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大堡礁鱼类证据表明全球主要生物多样性模式发生了变化 快报文章
资源环境快报,2025年第2期
作者:  魏艳红
Microsoft Word(16Kb)  |  收藏  |  浏览/下载:475/1  |  提交时间:2025/01/31
Great Barrier Reef  Fish Diversity  Coral Species Composition  
澳大利亚研究人员借助数字孪生技术推进大堡礁管理与恢复 快报文章
资源环境快报,2023年第14期
作者:  薛明媚,王金平
Microsoft Word(16Kb)  |  收藏  |  浏览/下载:619/1  |  提交时间:2023/07/31
Digital Twins,Great Barrier Reef,Artificial Intelligence  
AIMS发布《2020/2021年珊瑚礁状况年度总结报告》 快报文章
资源环境快报,2021年第15期
作者:  薛明媚,王金平
Microsoft Word(16Kb)  |  收藏  |  浏览/下载:509/1  |  提交时间:2021/08/16
Great Barrier Reef  Heat Stress  Coral Reef  
EEA发布报告关注水相关的可持续发展 快报文章
资源环境快报,2021年第5期
作者:  吴秀平
Microsoft Word(16Kb)  |  收藏  |  浏览/下载:455/0  |  提交时间:2021/03/15
European river barrier  river ecosystem  water and agriculture  sustainable solution  
Spring Barrier to the MJO Eastward Propagation 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Li, Kuiping;  Yu, Weidong;  Yang, Yang;  Feng, Lin;  Liu, Shouhua;  Li, Lili
收藏  |  浏览/下载:29/0  |  提交时间:2020/06/16
MJO  Maritime Continent  barrier  
El Nino Diversity Across Boreal Spring Predictability Barrier 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Wang, Bin;  Luo, Xiao;  Sun, Weiyi;  Yang, Young-Min;  Liu, Jian
收藏  |  浏览/下载:41/0  |  提交时间:2020/06/16
El Nino diversity  El Nino transition  k-means cluster analysis  El Nino precursors  El Nino impact  spring predictability barrier  
Controls of Spring Persistence Barrier Strength in Different ENSO Regimes and Implications for 21st Century Changes 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (11)
作者:  Jin, Yishuai;  Lu, Zhengyao;  Liu, Zhengyu
收藏  |  浏览/下载:28/0  |  提交时间:2020/05/25
ENSO growth rate  seasonal persistence barrier strength  Bjerknes stability index  thermodynamic damping  thermocline  
Physical Diagnosis of the 2016 Great Barrier Reef Bleaching Event 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (11)
作者:  Karnauskas, Kristopher B.
收藏  |  浏览/下载:24/0  |  提交时间:2020/05/20
Marine heatwaves  Coral bleaching  Great Barrier Reef  Sea surface temperature  El Nino  Climate change  
A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases 期刊论文
NATURE, 2020, 577 (7789) : 244-+
作者:  Mendoza, Senen D.;  Nieweglowska, Eliza S.;  Govindarajan, Sutharsan;  Leon, Lina M.;  Berry, Joel D.;  Tiwari, Anika;  Chaikeeratisak, Vorrapon;  Pogliano, Joe;  Agard, David A.;  Bondy-Denomy, Joseph
收藏  |  浏览/下载:33/0  |  提交时间:2020/07/03

All viruses require strategies to inhibit or evade the immune pathways of cells that they infect. The viruses that infect bacteria, bacteriophages (phages), must avoid immune pathways that target nucleic acids, such as CRISPR-Cas and restriction-modification systems, to replicate efficiently(1). Here we show that jumbo phage phi KZ segregates its DNA from immunity nucleases of its host, Pseudomonas aeruginosa, by constructing a proteinaceous nucleus-like compartment. phi KZ is resistant to many immunity mechanisms that target DNA in vivo, including two subtypes of CRISPR-Cas3, Cas9, Cas12a and the restriction enzymes HsdRMS and EcoRI. Cas proteins and restriction enzymes are unable to access the phage DNA throughout the infection, but engineering the relocalization of EcoRI inside the compartment enables targeting of the phage and protection of host cells. Moreover, phi KZ is sensitive to Cas13a-a CRISPR-Cas enzyme that targets RNA-probably owing to phage mRNA localizing to the cytoplasm. Collectively, we propose that Pseudomonas jumbo phages evade a broad spectrum of DNA-targeting nucleases through the assembly of a protein barrier around their genome.


  
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline 期刊论文
NATURE, 2020, 581 (7806) : 70-+
作者:  Doherty, Tiarnan A. S.;  Winchester, Andrew J.;  Macpherson, Stuart;  Johnstone, Duncan N.;  Pareek, Vivek;  Tennyson, Elizabeth M.;  Kosar, Sofiia;  Kosasih, Felix U.;  Anaya, Miguel;  Abdi-Jalebi, Mojtaba;  Andaji-Garmaroudi, Zahra;  Wong, E. Laine;  Madeo, Julien;  Chiang, Yu-Hsien;  Park, Ji-Sang;  Jung, Young-Kwang;  Petoukhoff, Christopher E.;  Divitini, Giorgio;  Man, Michael K. L.;  Ducati, Caterina;  Walsh, Aron;  Midgley, Paul A.;  Dani, Keshav M.;  Stranks, Samuel D.
收藏  |  浏览/下载:56/0  |  提交时间:2020/07/03

Breakdown of the blood-brain barrier in individuals carrying the epsilon 4 allele of the APOE gene, but not the epsilon 3 allele, increases with and predicts cognitive impairment and is independent of amyloid beta or tau pathology.


Vascular contributions to dementia and Alzheimer'  s disease are increasingly recognized(1-6). Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction(7), including the early clinical stages of Alzheimer'  s disease(5,8-10). The E4 variant of apolipoprotein E (APOE4), the main susceptibility gene for Alzheimer'  s disease(11-14), leads to accelerated breakdown of the BBB and degeneration of brain capillary pericytes(15-19), which maintain BBB integrity(20-22). It is unclear, however, whether the cerebrovascular effects of APOE4 contribute to cognitive impairment. Here we show that individuals bearing APOE4 (with the epsilon 3/epsilon 4 or epsilon 4/epsilon 4 alleles) are distinguished from those without APOE4 (epsilon 3/epsilon 3) by breakdown of the BBB in the hippocampus and medial temporal lobe. This finding is apparent in cognitively unimpaired APOE4 carriers and more severe in those with cognitive impairment, but is not related to amyloid-beta or tau pathology measured in cerebrospinal fluid or by positron emission tomography(23). High baseline levels of the BBB pericyte injury biomarker soluble PDGFR beta(7,8) in the cerebrospinal fluid predicted future cognitive decline in APOE4 carriers but not in non-carriers, even after controlling for amyloid-beta and tau status, and were correlated with increased activity of the BBB-degrading cyclophilin A-matrix metalloproteinase-9 pathway(19) in cerebrospinal fluid. Our findings suggest that breakdown of the BBB contributes to APOE4-associated cognitive decline independently of Alzheimer'  s disease pathology, and might be a therapeutic target in APOE4 carriers.