GSTDTAP

浏览/检索结果: 共3条,第1-3条 帮助

已选(0)清除 条数/页:   排序方式:
A reference map of the human binary protein interactome 期刊论文
NATURE, 2020, 580 (7803) : 402-+
作者:  Fan, Chen;  Sukomon, Nattakan;  Flood, Emelie;  Rheinberger, Jan;  Allen, Toby W.;  Nimigean, Crina M.
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03

Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships(1,2). Here we present a human '  all-by-all'  reference interactome map of human binary protein interactions, or '  HuRI'  . With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome(3), transcriptome(4) and proteome(5) data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.


  
The neotropical reforestation hotspots: A biophysical and socioeconomic typology of contemporary forest expansion 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2019, 54: 148-159
作者:  Sofia Nanni, A.;  Sloan, Sean;  Mitchell Aide, T.;  Graesser, Jordan;  Edwards, David;  Ricardo Grau, H.
收藏  |  浏览/下载:29/0  |  提交时间:2019/04/09
Reforestation  Latin America and the Caribbean  Hotspots  Regional contexts  
The Development of Industrial Symbiosis in Existing Contexts. Experiences From Three Italian Clusters 期刊论文
ECOLOGICAL ECONOMICS, 2017, 139
作者:  Taddeo, Raffaella;  Simboli, Alberto;  Morgante, Anna;  Erkman, Suren
收藏  |  浏览/下载:21/0  |  提交时间:2019/04/09
Industrial ecology  Industrial symbiosis  Industrial clusters  Contexts  Case Study