GSTDTAP

浏览/检索结果: 共104条,第1-10条 帮助

已选(0)清除 条数/页:   排序方式:
最新研究揭示地幔过渡带含水区域与火山活动之间的关联机制 快报文章
地球科学快报,2025年第7期
作者:  王晓晨
Microsoft Word(15Kb)  |  收藏  |  浏览/下载:467/0  |  提交时间:2025/04/10
mantle  high water content  volcanic activity  
研究发现岩浆含水量控制火山弧岩浆深度 快报文章
地球科学快报,2022年第06期
作者:  王晓晨
Microsoft Word(14Kb)  |  收藏  |  浏览/下载:660/0  |  提交时间:2022/03/25
water content  magmas depth  
NOAA报告显示2021年是有记录以来的第六热年份 快报文章
气候变化快报,2022年第03期
作者:  董利苹
Microsoft Word(17Kb)  |  收藏  |  浏览/下载:785/0  |  提交时间:2022/02/06
Global Climate  global surface temperature  Ocean Heat Content  Snow  Sea Ice  Tropical Cyclones  
Intra-annual variations of regional total column ozone, aerosol optical depth, and water vapor from ground-based, satellite-based and model-based observations 期刊论文
ATMOSPHERIC RESEARCH, 2020, 237
作者:  Nade, Dada P.;  Potdar, Swapnil S.;  Pawar, Rani P.;  Taori, Alok;  Kulkarni, Gourihar;  Siingh, Devendraa;  Pawar, Sunil D.
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/02
Microtops II ozonometer  Total column ozone  Precipitable water content  Aerosol optical depth  
A preliminary study on wind tunnel simulations of the explosive growth and dissipation of fine particulate matter in ambient air 期刊论文
ATMOSPHERIC RESEARCH, 2020, 235
作者:  Xu, Jingxin;  Zhu, Fahua;  Wang, Sheng;  Zhao, Xiuyong;  Zhang, Ming;  Ge, Xinlei;  Wang, Junfeng;  Tian, Wenxin;  Wang, Liwen;  Yang, Liu;  Ding, Li;  Lu, Xiaobo;  Chen, Xinxin;  Zheng, Youfei;  Guo, Zhaobing
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/02
Wind tunnel  Fine particulate matter  Explosive growth  Dissipation  Relative humidity  Liquid water content  
A cold, massive, rotating disk galaxy 1.5 billion years after the Big Bang 期刊论文
NATURE, 2020, 581 (7808) : 269-+
作者:  Poplawski, Gunnar H. D.;  Kawaguchi, Riki;  Van Niekerk, Erna;  Lu, Paul;  Mehta, Neil;  Canete, Philip;  Lie, Richard;  Dragatsis, Ioannis;  Meves, Jessica M.;  Zheng, Binhai;  Coppola, Giovanni;  Tuszynski, Mark H.
收藏  |  浏览/下载:91/0  |  提交时间:2020/07/03

Massive disk galaxies like the Milky Way are expected to form at late times in traditional models of galaxy formation(1,2), but recent numerical simulations suggest that such galaxies could form as early as a billion years after the Big Bang through the accretion of cold material and mergers(3,4). Observationally, it has been difficult to identify disk galaxies in emission at high redshift(5,6) in order to discern between competing models of galaxy formation. Here we report imaging, with a resolution of about 1.3 kiloparsecs, of the 158-micrometre emission line from singly ionized carbon, the far-infrared dust continuum and the near-ultraviolet continuum emission from a galaxy at a redshift of 4.2603, identified by detecting its absorption of quasar light. These observations show that the emission arises from gas inside a cold, dusty, rotating disk with a rotational velocity of about 272 kilometres per second. The detection of emission from carbon monoxide in the galaxy yields a molecular mass that is consistent with the estimate from the ionized carbon emission of about 72 billion solar masses. The existence of such a massive, rotationally supported, cold disk galaxy when the Universe was only 1.5 billion years old favours formation through either cold-mode accretion or mergers, although its large rotational velocity and large content of cold gas remain challenging to reproduce with most numerical simulations(7,8).


A massive rotating disk galaxy was formed a mere 1.5 billion years after the Big Bang, a surprisingly short time after the origin of the Universe.


