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A reference map of the human binary protein interactome 期刊论文
NATURE, 2020, 580 (7803) : 402-+
作者:  Fan, Chen;  Sukomon, Nattakan;  Flood, Emelie;  Rheinberger, Jan;  Allen, Toby W.;  Nimigean, Crina M.
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships(1,2). Here we present a human '  all-by-all'  reference interactome map of human binary protein interactions, or '  HuRI'  . With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome(3), transcriptome(4) and proteome(5) data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.


  
Demonstration of cooling by the Muon Ionization Cooling Experiment 期刊论文
NATURE, 2020, 578 (7793) : 53-+
作者:  Zheng, Wen;  Zhao, Wenjing;  Wu, Meng;  Song, Xinyang;  Caro, Florence;  Sun, Ximei;  Gazzaniga, Francesca;  Stefanetti, Giuseppe;  Oh, Sungwhan;  Mekalanos, John J.;  Kasper, Dennis L.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

The use of accelerated beams of electrons, protons or ions has furthered the development of nearly every scientific discipline. However, high-energy muon beams of equivalent quality have not yet been delivered. Muon beams can be created through the decay of pions produced by the interaction of a proton beam with a target. Such '  tertiary'  beams have much lower brightness than those created by accelerating electrons, protons or ions. High-brightness muon beams comparable to those produced by state-of-the-art electron, proton and ion accelerators could facilitate the study of lepton-antilepton collisions at extremely high energies and provide well characterized neutrino beams(1-6). Such muon beams could be realized using ionization cooling, which has been proposed to increase muon-beam brightness(7,8). Here we report the realization of ionization cooling, which was confirmed by the observation of an increased number of low-amplitude muons after passage of the muon beam through an absorber, as well as an increase in the corresponding phase-space density. The simulated performance of the ionization cooling system is consistent with the measured data, validating designs of the ionization cooling channel in which the cooling process is repeated to produce a substantial cooling effect(9-11). The results presented here are an important step towards achieving the muon-beam quality required to search for phenomena at energy scales beyond the reach of the Large Hadron Collider at a facility of equivalent or reduced wfootprint(6).


  
Multi-century trends to wetter winters and drier summers in the England and Wales precipitation series explained by observational and sampling bias in early records 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019
作者:  Murphy, Conor;  Wilby, Robert L.;  Matthews, Tom K. R.;  Thorne, Peter;  Broderick, Ciaran;  Fealy, Rowan;  Hall, Julia;  Harrigan, Shaun;  Jones, Phil;  McCarthy, Gerard;  MacDonald, Neil;  Noone, Simon;  Ryan, Ciara
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
data quality  drier summers  England Wales Precipitation  Gordon Manley  historical climate  sleet and snow  wetter winters  
Energy performance certificates - New opportunities for data-enabled urban energy policy instruments? 期刊论文
ENERGY POLICY, 2019, 127: 486-499
作者:  Pasichnyi, Oleksii;  Wallin, Jorgen;  Levihn, Fabian;  Shahrokni, Hossein;  Kordas, Olga
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/26
Energy performance certificate (EPC)  Building energy efficiency  Data applications  Data quality  Sweden  
The NASA Wallops Flight Facility Digital Ozonesonde Record: Reprocessing, Uncertainties, and Dual Launches 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (6) : 3565-3582
作者:  Witte, Jacquelyn C.;  Thompson, Anne M.;  Schmidlin, F. J.;  Northam, E. Thomas;  Wolff, Katherine R.;  Brothers, George B.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/26
instruments and techniques  data management  preservation  rescue  uncertainty  metadata: quality  
Homogenization of Monthly Ground Surface Temperature in China during 1961-2016 and Performances of GLDAS Reanalysis Products 期刊论文
JOURNAL OF CLIMATE, 2019, 32 (4) : 1121-1135
作者:  Xu, Wenhui;  Sun, Chenghu;  Zuo, Jingqing;  Ma, Zhuguo;  Li, Weijing;  Yang, Song
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
Climate change  Automatic weather stations  Data quality control  Surface observations  Changepoint analysis  
Balance of Emission and Dynamical Controls on Ozone During the Korea-United States Air Quality Campaign From Multiconstituent Satellite Data Assimilation 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (1) : 387-413
作者:  Miyazaki, K.;  Sekiya, T.;  Fu, D.;  Bowman, K. W.;  Kulawik, S. S.;  Sudo, K.;  Walker, T.;  Kanaya, Y.;  Takigawa, M.;  Ogochi, K.;  Eskes, H.;  Boersma, K. F.;  Thompson, A. M.;  Gaubert, B.;  Barre, J.;  Emmons, L. K.
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
data assimilation  satellite  air quality  ozone  Asia  emission  
Aquatic insects rich in omega-3 fatty acids drive breeding success in a widespread bird 期刊论文
ECOLOGY LETTERS, 2018, 21 (12) : 1812-1820
作者:  Twining, Cornelia Wingfield;  Shipley, Jeremy Ryan;  Winkler, David W.
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
Aerial insectivores  breeding success  ecological subsidies  food quality  highly unsaturated omega-3 fatty acids  long-term ecological data  Tree Swallows  
Long-Term Monitoring of Macroinvertebrate Communities Over 2,300 km of the Murray River Reveals Ecological Signs of Salinity Mitigation Against a Backdrop of Climate Variability 期刊论文
WATER RESOURCES RESEARCH, 2018, 54 (9) : 7004-7028
作者:  Paul, Warren L.;  Cook, Robert A.;  Suter, Phillip J.;  Clarke, K. Robert;  Shackleton, Michael E.;  McInerney, Paul J.;  Hawking, John H.
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
river regulation  irrigated agriculture  land use and management  flood  drought  water quality  multivariate species data  
Homogeneity analysis of wind data from 213 m high Cabauw tower 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2018, 38: E1076-E1090
作者:  Petrovic, Predrag;  Romanic, Djordje;  Curic, Mladjen
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
homogeneity  Cabauw  ReDistribution Method  wind climate  The Netherlands  internal boundary layer  data quality  Monte-Carlo method