中文版 | English

在结果中检索

GSTDTAP

浏览/检索结果: 共5条，第1-5条 帮助

已选(0)清除 条数/页：   排序方式：
Sialylation of immunoglobulin E is a determinant of allergic pathogenicity 期刊论文
NATURE, 2020, 582 (7811) : 265-+
作者:  Abdul-Masih, Michael;  Banyard, Gareth;  Bodensteiner, Julia;  Bordier, Emma;  Bowman, Dominic M.;  Dsilva, Karan;  Fabry, Matthias;  Hawcroft, Calum;  Mahy, Laurent;  Marchant, Pablo;  Raskin, Gert;  Reggiani, Maddalena;  Shenar, Tomer;  Tkachenko, Andrew;  Van Winckel, Hans;  Vermeylen, Lore;  Sana, Hugues
收藏  |  浏览/下载：23/0  |  提交时间：2020/07/03

A specific type of glycosylation-sialylation-is more common on immunoglobulin E from individuals with a peanut allergys than from non-atopic people, suggesting that it has a role in regulating anaphylaxis.


Approximately one-third of the world'  s population suffers from allergies(1). Exposure to allergens crosslinks immunoglobulin E (IgE) antibodies that are bound to mast cells and basophils, triggering the release of inflammatory mediators, including histamine(2). Although IgE is absolutely required for allergies, it is not understood why total and allergen-specific IgE concentrations do not reproducibly correlate with allergic disease(3-5). It is well-established that glycosylation of IgG dictates its effector function and has disease-specific patterns. However, whether IgE glycans differ in disease states or affect biological activity is completely unknown(6). Here we perform an unbiased examination of glycosylation patterns of total IgE from individuals with a peanut allergy and from non-atopic individuals without allergies. Our analysis reveals an increase in sialic acid content on total IgE from individuals with a peanut allergy compared with non-atopic individuals. Removal of sialic acid from IgE attenuates effector-cell degranulation and anaphylaxis in several functional models of allergic disease. Therapeutic interventions-including removing sialic acid from cell-bound IgE with a neuraminidase enzyme targeted towards the IgE receptor Fc epsilon RI, and administering asialylated IgE-markedly reduce anaphylaxis. Together, these results establish IgE glycosylation, and specifically sialylation, as an important regulator of allergic disease.


  
Prediction of airborne pollen concentrations for the plane tree as a tool for evaluating allergy risk in urban green areas 期刊论文
LANDSCAPE AND URBAN PLANNING, 2019, 189: 285-295
作者:  Lara, Beatriz;  Rojo, Jesus;  Fernandez-Gonzalez, Federico;  Perez-Badia, Rosa
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Plane tree pollen  Allergy risk  Meteorological variables  Forecasting model  Time series analysis  
Northern Hemisphere forests at temperate and boreal latitudes are substantial pollen contributors to atmospheric bioaerosols 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2017, 401
作者:  Williams, Claire G.;  Despres, Viviane
收藏  |  浏览/下载：11/0  |  提交时间：2019/04/09
Pollen dispersal  Pollen allergy  Palynology  Climate change  long-range transport (LRT)  long-distance dispersal (LDD)  Clouds microphysics  Water cycle  Primary atmospheric biological particles (PBAP)  Atmospheric aerosols  Bioprecipitation  Global circulation models (GCM)  
The UK's largest UK University Fair for International Students 会议
London, United Kingdom, 会议类型: Exhibition, 2017