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Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease 期刊论文
NATURE, 2020, 577 (7790) : 399-+
作者:  Gate, David;  Saligrama, Naresha;  Leventhal, Olivia;  Yang, Andrew C.;  Unger, Michael S.;  Middeldorp, Jinte;  Chen, Kelly;  Lehallier, Benoit;  Channappa, Divya;  De Los Santos, Mark B.;  McBride, Alisha;  Pluvinage, John;  Elahi, Fanny;  Tam, Grace Kyin-Ye;  Kim, Yongha;  Greicius, Michael;  Wagner, Anthony D.;  Aigner, Ludwig;  Galasko, Douglas R.;  Davis, Mark M.;  Wyss-Coray, Tony
收藏  |  浏览/下载：8/0  |  提交时间：2020/07/03

Alzheimer'  s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function(1). However, little is known about the contribution of the adaptive immune response in Alzheimer'  s disease(2). Here, using integrated analyses of multiple cohorts, we identify peripheral and central adaptive immune changes in Alzheimer'  s disease. First, we performed mass cytometry of peripheral blood mononuclear cells and discovered an immune signature of Alzheimer'  s disease that consists of increased numbers of CD8(+) T effector memory CD45RA(+) (T-EMRA) cells. In a second cohort, we found that CD8(+) T-EMRA cells were negatively associated with cognition. Furthermore, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these cells. Notably, by using several strategies of single-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8(+) T-EMRA cells in the cerebrospinal fluid of patients with Alzheimer'  s disease. Finally, we used machine learning, cloning and peptide screens to demonstrate the specificity of clonally expanded TCRs in the cerebrospinal fluid of patients with Alzheimer'  s disease to two separate Epstein-Barr virus antigens. These results reveal an adaptive immune response in the blood and cerebrospinal fluid in Alzheimer'  s disease and provide evidence of clonal, antigen-experienced T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration.


  
Knowing when knowledge performs its power in ecological economics 期刊论文
ECOLOGICAL ECONOMICS, 2020, 169
作者:  Hukkinen, Janne I.
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/02
Perfonnativity  Knowledge brokering  Science-policy interaction  Sustainability transitions  Distributed cognition  Second order knowledge  
Which group should policies target? Effects of incentive policies and product cognitions for electric vehicle adoption among Chinese consumers 期刊论文
ENERGY POLICY, 2019, 135
作者:  Yang, Shu;  Cheng, Peng;  Li, Jun;  Wang Shanyong
收藏  |  浏览/下载：11/0  |  提交时间：2020/02/17
Electric vehicles  Policy perception  Product cognition  Adoption intention  
Smart is the new sexy: female mountain chickadees increase reproductive investment when mated to males with better spatial cognition 期刊论文
ECOLOGY LETTERS, 2019, 22 (6) : 897-903
作者:  Branch, Carrie L.;  Pitera, Angela M.;  Kozlovsky, Dovid Y.;  Bridge, Eli S.;  Pravosudov, Vladimir V.
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/26
Chickadee  cognition  fitness  food caching  parental investment  reproduction  spatial memory  
Teaching climate change in middle schools and high schools: investigating STEM education's deficit model 期刊论文
CLIMATIC CHANGE, 2018, 149: 305-317
作者:  Plutzer, Eric;  Hannah, A. Lee
收藏  |  浏览/下载：11/0  |  提交时间：2019/04/09
Climate change  Education  Motivated cognition  Political polarization  
Social complexity and kinship in animal societies 期刊论文
ECOLOGY LETTERS, 2018, 21 (8) : 1129-1134
作者:  Lukas, Dieter;  Clutton-Brock, Tim
收藏  |  浏览/下载：5/0  |  提交时间：2019/04/09
Behaviour  cognition  competition  cooperation  evolution  kinship  relatedness  social complexity  sociality  
The HyPer(sonal) Piano Project : towards a (per)sonal topography of grand piano and electronics [interactive pdf] 科技报告
来源：Center for International Climate and Environmental Research-Oslo (CICERO). 出版年： 2016
作者:  Qvenild, Morten
收藏  |  浏览/下载：3/0  |  提交时间：2019/04/05
hyperinstrument  piano  interagency  music technology  technology innovation  jazz  pop music  personal piano  distributed cognition  improvisation  composition  performance studies  interaction  interconnectivitiy  memories  augmented  palette  sound art  sound  sound engineering  microphones  VDP::Humaniora: 000::Musikkvitenskap: 110::Annen musikkvitenskap: 119