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Current European flood-rich period exceptional compared with past 500 years 期刊论文
NATURE, 2020, 583 (7817) : 560-+
作者:  ;  nter Blö;  schl;  Andrea Kiss;  Alberto Viglione;  Mariano Barriendos;  Oliver Bö;  hm;  Rudolf Brá;  zdil;  Denis Coeur;  Gaston Demaré;  e;  Maria Carmen Llasat;  Neil Macdonald;  Dag Retsö;  Lars Roald;  Petra Schmocker-Fackel;  Inê;  s Amorim;  Monika Bě;  ;  nová;  Gerardo Benito;  Chiara Bertolin;  Dario Camuffo;  Daniel Cornel;  Radosł;  aw Doktor;  ;  bor Elleder;  Silvia Enzi;  Joã;  o Carlos Garcia;  ;  diger Glaser;  Julia Hall;  Klaus Haslinger;  Michael Hofstä;  tter;  ;  rgen Komma;  Danuta Limanó;  wka;  David Lun;  Andrei Panin;  Juraj Parajka;  Hrvoje Petrić;  Fernando S. Rodrigo;  Christian Rohr;  Johannes Schö;  nbein;  Lothar Schulte;  Luí;  s Pedro Silva;  Willem H. J. Toonen;  Peter Valent;  ;  rgen Waser;  Oliver Wetter
收藏  |  浏览/下载:80/0  |  提交时间:2020/08/09

There are concerns that recent climate change is altering the frequency and magnitude of river floods in an unprecedented way(1). Historical studies have identified flood-rich periods in the past half millennium in various regions of Europe(2). However, because of the low temporal resolution of existing datasets and the relatively low number of series, it has remained unclear whether Europe is currently in a flood-rich period from a long-term perspective. Here we analyse how recent decades compare with the flood history of Europe, using a new database composed of more than 100 high-resolution (sub-annual) historical flood series based on documentary evidence covering all major regions of Europe. We show that the past three decades were among the most flood-rich periods in Europe in the past 500 years, and that this period differs from other flood-rich periods in terms of its extent, air temperatures and flood seasonality. We identified nine flood-rich periods and associated regions. Among the periods richest in floods are 1560-1580 (western and central Europe), 1760-1800 (most of Europe), 1840-1870 (western and southern Europe) and 1990-2016 (western and central Europe). In most parts of Europe, previous flood-rich periods occurred during cooler-than-usual phases, but the current flood-rich period has been much warmer. Flood seasonality is also more pronounced in the recent period. For example, during previous flood and interflood periods, 41 per cent and 42 per cent of central European floods occurred in summer, respectively, compared with 55 per cent of floods in the recent period. The exceptional nature of the present-day flood-rich period calls for process-based tools for flood-risk assessment that capture the physical mechanisms involved, and management strategies that can incorporate the recent changes in risk.


Analysis of thousands of historical documents recording floods in Europe shows that flooding characteristics in recent decades are unlike those of previous centuries.


  
The proteome landscape of the kingdoms of life 期刊论文
NATURE, 2020
作者:  Arzi, Anat;  Rozenkrantz, Liron;  Gorodisky, Lior;  Rozenkrantz, Danit;  Holtzman, Yael;  Ravia, Aharon;  Bekinschtein, Tristan A.;  Galperin, Tatyana;  Krimchansky, Ben-Zion;  Cohen, Gal;  Oksamitni, Anna;  Aidinoff, Elena;  Sacher, Yaron;  Sobel, Noam
收藏  |  浏览/下载:42/0  |  提交时间:2020/07/03

Proteins carry out the vast majority of functions in all biological domains, but for technological reasons their large-scale investigation has lagged behind the study of genomes. Since the first essentially complete eukaryotic proteome was reported(1), advances in mass-spectrometry-based proteomics(2)have enabled increasingly comprehensive identification and quantification of the human proteome(3-6). However, there have been few comparisons across species(7,8), in stark contrast with genomics initiatives(9). Here we use an advanced proteomics workflow-in which the peptide separation step is performed by a microstructured and extremely reproducible chromatographic system-for the in-depth study of 100 taxonomically diverse organisms. With two million peptide and 340,000 stringent protein identifications obtained in a standardized manner, we double the number of proteins with solid experimental evidence known to the scientific community. The data also provide a large-scale case study for sequence-based machine learning, as we demonstrate by experimentally confirming the predicted properties of peptides fromBacteroides uniformis. Our results offer a comparative view of the functional organization of organisms across the entire evolutionary range. A remarkably high fraction of the total proteome mass in all kingdoms is dedicated to protein homeostasis and folding, highlighting the biological challenge of maintaining protein structure in all branches of life. Likewise, a universally high fraction is involved in supplying energy resources, although these pathways range from photosynthesis through iron sulfur metabolism to carbohydrate metabolism. Generally, however, proteins and proteomes are remarkably diverse between organisms, and they can readily be explored and functionally compared at www.proteomesoflife.org.


