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Projections of hydrofluorocarbon (HFC) emissions and the resulting global warming based on recent trends in observed abundances and current policies 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Guus J. M. Velders, John S. Daniel, Stephen A. Montzka, Isaac Vimont, Matthew Rigby, Paul B. Krummel, Jens Muhle, Simon O'Doherty, Ronald G. Prinn, Ray F. Weiss, and Dickon Young
收藏  |  浏览/下载:18/0  |  提交时间:2022/06/24
Rate of mass loss from the Greenland Ice Sheet will exceed Holocene values this century 期刊论文
Nature, 2020
作者:  Jason P. Briner;  Joshua K. Cuzzone;  Jessica A. Badgeley;  Nicolá;  s E. Young;  Eric J. Steig;  Mathieu Morlighem;  Nicole-Jeanne Schlegel;  Gregory J. Hakim;  Joerg M. Schaefer;  Jesse V. Johnson;  Alia J. Lesnek;  Elizabeth K. Thomas;  Estelle Allan;  Ole Bennike;  Allison A. Cluett;  Beata Csatho;  Anne de Vernal;  Jacob Downs;  Eric Larour;  Sophie Nowicki
收藏  |  浏览/下载:10/0  |  提交时间:2020/10/12
Bending the curve of terrestrial biodiversity needs an integrated strategy 期刊论文
Nature, 2020
作者:  David Leclè;  re;  Michael Obersteiner;  Mike Barrett;  Stuart H. M. Butchart;  Abhishek Chaudhary;  Adriana De Palma;  Fabrice A. J. DeClerck;  Moreno Di Marco;  Jonathan C. Doelman;  Martina Dü;  rauer;  Robin Freeman;  Michael Harfoot;  Tomoko Hasegawa;  Stefanie Hellweg;  Jelle P. Hilbers;  Samantha L. L. Hill;  Florian Humpenö;  der;  Nancy Jennings;  Tamá;  s Krisztin;  Georgina M. Mace;  Haruka Ohashi;  Alexander Popp;  Andy Purvis;  Aafke M. Schipper;  Andrzej Tabeau;  Hugo Valin;  Hans van Meijl;  Willem-Jan van Zeist;  Piero Visconti;  Rob Alkemade;  Rosamunde Almond;  Gill Bunting;  Neil D. Burgess;  Sarah E. Cornell;  Fulvio Di Fulvio;  Simon Ferrier;  Steffen Fritz;  Shinichiro Fujimori;  Monique Grooten;  Thomas Harwood;  Petr Havlí;  k;  Mario Herrero;  Andrew J. Hoskins;  Martin Jung;  Tom Kram;  Hermann Lotze-Campen;  Tetsuya Matsui;  Carsten Meyer;  Deon Nel;  Tim Newbold;  Guido Schmidt-Traub;  Elke Stehfest;  Bernardo B. N. Strassburg;  Detlef P. van Vuuren;  Chris Ware;  James E. M. Watson;  Wenchao Wu;  Lucy Young
收藏  |  浏览/下载:77/0  |  提交时间:2020/09/14
Southern Ocean carbon sink enhanced by sea-ice feedbacks at the Antarctic Cold Reversal 期刊论文
NATURE GEOSCIENCE, 2020, 13 (7) : 489-+
作者:  Fogwill, C. J.;  Turney, C. S. M.;  Menviel, L.;  Baker, A.;  Weber, M. E.;  Ellis, B.;  Thomas, Z. A.;  Golledge, N. R.;  Etheridge, D.;  Rubino, M.;  Thornton, D. P.;  van Ommen, T. D.;  Moy, A. D.;  Curran, M. A. J.;  Davies, S.;  Bird, M., I;  Munksgaard, N. C.;  Rootes, C. M.;  Millman, H.;  Vohra, J.;  Rivera, A.;  Mackintosh, A.;  Pike, J.;  Hall, I. R.;  Bagshaw, E. A.;  Rainsley, E.;  Bronk-Ramsey, C.;  Montenari, M.;  Cage, A. G.;  Harris, M. R. P.;  Jones, R.;  Power, A.;  Love, J.;  Young, J.;  Weyrich, L. S.;  Cooper, A.
