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A reference map of the human binary protein interactome 期刊论文
NATURE, 2020, 580 (7803) : 402-+
作者:  Fan, Chen;  Sukomon, Nattakan;  Flood, Emelie;  Rheinberger, Jan;  Allen, Toby W.;  Nimigean, Crina M.
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/03

Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships(1,2). Here we present a human '  all-by-all'  reference interactome map of human binary protein interactions, or '  HuRI'  . With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome(3), transcriptome(4) and proteome(5) data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.


  
Role of host genetics and heat-tolerant algal symbionts in sustaining populations of the endangered coral Orbicella faveolata in the Florida Keys with ocean warming 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (3) : 1016-1031
作者:  Manzello, Derek P.;  Matz, Mikhail, V;  Enochs, Ian C.;  Valentino, Lauren;  Carlton, Renee D.;  Kolodziej, Graham;  Serrano, Xaymara;  Towle, Erica K.;  Jankulak, Mike
收藏  |  浏览/下载：10/0  |  提交时间：2019/04/09
2bRAD  climate change  coral host genotype  Durusdinium trenchii  qPCR  Symbiodinium  
Tolerance traits related to climate change resilience are independent and polygenic 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (11) : 5348-5360
作者:  Healy, Timothy M.;  Brennan, Reid S.;  Whitehead, Andrew;  Schulte, Patricia M.
收藏  |  浏览/下载：14/0  |  提交时间：2019/04/09
association  genotype-phenotype  hypoxia tolerance  oxygen  temperature  thermal tolerance  
A common garden experiment examining light use efficiency and heat sum to explain growth differences in native and exotic Pinus taeda 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 425: 35-44
作者:  Albaugh, Timothy J.;  Fox, Thomas R.;  Maier, Chris A.;  Campoe, Otavio C.;  Rubilar, Rafael A.;  Cook, Rachel L.;  Raymond, Jay E.;  Alvares, Clayton A.;  Stape, Jose L.
收藏  |  浏览/下载：14/0  |  提交时间：2019/04/09
Absorbed light  Density  Genotype  Natural range  Vapor pressure deficit  
Ecotypic variation and stability in growth performance of the thermophilic conifer Pinus halepensis across the Mediterranean basin 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 424: 205-215
作者:  Voltas, Jordi;  Shestakova, Tatiana A.;  Patsiou, Theofania;  di Matteo, Giovanni;  Klein, Tamir
收藏  |  浏览/下载：17/0  |  提交时间：2019/04/09
Adaptive responses  Aleppo pine  Genotype-by-environment interaction  Phenotypic plasticity  Mixed models  Stability analysis  
Community-based biotic effects as determinants of tree resistance to pests and pathogens 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 417: 301-312
作者:  Iason, Glenn R.;  Taylor, Joanne;  Helfer, Stephan
收藏  |  浏览/下载：17/0  |  提交时间：2019/04/09
Associational resistance  Induced resistance  Hybridisation  Endophytes  Mycorrhiza  Host genotype  
Role of population genetics in guiding ecological responses to climate 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (2) : 858-868
作者:  Rehfeldt, Gerald E.;  Leites, Laura P.;  Joyce, Dennis G.;  Weiskittel, Aaron R.
收藏  |  浏览/下载：10/0  |  提交时间：2019/04/09
climate change responses  ecological genetics  ecological optimum  genetic differentiation  genotype-environment interactions  growth potential-cold hardiness tradeoff  physiological optimum  
Will phenotypic plasticity affecting flowering phenology keep pace with climate change? 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (6)
作者:  Richardson, Bryce A.;  Chaney, Lindsay;  Shaw, Nancy L.;  Still, Shannon M.
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/09
Artemisia tridentata  common garden  genotype-environment interaction  mixed-effects model  photoperiod  range shifts