GSTDTAP

浏览/检索结果: 共166条,第1-10条 帮助

已选(0)清除 条数/页:   排序方式:
南极变暖速度达全球平均水平3倍多的主因是自然因素 快报文章
气候变化快报,2020年第14期
作者:  董利苹,薛明媚
Microsoft Word(13Kb)  |  收藏  |  浏览/下载:375/0  |  提交时间:2020/07/20
South Pole  Record Warming  Southern Annular Mode  
Global Model of Whistler Mode Chorus in the Near-Equatorial Region (|lambda(m)|< 18 degrees) 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (11)
作者:  Meredith, Nigel P.;  Horne, Richard B.;  Shen, Xiao-Chen;  Li, Wen;  Bortnik, Jacob
收藏  |  浏览/下载:10/0  |  提交时间:2020/05/25
whistler mode chorus  wave-particle interactions  radiation belts  
Surface Ocean Warming Around Australia Driven by Interannual Variability and Long-Term Trends in Southern Hemisphere Westerlies 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (9)
作者:  Duran, E. R.;  England, M. H.;  Spence, P.
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Tasman Sea  South Australian Basin  Ocean surface warming  Southern Annular Mode  interannual wind variability  Twenty first Century projections  
"Warm Arctic-Cold Siberia" as an Internal Mode Instigated by North Atlantic Warming 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (9)
作者:  Jin, Chunhan;  Wang, Bin;  Yang, Young-Min;  Liu, Jian
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/02
"Warm Arctic-Cold Siberia" pattern  AMO  multi-decadal variations  internal mode of variability  Asian winter monsoon  greenhouse gases forcing  
高清晰度模式模拟将大幅改善云和降水的表达 快报文章
地球科学快报,2020年第9期
作者:  刘燕飞
Microsoft Word(13Kb)  |  收藏  |  浏览/下载:374/0  |  提交时间:2020/05/09
cloud  precipitation  high definition mode  climate simulation  
Tropical Pacific cold tongue mode triggered by enhanced warm pool convection due to global warming 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (5)
作者:  Jiang, Ning;  Zhu, Congwen
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/02
cold tongue mode  stepwise response  global warming  tropical Pacific  
HBO1 is required for the maintenance of leukaemia stem cells 期刊论文
NATURE, 2020, 577 (7789) : 266-+
作者:  MacPherson, Laura;  Anokye, Juliana;  Yeung, Miriam M.;  Lam, Enid Y. N.;  Chan, Yih-Chih;  Weng, Chen-Fang;  Yeh, Paul;  Knezevic, Kathy;  Butler, Miriam S.;  Hoegl, Annabelle;  Chan, Kah-Lok;  Burr, Marian L.;  Gearing, Linden J.;  Willson, Tracy;  Liu, Joy;  Choi, Jarny;  Yang, Yuqing;  Bilardi, Rebecca A.;  Falk, Hendrik;  Nghi Nguyen;  Stupple, Paul A.;  Peat, Thomas S.;  Zhang, Ming;  de Silva, Melanie;  Carrasco-Pozo, Catalina;  Avery, Vicky M.;  Khoo, Poh Sim;  Dolezal, Olan;  Dennis, Matthew L.;  Nuttall, Stewart;  Surjadi, Regina;  Newman, Janet;  Ren, Bin;  Leaver, David J.;  Sun, Yuxin;  Baell, Jonathan B.;  Dovey, Oliver;  Vassiliou, George S.;  Grebien, Florian;  Dawson, Sarah-Jane;  Street, Ian P.;  Monahan, Brendon J.;  Burns, Christopher J.;  Choudhary, Chunaram;  Blewitt, Marnie E.;  Voss, Anne K.;  Thomas, Tim;  Dawson, Mark A.
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/03

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks of AML have progressed into clinical trials, but most show only modest efficacy owing to an inability to effectively eradicate leukaemia stem cells (LSCs)(1). Here, to specifically identify novel dependencies in LSCs, we screened a bespoke library of small hairpin RNAs that target chromatin regulators in a unique ex vivo mouse model of LSCs. We identify the MYST acetyltransferase HBO1 (also known as KAT7 or MYST2) and several known members of the HBO1 protein complex as critical regulators of LSC maintenance. Using CRISPR domain screening and quantitative mass spectrometry, we identified the histone acetyltransferase domain of HBO1 as being essential in the acetylation of histone H3 at K14. H3 acetylated at K14 (H3K14ac) facilitates the processivity of RNA polymerase II to maintain the high expression of key genes (including Hoxa9 and Hoxa10) that help to sustain the functional properties of LSCs. To leverage this dependency therapeutically, we developed a highly potent small-molecule inhibitor of HBO1 and demonstrate its mode of activity as a competitive analogue of acetyl-CoA. Inhibition of HBO1 phenocopied our genetic data and showed efficacy in a broad range of human cell lines and primary AML cells from patients. These biological, structural and chemical insights into a therapeutic target in AML will enable the clinical translation of these findings.


  
A cold, massive, rotating disk galaxy 1.5 billion years after the Big Bang 期刊论文
NATURE, 2020, 581 (7808) : 269-+
作者:  Poplawski, Gunnar H. D.;  Kawaguchi, Riki;  Van Niekerk, Erna;  Lu, Paul;  Mehta, Neil;  Canete, Philip;  Lie, Richard;  Dragatsis, Ioannis;  Meves, Jessica M.;  Zheng, Binhai;  Coppola, Giovanni;  Tuszynski, Mark H.
收藏  |  浏览/下载:63/0  |  提交时间:2020/07/03

Massive disk galaxies like the Milky Way are expected to form at late times in traditional models of galaxy formation(1,2), but recent numerical simulations suggest that such galaxies could form as early as a billion years after the Big Bang through the accretion of cold material and mergers(3,4). Observationally, it has been difficult to identify disk galaxies in emission at high redshift(5,6) in order to discern between competing models of galaxy formation. Here we report imaging, with a resolution of about 1.3 kiloparsecs, of the 158-micrometre emission line from singly ionized carbon, the far-infrared dust continuum and the near-ultraviolet continuum emission from a galaxy at a redshift of 4.2603, identified by detecting its absorption of quasar light. These observations show that the emission arises from gas inside a cold, dusty, rotating disk with a rotational velocity of about 272 kilometres per second. The detection of emission from carbon monoxide in the galaxy yields a molecular mass that is consistent with the estimate from the ionized carbon emission of about 72 billion solar masses. The existence of such a massive, rotationally supported, cold disk galaxy when the Universe was only 1.5 billion years old favours formation through either cold-mode accretion or mergers, although its large rotational velocity and large content of cold gas remain challenging to reproduce with most numerical simulations(7,8).


A massive rotating disk galaxy was formed a mere 1.5 billion years after the Big Bang, a surprisingly short time after the origin of the Universe.


  
What Caused the Large-Scale Heat Deficit in the Subtropical South Atlantic Ocean During 2009-2012? 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (11)
作者:  Dong, Shenfu;  Lopez, Hosmay;  Lee, Sang-Ki;  Meinen, Christopher S.;  Goni, Gustavo;  Baringer, Molly
收藏  |  浏览/下载:11/0  |  提交时间:2020/05/13
South Atlantic  ocean heat content changes  ocean heat transport  central tropical Pacific cooling  Pacific-South American mode 2  Southern Annular Mode  
Volumetric Characterization of the South Atlantic Subtropical Mode Water Types 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (8)
作者:  Bernardo, Piero S.;  Sato, Olga T.
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Mode Water  South Atlantic  Heat flux  Formation  Subtropical Mode Water  Formation rate