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Turning connective tissue into neurons for 10 years 期刊论文
NATURE, 2020, 578 (7796) : 522-524
作者:  Acquaviva, Laurent;  Boekhout, Michiel;  Karasu, Mehmet E.;  Brick, Kevin;  Pratto, Florencia;  Li, Tao;  van Overbeek, Megan;  Kauppi, Liisa;  Camerini-Otero, R. Daniel;  Jasin, Maria;  Keeney, Scott
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/03

An historic breakthrough that altered our understanding of cell fate.


A method for directly converting connective-tissue cells into neurons opened up a new branch of research into cell-based therapies and called into question long-held beliefs about how development affects a cell'  s identity.


  
Molecular architecture of the human 17S U2 snRNP 期刊论文
NATURE, 2020, 583 (7815) : 310-+
作者:  Muench, David E.;  Olsson, Andre;  Ferchen, Kyle;  Pham, Giang;  Serafin, Rachel A.;  Chutipongtanate, Somchai;  Dwivedi, Pankaj;  Song, Baobao;  Hay, Stuart;  Chetal, Kashish;  Trump-Durbin, Lisa R.;  Mookerjee-Basu, Jayati;  Zhang, Kejian;  Yu, Jennifer C.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/03

The U2 small nuclear ribonucleoprotein (snRNP) has an essential role in the selection of the precursor mRNA branch-site adenosine, the nucleophile for the first step of splicing'  . Stable addition of U2 during early spliceosome formation requiresthe DEAD-box ATPase PRP5(2-7). Yeast U2 small nuclear RNA (snRNA) nucleotides that form base pairs with the branch site are initially sequestered in a branchpoint-interacting stem-loop (BSL)(8), but whether the human U2 snRNA folds in a similar manner is unknown. The U2 SF3B1 protein, a common mutational target in haematopoietic cancers(9), contains a HEAT domain (SF3B1(HEAT)) with an open conformation in isolated SF3b(10), but a closed conformation in spliceosomes(11), which is required for stable interaction between U2 and the branch site. Here we report a 3D cryo-electron microscopy structure ofthe human 17S U2 snRNP at a core resolution of 4.1 angstrom and combine it with protein crosslinking data to determine the molecular architecture of this snRNP. Our structure reveals that SF3B1(HEAT) interacts with PRP5 and TAT-SF1, and maintains its open conformation in U2 snRNP, and that U2 snRNA forms a BSL that is sandwiched between PRP5, TAT-SF1 and SF3B1(HEAT). Thus, substantial remodelling of the BSL and displacement of BSL-interacting proteins must occur to allow formation of the U2-branch-site helix. Our studies provide a structural explanation of why TAT-SF1 must be displaced before the stable addition of U2 to the spliceosome, and identify RNP rearrangements facilitated by PRP5 that are required for stable interaction between U2 and the branch site.


  
Dualities and non-Abelian mechanics 期刊论文
NATURE, 2020, 577 (7792) : 636-+
作者:  Song, Xinyang;  Sun, Ximei;  Oh, Sungwhan F.;  Wu, Meng;  Zhang, Yanbo;  Zheng, Wen;  Geva-Zatorsky, Naama;  Jupp, Ray;  Mathis, Diane;  Benoist, Christophe;  Kasper, Dennis L.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/03

Dualities-mathematical mappings between different systems-can act as hidden symmetries that enable materials design beyond that suggested by crystallographic space groups.


Dualities are mathematical mappings that reveal links between apparently unrelated systems in virtually every branch of physics(1-8). Systems mapped onto themselves by a duality transformation are called self-dual and exhibit remarkable properties, as exemplified by the scale invariance of an Ising magnet at the critical point. Here we show how dualities can enhance the symmetries of a dynamical matrix (or Hamiltonian), enabling the design of metamaterials with emergent properties that escape a standard group theory analysis. As an illustration, we consider twisted kagome lattices(9-15), reconfigurable mechanical structures that change shape by means of a collapse mechanism(9). We observe that pairs of distinct configurations along the mechanism exhibit the same vibrational spectrum and related elastic moduli. We show that these puzzling properties arise from a duality between pairs of configurations on either side of a mechanical critical point. The critical point corresponds to a self-dual structure with isotropic elasticity even in the absence of spatial symmetries and a twofold-degenerate spectrum over the entire Brillouin zone. The spectral degeneracy originates from a version of Kramers'  theorem(16,17) in which fermionic time-reversal invariance is replaced by a hidden symmetry emerging at the self-dual point. The normal modes of the self-dual systems exhibit non-Abelian geometric phases(18,19) that affect the semiclassical propagation of wavepackets(20), leading to non-commuting mechanical responses. Our results hold promise for holonomic computation(21) and mechanical spintronics by allowing on-the-fly manipulation of synthetic spins carried by phonons.


  
Aboveground biomass equations for the predominant conifer species of the Inland Northwest USA 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 432: 179-188
作者:  Affleck, David L. R.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Tree biomass equation systems  Inland northwest  Randomized branch sampling  Forest inventory  
Vitality loss of European beech (Fagus sylvatica L.) and infestation by the European beech splendour beetle (Agrilus viridis L., Buprestidae, Coleoptera) 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 432: 150-156
作者:  Brueck-Dyckhoff, Claus;  Petercord, Ralf;  Schopf, Reinhard
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/09
Branch dieback  Sunburn  Trap catch  Survival in latency  Global change  Stand structure  Predisposition  
The voluminous energy transition legal framework in France and the question of its recognition as a branch of law 期刊论文
ENERGY POLICY, 2018, 122: 499-505
作者:  Mauger, Romain
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09
Energy law  Energy transition legal framework  Autonomy of a branch of law  Criteria  
Applying precision triaxial accelerometer to monitor branch sway of an urban tree in a tropical cyclone 期刊论文
LANDSCAPE AND URBAN PLANNING, 2018, 178: 170-182
作者:  Lee, Louis S. H.;  Jim, C. Y.
收藏  |  浏览/下载:24/0  |  提交时间:2019/04/09
Tree Motion Sensor  Tropical cyclone  Tropical urban tree  Branch aerodynamics  Branch sway frequency  Tree risk management  
Discrimination of taxonomic identity at species, genus and family levels using Fourier Transformed Near-Infrared Spectroscopy (FT-NIR) 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2017, 406
作者:  Lang, Carla;  Almeida, Danilo R. A.;  Costa, Flavia R. C.
收藏  |  浏览/下载:23/0  |  提交时间:2019/04/09
Discrimination  Species  Fourier Transformed Near-Infrared  Spectroscopy  Branch  Leaf  
Estimating biomass and carbon for Gilbertiodendron dewevrei (De Wild) Leonard, a dominant canopy tree of African tropical Rainforest: Implications for policies on carbon sequestration 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2017, 404
作者:  Umunay, P. M.;  Gregoire, T. G.;  Ashton, M. S.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Antithetic sampling  Gilbertiodendron dewevrei  Evergreen rainforest  Randomized branch sampling  
Role of NMHSs in adaptation to climate variability and change: (Analysis report of a survey) 科技报告
来源:World Meteorological Organization (WMO). 出版年: 2010
作者:  World Meteorological Organization
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/05
Observations  National Meteorological and Hydrological Service (NMHS)  Climate  Climate change  Adaptation  World Climate Programme (WCP)  - International  Climate and Water Department (CLW)  Climate Prediction and Adaptation Branch (CLPA)