan Lenoir
收藏  |  浏览/下载:161/0  |  提交时间:2022/02/23
Noninvasive Dual-Modality Photoacoustic-Ultrasonic Imaging to Detect Mammalian Embryo Abnormalities after Prenatal Exposure to Methylmercury Chloride (MMC): A Mouse Study 期刊论文
Environmental Health Perspectives, 2022
作者:  Qi Qiu;  Yali Huang;  Bei Zhang;  Doudou Huang;  Xin Chen;  Zhongxiong Fan;  Jinpei Lin;  Wensheng Yang;  Kai Wang;  Ning Qu;  Juan Li;  Zhihong Li;  Jingyu Huang;  Shenrui Li;  Jiaxing Zhang;  Gang Liu;  Gang Rui;  Xiaoyuan Chen;  Qingliang Zhao
收藏  |  浏览/下载:65/0  |  提交时间:2022/02/16
Sediment routing and anthropogenic impact in the Huanghe River catchment, China: an investigation using Nd isotopes of river sediments 期刊论文
Water Resources Research, 2021
作者:  Yulong Guo;  Chao Li;  Chenyu Wang;  Juan Xu;  Chenyang Jin;  Shouye Yang
收藏  |  浏览/下载:26/0  |  提交时间:2021/09/14
Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus 期刊论文
Science, 2021
作者:  Yongkun Chen;  Laura Graf;  Tao Chen;  Qijun Liao;  Tian Bai;  Philipp P. Petric;  Wenfei Zhu;  Lei Yang;  Jie Dong;  Jian Lu;  Ying Chen;  Juan Shen;  Otto Haller;  Peter Staeheli;  Georg Kochs;  Dayan Wang;  Martin Schwemmle;  Yuelong Shu
收藏  |  浏览/下载:45/0  |  提交时间:2021/08/25
Perceptions of the appropriate response to norm violation in 57 societies 期刊论文
Nature Communications, 2021
作者:  Kimmo Eriksson;  Pontus Strimling;  Michele Gelfand;  Junhui Wu;  Jered Abernathy;  Charity S. Akotia;  Alisher Aldashev;  Per A. Andersson;  Giulia Andrighetto;  Adote Anum;  Gizem Arikan;  Zeynep Aycan;  Fatemeh Bagherian;  Davide Barrera;  Dana Basnight-Brown;  Birzhan Batkeyev;  Anabel Belaus;  Elizaveta Berezina;  Marie Bjö;  rnstjerna;  Sheyla Blumen;  Paweł;  Boski;  Fouad Bou Zeineddine;  Inna Bovina;  Bui Thi Thu Huyen;  Juan-Camilo Cardenas;  Đ;  orđ;  e Č;  ekrlija;  Hoon-Seok Choi;  Carlos C. Contreras-Ibá;  ñ;  ez;  Rui Costa-Lopes;  ;  cheá;  l de Barra;  Piyanjali de Zoysa;  Angela Dorrough;  Nikolay Dvoryanchikov;  Anja Eller;  Jan B. Engelmann;  Hyun Euh;  Xia Fang;  Susann Fiedler;  Olivia A. Foster-Gimbel;  ;  rta Fü;  ;  p;  Ragna B. Gardarsdottir;  C. M. Hew D. Gill;  Andreas Glö;  ckner;  Sylvie Graf;  Ani Grigoryan;  Vladimir Gritskov;  Katarzyna Growiec;  Peter Halama;  Andree Hartanto;  Tim Hopthrow;  Martina Hř;  ebí;  č;  ková;  Dzintra Iliš;  ko;  Hirotaka Imada;  Hansika Kapoor;  Kerry Kawakami;  Narine Khachatryan;  Natalia Kharchenko;  Ninetta Khoury;  Toko Kiyonari;  Michal Kohú;  t;  ;  Thuỳ;  Linh;  Lisa M. Leslie;  Yang Li;  Norman P. Li;  Zhuo Li;  Kadi Liik;  Angela T. Maitner;  Bernardo Manhique;  Harry Manley;  Imed Medhioub;  Sari Mentser;  Linda Mohammed;  Pegah Nejat;  Orlando Nipassa;  Ravit Nussinson;  Nneoma G. Onyedire;  Ike E. Onyishi;  Seniha Ö;  zden;  Penny Panagiotopoulou;  Lorena R. Perez-Floriano;  Minna S. Persson;  Mpho Pheko;  Anna-Maija Pirttilä;  -Backman;  Marianna Pogosyan;  Jana Raver;  Cecilia Reyna;  Ricardo Borges Rodrigues;  Sara Romanò;  Pedro P. Romero;  Inari Sakki;  Alvaro San Martin;  Sara Sherbaji;  Hiroshi Shimizu;  Brent Simpson;  Erna Szabo;  Kosuke Takemura;  Hassan Tieffi;  Maria Luisa Mendes Teixeira;  Napoj Thanomkul;  Habib Tiliouine;  Giovanni A. Travaglino;  Yannis Tsirbas;  Richard Wan;  Sita Widodo;  Rizqy Zein;  Qing-peng Zhang;  Lina Zirganou-Kazolea;  Paul A. M. Van Lange
