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Long-term decrease in Asian monsoon rainfall and abrupt climate change events over the past 6,700 years 期刊论文
Proceedings of the National Academy of Sciences, 2021
作者:  Bao Yang;  Chun Qin;  Achim Bräuning;  Timothy J. Osborn;  Valerie Trouet;  Fredrik Charpentier Ljungqvist;  Jan Esper;  Lea Schneider;  Jussi Grießinger;  Ulf Büntgen;  Sergio Rossi;  Guanghui Dong;  Mi Yan;  Liang Ning;  Jianglin Wang;  Xiaofeng Wang;  Suming Wang;  Jürg Luterbacher;  Edward R. Cook;  Nils Chr. Stenseth
收藏  |  浏览/下载:55/0  |  提交时间:2021/07/27
Vital roles of soil microbes in driving terrestrial nitrogen immobilization 期刊论文
Global Change Biology, 2021
作者:  Zhaolei Li;  Zhaoqi Zeng;  Zhaopeng Song;  Fuqiang Wang;  Dashuan Tian;  Wenhai Mi;  Xin Huang;  Jinsong Wang;  Lei Song;  Zhongkang Yang;  Jun Wang;  Haojie Feng;  Lifen Jiang;  Ye Chen;  Yiqi Luo;  Shuli Niu
收藏  |  浏览/下载:38/0  |  提交时间:2021/03/12
Can N2O emissions offset the benefits from soil organic carbon storage? 期刊论文
Global Change Biology, 2020
作者:  Bertrand Guenet;  Benoit Gabrielle;  Claire Chenu;  Dominique Arrouays;  ;  ;  me Balesdent;  Martial Bernoux;  Elisa Bruni;  Jean‐;  Pierre Caliman;  ;  mi Cardinael;  Songchao Chen;  Philippe Ciais;  Dominique Desbois;  Julien Fouche;  Stefan Frank;  Catherine Henault;  Emanuele Lugato;  Victoria Naipal;  Thomas Nesme;  Michael Obersteiner;  Sylvain Pellerin;  David S. Powlson;  Daniel P. Rasse;  Fré;  ;  ric Rees;  Jean‐;  Franç;  ois Soussana;  Yang Su;  Hanqin Tian;  Hugo Valin;  Feng Zhou
收藏  |  浏览/下载:39/0  |  提交时间:2020/10/12
Extreme climate after massive eruption of Alaska's Okmok volcano in 43 BCE and effects on the late Roman Republic and Ptolemaic Kingdom 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (27) : 15443-15449
作者:  McConnell, Joseph R.;  Sigl, Michael;  Plunkett, Gill;  Burke, Andrea;  Kim, Woon Mi;  Raible, Christoph C.;  Wilson, Andrew, I;  Manning, Joseph G.;  Ludlow, Francis;  Chellman, Nathan J.;  Innes, Helen M.;  Yang, Zhen;  Larsen, Jessica F.;  Schaefer, Janet R.;  Kipfstuhl, Sepp;  Mojtabavi, Seyedhamidreza;  Wilhelms, Frank;  Opel, Thomas;  Meyer, Hanno;  Steffensen, Jorgen Peder
收藏  |  浏览/下载:47/0  |  提交时间:2020/06/29
ice core  volcano  Okmok  Rome  climate forcing  
Extreme climate after massive eruption of Alaska’s Okmok volcano in 43 BCE and effects on the late Roman Republic and Ptolemaic Kingdom 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Joseph R. McConnell;  Michael Sigl;  Gill Plunkett;  Andrea Burke;  Woon Mi Kim;  Christoph C. Raible;  Andrew I. Wilson;  Joseph G. Manning;  Francis Ludlow;  Nathan J. Chellman;  Helen M. Innes;  Zhen Yang;  Jessica F. Larsen;  Janet R. Schaefer;  Sepp Kipfstuhl;  Seyedhamidreza Mojtabavi;  Frank Wilhelms;  Thomas Opel;  Hanno Meyer;  Jørgen Peder Steffensen
收藏  |  浏览/下载:28/0  |  提交时间:2020/06/29
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 期刊论文
NATURE, 2020, 577 (7788) : 109-+
作者:  Tao, Panfeng;  Sun, Jinqiao;  Wu, Zheming;  Wang, Shihao;  Wang, Jun;  Li, Wanjin;  Pan, Heling;  Bai, Renkui;  Zhang, Jiahui;  Wang, Ying;  Lee, Pui Y.;  Ying, Wenjing;  Zhou, Qinhua;  Hou, Jia;  Wang, Wenjie;  Sun, Bijun;  Yang, Mi;  Liu, Danru;  Fang, Ran;  Han, Huan;  Yang, Zhaohui;  Huang, Xin;  Li, Haibo;  Deuitch, Natalie;  Zhang, Yuan;  Dissanayake, Dilan;  Haude, Katrina;  McWalter, Kirsty;  Roadhouse, Chelsea;  MacKenzie, Jennifer J.;  Laxer, Ronald M.;  Aksentijevich, Ivona;  Yu, Xiaomin;  Wang, Xiaochuan;  Yuan, Junying;  Zhou, Qing
收藏  |  浏览/下载:56/0  |  提交时间:2020/07/03

Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways(1). Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase domain from the intermediate and death domains. The D325A mutation in mouse RIPK1 leads to embryonic lethality during mouse development(2,3). However, the functional importance of blocking caspase-8-mediated cleavage of RIPK1 on RIPK1 activation in humans is unknown. Here we identify two families with variants in RIPK1 (D324V and D324H) that lead to distinct symptoms of recurrent fevers and lymphadenopathy in an autosomaldominant manner. Impaired cleavage of RIPK1 D324 variants by caspase-8 sensitized patients'  peripheral blood mononuclear cells to RIPK1 activation, apoptosis and necroptosis induced by TNF. The patients showed strong RIPK1-dependent activation of inflammatory signalling pathways and overproduction of inflammatory cytokines and chemokines compared with unaffected controls. Furthermore, we show that expression of the RIPK1 mutants D325V or D325H in mouse embryonic fibroblasts confers not only increased sensitivity to RIPK1 activation-mediated apoptosis and necroptosis, but also induction of pro-inflammatory cytokines such as IL-6 and TNF. By contrast, patient-derived fibroblasts showed reduced expression of RIPK1 and downregulated production of reactive oxygen species, resulting in resistance to necroptosis and ferroptosis. Together, these data suggest that human non-cleavable RIPK1 variants promote activation of RIPK1, and lead to an autoinflammatory disease characterized by hypersensitivity to apoptosis and necroptosis and increased inflammatory response in peripheral blood mononuclear cells, as well as a compensatory mechanism to protect against several pro-death stimuli in fibroblasts.


  
Saving less in China facilitates global CO2 mitigation 期刊论文
Nature, 2020
作者:  Chen Lin;  Jianchuan Qi;  Sai Liang;  Cuiyang Feng;  Thomas O. Wiedmann;  Yihan Liao;  Xuechun Yang;  Yumeng Li;  Zhifu Mi;  Zhifeng Yang
收藏  |  浏览/下载:23/0  |  提交时间:2020/05/13
Ice front blocking of ocean heat transport to an Antarctic ice shelf 期刊论文
NATURE, 2020, 578 (7796) : 568-+
作者:  Alexandrov, Ludmil B.;  Kim, Jaegil;  Haradhvala, Nicholas J.;  Huang, Mi Ni;  Ng, Alvin Wei Tian;  Wu, Yang;  Boot, Arnoud;  Covington, Kyle R.;  Gordenin, Dmitry A.;  Bergstrom, Erik N.;  Islam, S. M. Ashiqul;  Lopez-Bigas, Nuria;  Klimczak, Leszek J.;  McPherson, John R.;  Morganella, Sandro;  Sabarinathan, Radhakrishnan;  Wheeler, David A.;  Mustonen, Ville;  Getz, Gad;  Rozen, Steven G.;  Stratton, Michael R.
收藏  |  浏览/下载:39/0  |  提交时间:2020/05/13

The front of the Getz Ice Shelf in West Antarctica creates an abrupt topographic step that deflects ocean currents, suppressing 70% of the heat delivery to the ice sheet.


