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Exploring dynamical phase transitions with cold atoms in an optical cavity 期刊论文
NATURE, 2020, 580 (7805) : 602-+
作者:  Halbach, Rebecca;  Miesen, Pascal;  Joosten, Joep;  Taskopru, Ezgi;  Rondeel, Inge;  Pennings, Bas;  Vogels, Chantal B. F.;  Merkling, Sarah H.;  Koenraadt, Constantianus J.;  Lambrechts, Louis;  van Rij, Ronald P.
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/03

Interactions between light and an ensemble of strontium atoms in an optical cavity can serve as a testbed for studying dynamical phase transitions, which are currently not well understood.


Interactions between atoms and light in optical cavities provide a means of investigating collective (many-body) quantum physics in controlled environments. Such ensembles of atoms in cavities have been proposed for studying collective quantum spin models, where the atomic internal levels mimic a spin degree of freedom and interact through long-range interactions tunable by changing the cavity parameters(1-4). Non-classical steady-state phases arising from the interplay between atom-light interactions and dissipation of light from the cavity have previously been investigated(5-11). These systems also offer the opportunity to study dynamical phases of matter that are precluded from existence at equilibrium but can be stabilized by driving a system out of equilibrium(12-16), as demonstrated by recent experiments(17-22). These phases can also display universal behaviours akin to standard equilibrium phase transitions(8,23,24). Here, we use an ensemble of about a million strontium-88 atoms in an optical cavity to simulate a collective Lipkin-Meshkov-Glick model(25,26), an iconic model in quantum magnetism, and report the observation of distinct dynamical phases of matter in this system. Our system allows us to probe the dependence of dynamical phase transitions on system size, initial state and other parameters. These observations can be linked to similar dynamical phases in related systems, including the Josephson effect in superfluid helium(27), or coupled atomic(28) and solid-state polariton(29) condensates. The system itself offers potential for generation of metrologically useful entangled states in optical transitions, which could permit quantum enhancement in state-of-the-art atomic clocks(30,31).


  
Gut stem cell necroptosis by genome instability triggers bowel inflammation 期刊论文
NATURE, 2020, 580 (7803) : 386-+
作者:  Xing, Lida;  39;Connor, Jingmai K.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

The aetiology of inflammatory bowel disease (IBD) is a multifactorial interplay between heredity and environment(1,2). Here we report that deficiency in SETDB1, a histone methyltransferase that mediates the trimethylation of histone H3 at lysine 9, participates in the pathogenesis of IBD. We found that levels of SETDB1 are decreased in patients with IBD, and that mice with reduced SETDB1 in intestinal stem cells developed spontaneous terminal ileitis and colitis. SETDB1 safeguards genome stability(3), and the loss of SETDB1 in intestinal stem cells released repression of endogenous retroviruses (retrovirus-like elements with long repeats that, in humans, comprise approximately 8% of the genome). Excessive viral mimicry generated by motivated endogenous retroviruses triggered Z-DNA-binding protein 1 (ZBP1)-dependent necroptosis, which irreversibly disrupted homeostasis of the epithelial barrier and promoted bowel inflammation. Genome instability, reactive endogenous retroviruses, upregulation of ZBP1 and necroptosis were all seen in patients with IBD. Pharmaceutical inhibition of RIP3 showed a curative effect in SETDB1-deficient mice, which suggests that targeting necroptosis of intestinal stem cells may represent an approach for the treatment of severe IBD.


  
The relationship between research and education: typologies and indicators. A literature review 科技报告
来源:Center for International Climate and Environmental Research-Oslo (CICERO). 出版年: 2016
作者:  Elken, Mari;  Wollscheid, Sabine
收藏  |  浏览/下载:17/0  |  提交时间:2019/04/05
Literature review  Interplay  Research and education  Linkage