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资源环境科技发展态势分析平台
Global S&T Development Trend Analysis Platform of Resources and Environment
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Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease
期刊论文
NATURE, 2020, 577 (7790) : 399-+
作者:
Gate, David
;
Saligrama, Naresha
;
Leventhal, Olivia
;
Yang, Andrew C.
;
Unger, Michael S.
;
Middeldorp, Jinte
;
Chen, Kelly
;
Lehallier, Benoit
;
Channappa, Divya
;
De Los Santos, Mark B.
;
McBride, Alisha
;
Pluvinage, John
;
Elahi, Fanny
;
Tam, Grace Kyin-Ye
;
Kim, Yongha
;
Greicius, Michael
;
Wagner, Anthony D.
;
Aigner, Ludwig
;
Galasko, Douglas R.
;
Davis, Mark M.
;
Wyss-Coray, Tony
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/03
Alzheimer'
s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function(1). However, little is known about the contribution of the adaptive immune response in Alzheimer'
s disease(2). Here, using integrated analyses of multiple cohorts, we identify peripheral and central adaptive immune changes in Alzheimer'
s disease. First, we performed mass cytometry of peripheral blood mononuclear cells and discovered an immune signature of Alzheimer'
s disease that consists of increased numbers of CD8(+) T effector memory CD45RA(+) (T-EMRA) cells. In a second cohort, we found that CD8(+) T-EMRA cells were negatively associated with cognition. Furthermore, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these cells. Notably, by using several strategies of single-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8(+) T-EMRA cells in the cerebrospinal fluid of patients with Alzheimer'
s disease. Finally, we used machine learning, cloning and peptide screens to demonstrate the specificity of clonally expanded TCRs in the cerebrospinal fluid of patients with Alzheimer'
s disease to two separate Epstein-Barr virus antigens. These results reveal an adaptive immune response in the blood and cerebrospinal fluid in Alzheimer'
s disease and provide evidence of clonal, antigen-experienced T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration.
Knowing when knowledge performs its power in ecological economics
期刊论文
ECOLOGICAL ECONOMICS, 2020, 169
作者:
Hukkinen, Janne I.
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  |  
浏览/下载:9/0
  |  
提交时间:2020/07/02
Perfonnativity
Knowledge brokering
Science-policy interaction
Sustainability transitions
Distributed cognition
Second order knowledge
Which group should policies target? Effects of incentive policies and product cognitions for electric vehicle adoption among Chinese consumers
期刊论文
ENERGY POLICY, 2019, 135
作者:
Yang, Shu
;
Cheng, Peng
;
Li, Jun
;
Wang Shanyong
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  |  
浏览/下载:11/0
  |  
提交时间:2020/02/17
Electric vehicles
Policy perception
Product cognition
Adoption intention
Smart is the new sexy: female mountain chickadees increase reproductive investment when mated to males with better spatial cognition
期刊论文
ECOLOGY LETTERS, 2019, 22 (6) : 897-903
作者:
Branch, Carrie L.
;
Pitera, Angela M.
;
Kozlovsky, Dovid Y.
;
Bridge, Eli S.
;
Pravosudov, Vladimir V.
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/11/26
Chickadee
cognition
fitness
food caching
parental investment
reproduction
spatial memory
Teaching climate change in middle schools and high schools: investigating STEM education's deficit model
期刊论文
CLIMATIC CHANGE, 2018, 149: 305-317
作者:
Plutzer, Eric
;
Hannah, A. Lee
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  |  
浏览/下载:11/0
  |  
提交时间:2019/04/09
Climate change
Education
Motivated cognition
Political polarization
Social complexity and kinship in animal societies
期刊论文
ECOLOGY LETTERS, 2018, 21 (8) : 1129-1134
作者:
Lukas, Dieter
;
Clutton-Brock, Tim
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  |  
浏览/下载:5/0
  |  
提交时间:2019/04/09
Behaviour
cognition
competition
cooperation
evolution
kinship
relatedness
social complexity
sociality
The HyPer(sonal) Piano Project : towards a (per)sonal topography of grand piano and electronics [interactive pdf]
科技报告
来源:Center for International Climate and Environmental Research-Oslo (CICERO). 出版年: 2016
作者:
Qvenild, Morten
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  |  
浏览/下载:3/0
  |  
提交时间:2019/04/05
hyperinstrument
piano
interagency
music technology
technology innovation
jazz
pop music
personal piano
distributed cognition
improvisation
composition
performance studies
interaction
interconnectivitiy
memories
augmented
palette
sound art
sound
sound engineering
microphones
VDP::Humaniora: 000::Musikkvitenskap: 110::Annen musikkvitenskap: 119