  
An acute immune response underlies the benefit of cardiac stem cell therapy 期刊论文
NATURE, 2020, 577 (7790) : 405-+
作者:  Schmacke, Niklas A.;  Hornung, Veit
收藏  |  浏览/下载:48/0  |  提交时间:2020/07/03

Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this day(1,2), despite ongoing questions of efficacy and a lack of mechanistic understanding of the underlying biological effect(3). The rationale for these cell therapy trials is derived from animal studies that show a modest but reproducible improvement in cardiac function in models of cardiac ischaemic injury(4,5). Here we examine the mechanistic basis for cell therapy in mice after ischaemia-reperfusion injury, and find that-although heart function is enhanced-it is not associated with the production of new cardiomyocytes. Cell therapy improved heart function through an acute sterile immune response characterized by the temporal and regional induction of CCR2(+) and CX3CR1(+) macrophages. Intracardiac injection of two distinct types of adult stem cells, cells killed by freezing and thawing or a chemical inducer of the innate immune response all induced a similar regional accumulation of CCR2(+) and CX3CR1(+) macrophages, and provided functional rejuvenation to the heart after ischaemia-reperfusion injury. This selective macrophage response altered the activity of cardiac fibroblasts, reduced the extracellular matrix content in the border zone and enhanced the mechanical properties of the injured area. The functional benefit of cardiac cell therapy is thus due to an acute inflammatory-based wound-healing response that rejuvenates the infarcted area of the heart.


  
What Caused the Large-Scale Heat Deficit in the Subtropical South Atlantic Ocean During 2009-2012? 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (11)
作者:  Dong, Shenfu;  Lopez, Hosmay;  Lee, Sang-Ki;  Meinen, Christopher S.;  Goni, Gustavo;  Baringer, Molly
收藏  |  浏览/下载:32/0  |  提交时间:2020/05/13
South Atlantic  ocean heat content changes  ocean heat transport  central tropical Pacific cooling  Pacific-South American mode 2  Southern Annular Mode  
Quantifying the Controls on Evapotranspiration Partitioning in the Highest Alpine Meadow Ecosystem 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (4)
作者:  Cui, Jiangpeng;  Tian, Lide;  Wei, Zhongwang;  Huntingford, Chris;  Wang, Pei;  Cai, Zhongyin;  Ma, Ning;  Wang, Lixin
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/02
chamber  evapotranspiration partitioning  leaf area index  soil water content  stable isotopes  Tibetan Plateau  
Sialylation of immunoglobulin E is a determinant of allergic pathogenicity 期刊论文
NATURE, 2020, 582 (7811) : 265-+
作者:  Abdul-Masih, Michael;  Banyard, Gareth;  Bodensteiner, Julia;  Bordier, Emma;  Bowman, Dominic M.;  Dsilva, Karan;  Fabry, Matthias;  Hawcroft, Calum;  Mahy, Laurent;  Marchant, Pablo;  Raskin, Gert;  Reggiani, Maddalena;  Shenar, Tomer;  Tkachenko, Andrew;  Van Winckel, Hans;  Vermeylen, Lore;  Sana, Hugues
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/03

A specific type of glycosylation-sialylation-is more common on immunoglobulin E from individuals with a peanut allergys than from non-atopic people, suggesting that it has a role in regulating anaphylaxis.


Approximately one-third of the world'  s population suffers from allergies(1). Exposure to allergens crosslinks immunoglobulin E (IgE) antibodies that are bound to mast cells and basophils, triggering the release of inflammatory mediators, including histamine(2). Although IgE is absolutely required for allergies, it is not understood why total and allergen-specific IgE concentrations do not reproducibly correlate with allergic disease(3-5). It is well-established that glycosylation of IgG dictates its effector function and has disease-specific patterns. However, whether IgE glycans differ in disease states or affect biological activity is completely unknown(6). Here we perform an unbiased examination of glycosylation patterns of total IgE from individuals with a peanut allergy and from non-atopic individuals without allergies. Our analysis reveals an increase in sialic acid content on total IgE from individuals with a peanut allergy compared with non-atopic individuals. Removal of sialic acid from IgE attenuates effector-cell degranulation and anaphylaxis in several functional models of allergic disease. Therapeutic interventions-including removing sialic acid from cell-bound IgE with a neuraminidase enzyme targeted towards the IgE receptor Fc epsilon RI, and administering asialylated IgE-markedly reduce anaphylaxis. Together, these results establish IgE glycosylation, and specifically sialylation, as an important regulator of allergic disease.