  
A distributional code for value in dopamine-based reinforcement learning 期刊论文
NATURE, 2020, 577 (7792) : 671-+
作者:  House, Robert A.;  Maitra, Urmimala;  Perez-Osorio, Miguel A.;  Lozano, Juan G.;  Jin, Liyu;  Somerville, James W.;  Duda, Laurent C.;  Nag, Abhishek;  Walters, Andrew;  Zhou, Ke-Jin;  Roberts, Matthew R.;  Bruce, Peter G.
收藏  |  浏览/下载:77/0  |  提交时间:2020/07/03

Since its introduction, the reward prediction error theory of dopamine has explained a wealth of empirical phenomena, providing a unifying framework for understanding the representation of reward and value in the brain(1-3). According to the now canonical theory, reward predictions are represented as a single scalar quantity, which supports learning about the expectation, or mean, of stochastic outcomes. Here we propose an account of dopamine-based reinforcement learning inspired by recent artificial intelligence research on distributional reinforcement learning(4-6). We hypothesized that the brain represents possible future rewards not as a single mean, but instead as a probability distribution, effectively representing multiple future outcomes simultaneously and in parallel. This idea implies a set of empirical predictions, which we tested using single-unit recordings from mouse ventral tegmental area. Our findings provide strong evidence for a neural realization of distributional reinforcement learning.


Analyses of single-cell recordings from mouse ventral tegmental area are consistent with a model of reinforcement learning in which the brain represents possible future rewards not as a single mean of stochastic outcomes, as in the canonical model, but instead as a probability distribution.


  
Quantifying the impact of changing the threshold of New York City heat emergency plan in reducing heat-related illnesses 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (11)
作者:  Benmarhnia, Tarik;  Schwarz, Lara;  Nori-Sarma, Amruta;  Bell, Michelle L.
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
heat action plans  heat related illnesses  quasi-experimental designs  evidence based policy  climate change  
How to evaluate a monitoring system for adaptive policies: criteria for signposts selection and their model-based evaluation 期刊论文
CLIMATIC CHANGE, 2019, 153: 267-283
作者:  Raso, Luciano;  Kwakkel, Jan;  Timmermans, Jos;  Panthou, Geremy
收藏  |  浏览/下载:29/0  |  提交时间:2019/11/26
Monitoring  Climate change  Adaptive policies  Dynamic adaptive policy pathways  Signposts  Evidence based  Monitoring  Information  Flood management  Extremes  Deep uncertainty  Niger River  
The tragedy of the science-policy gap - Revised legislation fails to protect an endangered species in a managed boreal landscape 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 422: 172-178
作者:  Wistbacka, Ralf;  Orell, Markku;  Santangeli, Andrea
收藏  |  浏览/下载:33/0  |  提交时间:2019/04/09
Science-policy interface  Evidence-based conservation  Conservation effectiveness  Environmental legislation  Decision making  Conservation policy  Forest management  Forestry legislation  Species conservation  Conservation evidence  
Quality of Care for PTSD and Depression in the Military Health System: Phase I Report 科技报告
来源:Rand Corporation. 出版年: 2016
作者:  Kimberly A. Hepner;  Elizabeth M. Sloss;  Carol P. Roth;  Heather Krull;  Susan M. Paddock;  Shaela Moen;  Martha J. Timmer;  Harold Alan Pincus
收藏  |  浏览/下载:42/0  |  提交时间:2019/04/05
Military Health and Health Care  Depression  Health Care Quality Measurement  Evidence Based Health Practice  Post-Traumatic Stress Disorder  Mental Health Treatment  
Improving Population Health Through an Innovative Collaborative: The Be There San Diego Data for Quality Group 科技报告
来源:Rand Corporation. 出版年: 2016
作者:  Allen Fremont;  Ashley Kranz;  Jessica Phillips;  Chandra Garber
收藏  |  浏览/下载:20/0  |  提交时间:2019/04/05
Diabetes  Evidence Based Health Practice  Health Care Quality  Community Health  Hypertension  San Diego  
Agreement with, and feasibility of, the emerging recommendations from the Living with Breathlessness study: Findings from an online stakeholder survey 科技报告
来源:Rand Corporation. 出版年: 2016
作者:  Catherine L. Saunders;  Peter Burge;  Morag Farquhar;  Sarah Grand-Clement;  Susan Guthrie;  Tom Ling
收藏  |  浏览/下载:15/0  |  提交时间:2019/04/05
Health Care Delivery Approaches  Evidence Based Health Practice  Primary Care  Chronic Obstructive Pulmonary Disease  Patient Experience  End of Life Care  
Integrative Review of Decentralized and Local Water Management Concepts as Part of Smart Cities (LoWaSmart) 科技报告
来源:Center for International Climate and Environmental Research-Oslo (CICERO). 出版年: 2016
作者:  Umar, Muhammad;  Uhl, Wolfgang
收藏  |  浏览/下载:19/0  |  提交时间:2019/04/05
VDP::Matematikk og naturvitenskap: 400  VDP::Mathematics and natural scienses: 400  Desentral vannforvaltning / Decentralized Water Management  Evidensbasert kunnskapsoppsummering / Evidence based reviews  Lokal vannforvaltning / Local Water Management  Smarte Byer / Smart Cities