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B cells are associated with survival and immunotherapy response in sarcoma 期刊论文
NATURE, 2020, 577 (7791) : 556-+
作者:  Willis, J. P.;  Canning, R. E. A.;  Noordeh, E. S.;  Allen, S. W.;  King, A. L.;  Mantz, A.;  Morris, R. G.;  Stanford, S. A.;  Brammer, G.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/03

Soft-tissue sarcomas represent a heterogeneous group of cancer, with more than 50 histological subtypes(1,2). The clinical presentation of patients with different subtypes is often atypical, and responses to therapies such as immune checkpoint blockade vary widely(3,4). To explain this clinical variability, here we study gene expression profiles in 608 tumours across subtypes of soft-tissue sarcoma. We establish an immune-based classification on the basis of the composition of the tumour microenvironment and identify five distinct phenotypes: immune-low (A and B), immune-high (D and E), and highly vascularized (C) groups. In situ analysis of an independent validation cohort shows that class E was characterized by the presence of tertiary lymphoid structures that contain T cells and follicular dendritic cells and are particularly rich in B cells. B cells are the strongest prognostic factor even in the context of high or low CD8(+) T cells and cytotoxic contents. The class-E group demonstrated improved survival and a high response rate to PD1 blockade with pembrolizumab in a phase 2 clinical trial. Together, this work confirms the immune subtypes in patients with soft-tissue sarcoma, and unravels the potential of B-cell-rich tertiary lymphoid structures to guide clinical decision-making and treatments, which could have broader applications in other diseases.


Immune profiling of the tumour microenvironment of soft-tissue sarcoma identifies a group of patients with high levels of B-cell infiltration and tertiary lymphoid structures that have improved survival and a high response rate to immune checkpoint blockade therapy.


  
When can decision analysis improve climate adaptation planning? Two procedures to match analysis approaches with adaptation problems 期刊论文
CLIMATIC CHANGE, 2019, 157 (3-4) : 611-630
作者:  Shi, Rui;  Hobbs, Benjamin F.;  Jiang, Huai
收藏  |  浏览/下载:22/0  |  提交时间:2020/02/17
Climate change adaptation  Type of decision analysis  Cost-benefit analysis  Climate uncertainty  Chesapeake Bay  
A cost-benefit analysis of climate-smart agriculture options in Southern Africa: Balancing gender and technology 期刊论文
ECOLOGICAL ECONOMICS, 2019, 163: 126-137
作者:  Mutenje, Munyaradzi Junia;  Farnworth, Cathy Rozel;  Stirling, Clare;  Thierfelder, Christian;  Mupangwa, Walter;  Nyagumbo, Isaiah
收藏  |  浏览/下载:25/0  |  提交时间:2019/11/27
Gender  Intra-household decision-making  Climate-smart agriculture  Cost-benefit analysis  Southern Africa  
Participatory multi-criteria decision analysis in valuing peatland ecosystem services-Trade-offs related to peat extraction vs. pristine peatlands in Southern Finland 期刊论文
ECOLOGICAL ECONOMICS, 2019, 162: 17-28
作者:  Heli, Saarikoski;  Jyri, Mustajoki;  Turo, Hjerppe;  Kaisu, Aapala
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Ecosystem services  Valuation  Participatory multi-criteria decision analysis  Social values  Peatlands  
Examining pedestrian satisfaction in gated and open communities: An integration of gradient boosting decision trees and impact-asymmetry analysis 期刊论文
LANDSCAPE AND URBAN PLANNING, 2019, 185: 246-257
作者:  Dong, Wei;  Cao, Xinyu;  Wu, Xinyi;  Dong, Yu
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/26
Importance performance analysis  Satisfaction  Walkability  Decision tree  Neighborhood design  
Allocating CO2 allowances to emitters in China: A multi-objective decision approach 期刊论文
ENERGY POLICY, 2018, 121: 441-451
作者:  Zhu, Bangzhu;  Jiang, Mingxing;  He, Kaijian;  Chevallier, Julien;  Xie, Rui
收藏  |  浏览/下载:31/0  |  提交时间:2019/04/09
China CO2 allowance allocation  Major industries  Multi-objective decision analysis  Fairness  Efficiency  Feasibility  
Ranking CMIP5 GCMs for Model Ensemble Selection on Regional Scale: Case Study of the Indochina Region 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (17) : 8949-8974
作者:  Chhin, Rattana;  Yoden, Shigeo
收藏  |  浏览/下载:14/0  |  提交时间:2019/04/09
performance metric  EOF analysis  culling method  optimal ensemble subsets  decision graph  model-as-truth experiments  
Economically robust protection against 21st century sea-level rise 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2018, 51: 67-73
作者:  Lincke, Daniel;  Hinkel, Jochen
收藏  |  浏览/下载:15/0  |  提交时间:2019/04/09
Sea-level rise impacts  Coastal protection  Robust decision analysis  
Using Contingent Valuation and Numerical Methods to Determine Optimal Locations for Environmental Facilities: Public Arboretums in South Korea 期刊论文
ECOLOGICAL ECONOMICS, 2018, 149: 184-201
作者:  Choi, Hyunhong;  Koo, Yoonmo
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/09
Contingent valuation method  Decision analysis  Location optimization  Nested partitions  
A multi-criteria analysis of coal-based power generation in Bangladesh 期刊论文
ENERGY POLICY, 2018, 116: 182-192
作者:  Zaman, Rafia;  Brudermann, Thomas;  Kumar, S.;  Islam, Nazrul
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
Coal  Energy Security  Energy Transition  Analytical Hierarchy Process  Multi-Criteria Decision Analysis