收藏  |  浏览/下载:49/0  |  提交时间:2021/03/12
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 期刊论文
Science, 2020
作者:  Qian Zhang;  Paul Bastard;  Zhiyong Liu;  Jérémie Le Pen;  Marcela Moncada-Velez;  Jie Chen;  Masato Ogishi;  Ira K. D. Sabli;  Stephanie Hodeib;  Cecilia Korol;  Jérémie Rosain;  Kaya Bilguvar;  Junqiang Ye;  Alexandre Bolze;  Benedetta Bigio;  Rui Yang;  Andrés Augusto Arias;  Qinhua Zhou;  Yu Zhang;  Fanny Onodi;  Sarantis Korniotis;  Léa Karpf;  Quentin Philippot;  Marwa Chbihi;  Lucie Bonnet-Madin;  Karim Dorgham;  Nikaïa Smith;  William M. Schneider;  Brandon S. Razooky;  Hans-Heinrich Hoffmann;  Eleftherios Michailidis;  Leen Moens;  Ji Eun Han;  Lazaro Lorenzo;  Lucy Bizien;  Philip Meade;  Anna-Lena Neehus;  Aileen Camille Ugurbil;  Aurélien Corneau;  Gaspard Kerner;  Peng Zhang;  Franck Rapaport;  Yoann Seeleuthner;  Jeremy Manry;  Cecile Masson;  Yohann Schmitt;  Agatha Schlüter;  Tom Le Voyer;  Taushif Khan;  Juan Li;  Jacques Fellay;  Lucie Roussel;  Mohammad Shahrooei;  Mohammed F. Alosaimi;  Davood Mansouri;  Haya Al-Saud;  Fahd Al-Mulla;  Feras Almourfi;  Saleh Zaid Al-Muhsen;  Fahad Alsohime;  Saeed Al Turki;  Rana Hasanato;  Diederik van de Beek;  Andrea Biondi;  Laura Rachele Bettini;  Mariella D’Angio’;  Paolo Bonfanti;  Luisa Imberti;  Alessandra Sottini;  Simone Paghera;  Eugenia Quiros-Roldan;  Camillo Rossi;  Andrew J. Oler;  Miranda F. Tompkins;  Camille Alba;  Isabelle Vandernoot;  Jean-Christophe Goffard;  Guillaume Smits;  Isabelle Migeotte;  Filomeen Haerynck;  Pere Soler-Palacin;  Andrea Martin-Nalda;  Roger Colobran;  Pierre-Emmanuel Morange;  Sevgi Keles;  Fatma Çölkesen;  Tayfun Ozcelik;  Kadriye Kart Yasar;  Sevtap Senoglu;  Şemsi Nur Karabela;  Carlos Rodríguez-Gallego;  Giuseppe Novelli;  Sami Hraiech;  Yacine Tandjaoui-Lambiotte;  Xavier Duval;  Cédric Laouénan;  COVID-STORM Clinicians†;  COVID Clinicians†;  Imagine COVID Group†;  French COVID Cohort Study Group†;  CoV-Contact Cohort†;  Amsterdam UMC Covid-19 Biobank†;  COVID Human Genetic Effort†;  NIAID-USUHS/TAGC COVID Immunity Group†;  Andrew L. Snow;  Clifton L. Dalgard;  Joshua D. Milner;  Donald C. Vinh;  Trine H. Mogensen;  Nico Marr;  András N. Spaan;  Bertrand Boisson;  Stéphanie Boisson-Dupuis;  Jacinta Bustamante;  Anne Puel;  Michael J. Ciancanelli;  Isabelle Meyts;  Tom Maniatis;  Vassili Soumelis;  Ali Amara;  Michel Nussenzweig;  Adolfo García-Sastre;  Florian Krammer;  Aurora Pujol;  Darragh Duffy;  Richard P. Lifton;  Shen-Ying Zhang;  Guy Gorochov;  Vivien Béziat;  Emmanuelle Jouanguy;  Vanessa Sancho-Shimizu;  Charles M. Rice;  Laurent Abel;  Luigi D. Notarangelo;  Aurélie Cobat;  Helen C. Su;  Jean-Laurent Casanova
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Economics in the Age of COVID-19 期刊论文
NATURE, 2020, 581 (7809) : 375-377
作者:  Yin, Juan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Yang, Meng;  Cao, Yuan;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Shuang-Lin;  Shu, Rong;  Huang, Yong-Mei;  Deng, Lei;  Li, Li;  Zhang, Qiang;  Liu, Nai-Le
收藏  |  浏览/下载:48/0  |  提交时间:2020/07/03

