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Sialylation of immunoglobulin E is a determinant of allergic pathogenicity 期刊论文
NATURE, 2020, 582 (7811) : 265-+
作者:  Abdul-Masih, Michael;  Banyard, Gareth;  Bodensteiner, Julia;  Bordier, Emma;  Bowman, Dominic M.;  Dsilva, Karan;  Fabry, Matthias;  Hawcroft, Calum;  Mahy, Laurent;  Marchant, Pablo;  Raskin, Gert;  Reggiani, Maddalena;  Shenar, Tomer;  Tkachenko, Andrew;  Van Winckel, Hans;  Vermeylen, Lore;  Sana, Hugues
收藏  |  浏览/下载：23/0  |  提交时间：2020/07/03

A specific type of glycosylation-sialylation-is more common on immunoglobulin E from individuals with a peanut allergys than from non-atopic people, suggesting that it has a role in regulating anaphylaxis.


Approximately one-third of the world'  s population suffers from allergies(1). Exposure to allergens crosslinks immunoglobulin E (IgE) antibodies that are bound to mast cells and basophils, triggering the release of inflammatory mediators, including histamine(2). Although IgE is absolutely required for allergies, it is not understood why total and allergen-specific IgE concentrations do not reproducibly correlate with allergic disease(3-5). It is well-established that glycosylation of IgG dictates its effector function and has disease-specific patterns. However, whether IgE glycans differ in disease states or affect biological activity is completely unknown(6). Here we perform an unbiased examination of glycosylation patterns of total IgE from individuals with a peanut allergy and from non-atopic individuals without allergies. Our analysis reveals an increase in sialic acid content on total IgE from individuals with a peanut allergy compared with non-atopic individuals. Removal of sialic acid from IgE attenuates effector-cell degranulation and anaphylaxis in several functional models of allergic disease. Therapeutic interventions-including removing sialic acid from cell-bound IgE with a neuraminidase enzyme targeted towards the IgE receptor Fc epsilon RI, and administering asialylated IgE-markedly reduce anaphylaxis. Together, these results establish IgE glycosylation, and specifically sialylation, as an important regulator of allergic disease.


  
From theory to experiments for testing the proximate mechanisms of mast seeding: an agenda for an experimental ecology 期刊论文
ECOLOGY LETTERS, 2020, 23 (2) : 210-220
作者:  Bogdziewicz, Michal;  Ascoli, Davide;  Hacket-Pain, Andrew;  Koenig, Walter D.;  Pearse, Ian;  Pesendorfer, Mario;  Satake, Akiko;  Thomas, Peter;  Vacchiano, Giorgio;  Wohlgemuth, Thomas;  Tanentzap, Andrew
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/02
experimental framework  mast seeding  masting  plant reproduction  research agenda  
From theory to experiments for testing the proximate mechanisms of mast seeding: an agenda for an experimental ecology 期刊论文
ECOLOGY LETTERS, 2020, 23 (2) : 210-220
作者:  Bogdziewicz, Michal;  Ascoli, Davide;  Hacket-Pain, Andrew;  Koenig, Walter D.;  Pearse, Ian;  Pesendorfer, Mario;  Satake, Akiko;  Thomas, Peter;  Vacchiano, Giorgio;  Wohlgemuth, Thomas;  Tanentzap, Andrew
收藏  |  浏览/下载：29/0  |  提交时间：2020/02/17
experimental framework  mast seeding  masting  plant reproduction  research agenda  
Temporal changes in fruit production between recurrent prescribed burns in pine woodlands of the Ouachita Mountains 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 451
作者:  Wood, Tamara B.;  Comer, Christopher E.;  Perry, Roger W.;  Oswald, Brian P.
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Fire interval  Ouachita Mountains  Prescribed fire  Short-leaf pine  Soft mast production  Fleshy fruit production  
Temperature and masting control Norway spruce growth, but with high individual tree variability 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 438: 142-150
作者:  Hacket-Pain, Andrew;  Ascoli, Davide;  Berretti, Roberta;  Mencuccini, Maurizio;  Motta, Renzo;  Nola, Paola;  Piussi, Pietro;  Ruffinatto, Flavio;  Vacchiano, Giorgio
收藏  |  浏览/下载：18/0  |  提交时间：2019/11/26
Picea abies  Tree ring  Dendrochronology  Mast  Super-producer  Paneveggio  Growth-reproduction trade-off  
The ground plot counting method: A valid and reliable assessment tool for quantifying seed production in temperate oak forests? 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 430: 143-149
作者:  Touzot, Laura;  Bel-Venner, Marie-Claude;  Gamelon, Marlene;  Focardi, Stefano;  Boulanger, Vincent;  Debias, Francois;  Delzon, Sylvain;  Said, Sonia;  Schermer, Eliane;  Baubet, Eric;  Gaillard, Jean-Michel;  Venner, Samuel
收藏  |  浏览/下载：25/0  |  提交时间：2019/04/09
Mast seeding  Oak tree forests  Acorn production  Ground plot  
Tree-ring-based precipitation reconstruction in the source region of Weihe River, northwest China since AD 1810 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2018, 38 (8) : 3421-3431
作者:  Sun, Changfeng;  Liu, Yu;  Song, Huiming;  Mei, Ruochen;  Payomrat, Paramate;  Wang, Lu;  Liu, Ruoshi
收藏  |  浏览/下载：18/0  |  提交时间：2019/04/09
Mt. Shouyang  Picea purpurea Mast  precipitation reconstruction  source region of Weihe River  tree-ring width  
Fuelwood collection depresses the seed -dispersal service provided by rodents 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2017, 406
作者:  Chen, Wenwen;  Zhong, Jie;  Sun, Shucun;  Xie, Zongqiang;  Zhou, Youbing
收藏  |  浏览/下载：15/0  |  提交时间：2019/04/09
Fuelwood collection  Seed dispersal  Plant recruitment  Rodent  Mast seeding  
Rodent-mediated seed dispersal of Juglans mandshurica regulated by gap size and within-gap position in larch plantations: Implication for converting pure larch plantations into larch-walnut mixed forests 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2017, 404
作者:  Wang, Jing;  Yan, Qiaoling;  Yan, Tao;  Song, Yuan;  Sun, Yirong;  Zhu, Jiaojun
收藏  |  浏览/下载：15/0  |  提交时间：2019/04/09
Seed removal rate  Seed dispersal distance  Seed fate  Mast year  Seed rain