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Antagonistic cooperativity between crystal growth modifiers 期刊论文
NATURE, 2020, 577 (7791) : 497-+
作者:  Ma, Wenchuan;  Lutsko, James F.;  Rimer, Jeffrey D.;  Vekilov, Peter G.
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/03

Inhibitor pairs that suppress the crystallization of haematin, which is a part of malaria parasites'  physiology, show unexpected antagonism due to attenuation of step pinning by kink blockers.


Ubiquitous processes in nature and the industry exploit crystallization from multicomponent environments(1-5)  however, laboratory efforts have focused on the crystallization of pure solutes(6,7) and the effects of single growth modifiers(8,9). Here we examine the molecular mechanisms employed by pairs of inhibitors in blocking the crystallization of haematin, which is a model organic compound with relevance to the physiology of malaria parasites(10,11). We use a combination of scanning probe microscopy and molecular modelling to demonstrate that inhibitor pairs, whose constituents adopt distinct mechanisms of haematin growth inhibition, kink blocking and step pinning(12,13), exhibit both synergistic and antagonistic cooperativity depending on the inhibitor combination and applied concentrations. Synergism between two crystal growth modifiers is expected, but the antagonistic cooperativity of haematin inhibitors is not reflected in current crystal growth models. We demonstrate that kink blockers reduce the line tension of step edges, which facilitates both the nucleation of crystal layers and step propagation through the gates created by step pinners. The molecular viewpoint on cooperativity between crystallization modifiers provides guidance on the pairing of modifiers in the synthesis of crystalline materials. The proposed mechanisms indicate strategies to understand and control crystallization in both natural and engineered systems, which occurs in complex multicomponent media(1-3,8,9). In a broader context, our results highlight the complexity of crystal-modifier interactions mediated by the structure and dynamics of the crystal interface.


  
Interactions between wind and fire disturbance in forests: Competing amplifying and buffering effects 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 436: 117-128
作者:  Cannon, Jeffery B.;  Henderson, Suzanne K.;  Bailey, Michael H.;  Peterson, Chris J.
收藏  |  浏览/下载：9/0  |  提交时间：2019/04/09
Amplifying effects  Antagonism  Buffering effects  Disturbance interactions  Prescribed fire  Synergism  Tornado  Wind damage  
Advancing understanding and prediction in multiple stressor research through a mechanistic basis for null models 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (5) : 1817-1826
作者:  Schaefer, Ralf B.;  Piggott, Jeremy J.
收藏  |  浏览/下载：5/0  |  提交时间：2019/04/09
antagonism  mechanism  mixtures  multiple stress  null models  stressors  synergism  
When things don't add up: quantifying impacts of multiple stressors from individual metabolism to ecosystem processing 期刊论文
ECOLOGY LETTERS, 2018, 21 (4) : 568-577
作者:  Galic, Nika;  Sullivan, Lauren L.;  Grimm, Volker;  Forbes, Valery E.
收藏  |  浏览/下载：4/0  |  提交时间：2019/04/09
Antagonism  detritivores  ecosystem services  energy budgets  individual-based model  population dynamics  stressor interactions  synergism