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Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载：160/0  |  提交时间：2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
Household energy elasticities and policy implications for Pakistan 期刊论文
ENERGY POLICY, 2018, 113: 633-642
作者:  Irfan, Muhammad;  Cameron, Michael P.;  Hassan, Gazi
收藏  |  浏览/下载：13/0  |  提交时间：2019/04/09
Household energy  Elasticities  LA-AIDS  Pakistan  
The direct and indirect CO2 rebound effect for private cars in China 期刊论文
ENERGY POLICY, 2017, 100
作者:  Zhang, Yue-Jun;  Liu, Zhao;  Qin, Chang-Xiong;  Tan, Tai-De
收藏  |  浏览/下载：15/0  |  提交时间：2019/04/09
Carbon emission  Private cars  CO2 rebound effect  AIDS model  
Rebound effect of efficiency improvement in passenger cars on gasoline consumption in Canada 期刊论文
ECOLOGICAL ECONOMICS, 2017, 131
作者:  Moshiri, Saeed;  Aliyev, Kamil
收藏  |  浏览/下载：13/0  |  提交时间：2019/04/09
Gasoline  Demand  AIDS  QUAIDS  Rebound effect  Canada  
The International AIDS Vaccine Initiative's capacity building activities in East Africa: Evaluating progress and impacts in Kenya, Uganda and Rwanda 科技报告
来源：Rand Corporation. 出版年： 2015
作者:  Gavin Cochrane;  Enora Robin;  Rebecca Hanlin;  Sophie Castle-Clarke;  Calum MacLure;  Sarah Parks;  Joanna Chataway
收藏  |  浏览/下载：33/0  |  提交时间：2019/04/05
Science, Technology and Innovation Policy  HIV and AIDS  Health Care Program Evaluation  Capacity Building  Vaccination  Kenya  Rwanda  Uganda  
Mapping Pathways: Developing evidence-based, people-centred strategies for the use of antiretrovirals as prevention 科技报告
来源：Rand Corporation. 出版年： 2013
作者:  ꙸĿ뎈Ŀandra Pollitt;  Stephanie Diepeveen;  Susan Guthrie;  Molly Morgan Jones;  Siobhan Ni ChMolly Morgan Jones;  Jim Pickett;  Joanna Chataway;  James Swartz;  Ohid Yaqub;  Philip Smith;  Kartika Palar;  Jessica Terlikowski;  Daniella Mark;  William McColl;  et al.
收藏  |  浏览/下载：11/0  |  提交时间：2019/04/05
Evidence Based Health Practice  Economists  Pharmaceutical Drugs  HIV Treatment  HIV and AIDS  
Value for Money in Donor HIV Funding 科技报告
来源：Rand Corporation. 出版年： 2011
作者:  Sebastian Linnemayr;  Gery W. Ryan;  Jenny Liu;  Kartika Palar
收藏  |  浏览/下载：13/0  |  提交时间：2019/04/05
Health Economics  Economists  HIV and AIDS  Global Health  
Source Materials for the Healthy Communities Toolkit: A Resource Guide for Community and Faith-Based Organizations 科技报告
来源：Rand Corporation. 出版年： 2011
作者:  Joie Acosta;  Anita Chandra;  Malcolm Williams;  Lois M. Davis
收藏  |  浏览/下载：14/0  |  提交时间：2019/04/05
Community Organizations  Families  Mental Health and Illness  HIV and AIDS  Chronic Diseases and Conditions  Crime and Violence Prevention  Community Health  Affordable Care Act