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Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping 期刊论文
NATURE, 2020, 583 (7817) : 638-+
作者:  Lin, Yiheng;  Leibrandt, David R.;  Leibfriedz, Dietrich;  Chou, Chin-wen
收藏  |  浏览/下载:44/0  |  提交时间:2020/07/03

A method termed ac(4)C-seq is introduced for the transcriptome-wide mapping of the RNA modificationN(4)-acetylcytidine, revealing widespread temperature-dependent acetylation that facilitates thermoadaptation in hyperthermophilic archaea.


N-4-acetylcytidine (ac(4)C) is an ancient and highly conserved RNA modification that is present on tRNA and rRNA and has recently been investigated in eukaryotic mRNA(1-3). However, the distribution, dynamics and functions of cytidine acetylation have yet to be fully elucidated. Here we report ac(4)C-seq, a chemical genomic method for the transcriptome-wide quantitative mapping of ac(4)C at single-nucleotide resolution. In human and yeast mRNAs, ac(4)C sites are not detected but can be induced-at a conserved sequence motif-via the ectopic overexpression of eukaryotic acetyltransferase complexes. By contrast, cross-evolutionary profiling revealed unprecedented levels of ac(4)C across hundreds of residues in rRNA, tRNA, non-coding RNA and mRNA from hyperthermophilic archaea. (AcC)-C-4 is markedly induced in response to increases in temperature, and acetyltransferase-deficient archaeal strains exhibit temperature-dependent growth defects. Visualization of wild-type and acetyltransferase-deficient archaeal ribosomes by cryo-electron microscopy provided structural insights into the temperature-dependent distribution of ac(4)C and its potential thermoadaptive role. Our studies quantitatively define the ac(4)C landscape, providing a technical and conceptual foundation for elucidating the role of this modification in biology and disease(4-6).


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:41/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Above-ground carbon stock in merchantable trees not reduced between cycles of spruce budworm outbreaks due to changing species composition in spruce-fir forests of Maine, USA 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 453
作者:  Chen, Cen;  Wei, Xinyuan;  Weiskittel, Aaron;  Hayes, Daniel J.
收藏  |  浏览/下载:20/0  |  提交时间:2020/02/17
Red/black/white spruce  Balsam fir  Spruce budworm  Defoliation  Disturbance  Forest Vegetation Simulator  Forest carbon dynamics  Landscape analysis  Individual-based modeling  
Family forest owners and landscape-scale interactions: A review 期刊论文
LANDSCAPE AND URBAN PLANNING, 2019, 188: 4-18
作者:  Mayer, Audrey L.
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Nonindustrial private forest owner  Smallholder  Landscape dynamics  Land management  Forest policy  Landscape planning  
Evolutionarily stable communities: a framework for understanding the role of trait evolution in the maintenance of diversity 期刊论文
ECOLOGY LETTERS, 2018, 21 (12) : 1853-1868
作者:  Edwards, Kyle F.;  Kremer, Colin T.;  Miller, Elizabeth T.;  Osmond, Matthew M.;  Litchman, Elena;  Klausmeier, Christopher A.
收藏  |  浏览/下载:19/0  |  提交时间:2019/04/09
Adaptive dynamics  adaptive landscape  character displacement  coexistence  eco-evolutionary dynamics  ecological equivalence  ESS  
Groundwater similarity across a watershed derived from time-warped and flow-corrected time series 期刊论文
WATER RESOURCES RESEARCH, 2017, 53 (5)
作者:  Rinderer, M.;  McGlynn, B. L.;  van Meerveld, H. J.
收藏  |  浏览/下载:17/0  |  提交时间:2019/04/09
groundwater dynamics  landscape position  topography  hydrological similarity  Dynamic Time Warping  flow-corrected time transformation  time series  hydrological connectivity  
The historical disturbance regime of mountain Norway spruce forests in the Western Carpathians and its influence on current forest structure and composition 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2017, 388
作者:  Janda, Pavel;  Trotsiuk, Volodymyr;  Mikolas, Martin;  Bace, Radek;  Nagel, Thomas A.;  Seidl, Rupert;  Seedre, Meelis;  Morrissey, Robert C.;  Kucbel, Stanislay.;  Jaloviar, Peter;  Jasik, Marian;  Vysoky, Juraj;  Samonil, Pavel;  Cada, Vojtech;  Mrhalova, Hana;  Labusova, Jana;  Novakova, Marketa H.;  Rydval, Milos;  Mateju, Lenka;  Svoboda, Miroslav
收藏  |  浏览/下载:37/0  |  提交时间:2019/04/09
Dendroecology  Forest dynamics  Landscape ecology  Disturbance synchronization  Stand structure  Spatio-temporal pattern