Mass loss from the Antarctic Ice Sheet to the ocean has increased in recent decades, largely because the thinning of its floating ice shelves has allowed the outflow of grounded ice to accelerate(1,2). Enhanced basal melting of the ice shelves is thought to be the ultimate driver of change(2,3), motivating a recent focus on the processes that control ocean heat transport onto and across the seabed of the Antarctic continental shelf towards the ice(4-6). However, the shoreward heat flux typically far exceeds that required to match observed melt rates(2,7,8), suggesting that other critical controls exist. Here we show that the depth-independent (barotropic) component of the heat flow towards an ice shelf is blocked by the marked step shape of the ice front, and that only the depth-varying (baroclinic) component, which is typically much smaller, can enter the sub-ice cavity. Our results arise from direct observations of the Getz Ice Shelf system and laboratory experiments on a rotating platform. A similar blocking of the barotropic component may occur in other areas with comparable ice-bathymetry configurations, which may explain why changes in the density structure of the water column have been found to be a better indicator of basal melt rate variability than the heat transported onto the continental shelf(9). Representing the step topography of the ice front accurately in models is thus important for simulating ocean heat fluxes and induced melt rates.


  
The evolutionary history of 2,658 cancers 期刊论文
NATURE, 2020, 578 (7793) : 122-+
作者:  Tao, Panfeng;  Sun, Jinqiao;  Wu, Zheming;  Wang, Shihao;  Wang, Jun;  Li, Wanjin;  Pan, Heling;  Bai, Renkui;  Zhang, Jiahui;  Wang, Ying;  Lee, Pui Y.;  Ying, Wenjing;  Zhou, Qinhua;  Hou, Jia;  Wang, Wenjie;  Sun, Bijun;  Yang, Mi;  Liu, Danru;  Fang, Ran;  Han, Huan;  Yang, Zhaohui;  Huang, Xin;  Li, Haibo;  Deuitch, Natalie;  Zhang, Yuan;  Dissanayake, Dilan;  Haude, Katrina;  McWalter, Kirsty;  Roadhouse, Chelsea;  MacKenzie, Jennifer J.;  Laxer, Ronald M.;  Aksentijevich, Ivona;  Yu, Xiaomin;  Wang, Xiaochuan;  Yuan, Junying;  Zhou, Qing
收藏  |  浏览/下载:67/0  |  提交时间:2020/07/03

Cancer develops through a process of somatic evolution(1,2). Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes(3). Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)(4), we reconstruct the life history and evolution of mutational processes and driver mutation sequences of 38 types of cancer. Early oncogenesis is characterized by mutations in a constrained set of driver genes, and specific copy number gains, such as trisomy 7 in glioblastoma and isochromosome 17q in medulloblastoma. The mutational spectrum changes significantly throughout tumour evolution in 40% of samples. A nearly fourfold diversification of driver genes and increased genomic instability are features of later stages. Copy number alterations often occur in mitotic crises, and lead to simultaneous gains of chromosomal segments. Timing analyses suggest that driver mutations often precede diagnosis by many years, if not decades. Together, these results determine the evolutionary trajectories of cancer, and highlight opportunities for early cancer detection.


  
Temporal population variability in local forest communities has mixed effects on tree species richness across a latitudinal gradient 期刊论文
ECOLOGY LETTERS, 2019
作者:  Fung, Tak;  Chisholm, Ryan A.;  Anderson-Teixeira, Kristina;  Bourg, Norm;  Brockelman, Warren Y.;  Bunyavejchewin, Sarayudh;  Chang-Yang, Chia-Hao;  Chitra-Tarak, Rutuja;  Chuyong, George;  Condit, Richard;  Dattaraja, Handanakere S.;  Davies, Stuart J.;  Ewango, Corneille E. N.;  Fewless, Gary;  Fletcher, Christine;  Gunatilleke, C. V. Savitri;  Gunatilleke, I. A. U. Nimal;  Hao, Zhanqing;  Hogan, J. Aaron;  Howe, Robert;  Hsieh, Chang-Fu;  Kenfack, David;  Lin, YiChing;  Ma, Keping;  Makana, Jean-Remy;  McMahon, Sean;  McShea, William J.;  Mi, Xiangcheng;  Nathalang, Anuttara;  Ong, Perry S.;  Parker, Geoffrey;  Rau, E-Ping;  Shue, Jessica;  Su, Sheng-Hsin;  Sukumar, Raman;  Sun, I-Fang;  Suresh, Hebbalalu S.;  Tan, Sylvester;  Thomas, Duncan;  Thompson, Jill;  Valencia, Renato;  Vallejo, Martha I.;  Wang, Xugao;  Wang, Yunquan;  Wijekoon, Pushpa;  Wolf, Amy;  Yap, Sandra;  Zimmerman, Jess
收藏  |  浏览/下载:39/0  |  提交时间:2020/02/17
Biodiversity  environmental variance  extinction risk  stochastic model  storage effect  temporal niche partitioning