Breakneck triage nails many diagnoses, but deeper treatment is needed.


Breakneck triage nails many diagnoses, but deeper treatment is needed.


  
The water lily genome and the early evolution of flowering plants 期刊论文
NATURE, 2020, 577 (7788) : 79-+
作者:  Zhang, Liangsheng;  Chen, Fei;  Zhang, Xingtan;  Li, Zhen;  Zhao, Yiyong;  Lohaus, Rolf;  Chang, Xiaojun;  Dong, Wei;  Ho, Simon Y. W.;  Liu, Xing;  Song, Aixia;  Chen, Junhao;  Guo, Wenlei;  Wang, Zhengjia;  Zhuang, Yingyu;  Wang, Haifeng;  Chen, Xuequn;  Hu, Juan;  Liu, Yanhui;  Qin, Yuan;  Wang, Kai;  Dong, Shanshan;  Liu, Yang;  Zhang, Shouzhou;  Yu, Xianxian;  Wu, Qian;  Wang, Liangsheng;  Yan, Xueqing;  Jiao, Yuannian;  Kong, Hongzhi;  Zhou, Xiaofan;  Yu, Cuiwei;  Chen, Yuchu;  Li, Fan;  Wang, Jihua;  Chen, Wei;  Chen, Xinlu;  Jia, Qidong;  Zhang, Chi;  Jiang, Yifan;  Zhang, Wanbo;  Liu, Guanhua;  Fu, Jianyu;  Chen, Feng;  Ma, Hong;  Van de Peer, Yves;  Tang, Haibao
收藏  |  浏览/下载:49/0  |  提交时间:2020/07/03

Water lilies belong to the angiosperm order Nymphaeales. Amborellales, Nymphaeales and Austrobaileyales together form the so-called ANA-grade of angiosperms, which are extant representatives of lineages that diverged the earliest from the lineage leading to the extant mesangiosperms(1-3). Here we report the 409-megabase genome sequence of the blue-petal water lily (Nymphaea colorata). Our phylogenomic analyses support Amborellales and Nymphaeales as successive sister lineages to all other extant angiosperms. The N. colorata genome and 19 other water lily transcriptomes reveal a Nymphaealean whole-genome duplication event, which is shared by Nymphaeaceae and possibly Cabombaceae. Among the genes retained from this whole-genome duplication are homologues of genes that regulate flowering transition and flower development. The broad expression of homologues of floral ABCE genes in N. colorata might support a similarly broadly active ancestral ABCE model of floral organ determination in early angiosperms. Water lilies have evolved attractive floral scents and colours, which are features shared with mesangiosperms, and we identified their putative biosynthetic genes in N. colorata. The chemical compounds and biosynthetic genes behind floral scents suggest that they have evolved in parallel to those in mesangiosperms. Because of its unique phylogenetic position, the N. colorata genome sheds light on the early evolution of angiosperms.


  
Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
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Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.


  
Assessing Noah-MP Parameterization Sensitivity and Uncertainty Interval Across Snow Climates 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (4)
作者:  You, Yuanhong;  Huang, Chunlin;  Yang, Zongliang;  Zhang, Ying;  Bai, Yulong;  Gu, Juan
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/02