收藏  |  浏览/下载:14/0  |  提交时间:2020/06/29
Inner ear sensory system changes as extinct crocodylomorphs transitioned from land to water 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Julia A. Schwab;  Mark T. Young;  James M. Neenan;  Stig A. Walsh;  Lawrence M. Witmer;  Yanina Herrera;  Ronan Allain;  Christopher A. Brochu;  Jonah N. Choiniere;  James M. Clark;  Kathleen N. Dollman;  Steve Etches;  Guido Fritsch;  Paul M. Gignac;  Alexander Ruebenstahl;  Sven Sachs;  Alan H. Turner;  Patrick Vignaud;  Eric W. Wilberg;  Xing Xu;  Lindsay E. Zanno;  Stephen L. Brusatte
收藏  |  浏览/下载:11/0  |  提交时间:2020/05/13
Inner ear sensory system changes as extinct crocodylomorphs transitioned from land to water 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (19) : 10422-10428
作者:  Schwab, Julia A.;  Young, Mark T.;  Neenan, James M.;  Walsh, Stig A.;  Witmer, Lawrence M.;  Herrera, Yanina;  Allain, Ronan;  Brochu, Christopher A.;  Choiniere, Jonah N.;  Clark, James M.;  Dollman, Kathleen N.;  Etches, Steve;  Fritsch, Guido;  Gignac, Paul M.;  Ruebenstahl, Alexander;  Sachs, Sven;  Turner, Alan H.;  Vignaud, Patrick;  Wilberg, Eric W.;  Xu, Xing;  Zanno, Lindsay E.;  Brusatte, Stephen L.
收藏  |  浏览/下载:9/0  |  提交时间:2020/05/13
bony labyrinth  vestibular system  morphology  thalattosuchia  CT scanning  
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline 期刊论文
NATURE, 2020, 581 (7806) : 70-+
作者:  Doherty, Tiarnan A. S.;  Winchester, Andrew J.;  Macpherson, Stuart;  Johnstone, Duncan N.;  Pareek, Vivek;  Tennyson, Elizabeth M.;  Kosar, Sofiia;  Kosasih, Felix U.;  Anaya, Miguel;  Abdi-Jalebi, Mojtaba;  Andaji-Garmaroudi, Zahra;  Wong, E. Laine;  Madeo, Julien;  Chiang, Yu-Hsien;  Park, Ji-Sang;  Jung, Young-Kwang;  Petoukhoff, Christopher E.;  Divitini, Giorgio;  Man, Michael K. L.;  Ducati, Caterina;  Walsh, Aron;  Midgley, Paul A.;  Dani, Keshav M.;  Stranks, Samuel D.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Breakdown of the blood-brain barrier in individuals carrying the epsilon 4 allele of the APOE gene, but not the epsilon 3 allele, increases with and predicts cognitive impairment and is independent of amyloid beta or tau pathology.


Vascular contributions to dementia and Alzheimer'  s disease are increasingly recognized(1-6). Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction(7), including the early clinical stages of Alzheimer'  s disease(5,8-10). The E4 variant of apolipoprotein E (APOE4), the main susceptibility gene for Alzheimer'  s disease(11-14), leads to accelerated breakdown of the BBB and degeneration of brain capillary pericytes(15-19), which maintain BBB integrity(20-22). It is unclear, however, whether the cerebrovascular effects of APOE4 contribute to cognitive impairment. Here we show that individuals bearing APOE4 (with the epsilon 3/epsilon 4 or epsilon 4/epsilon 4 alleles) are distinguished from those without APOE4 (epsilon 3/epsilon 3) by breakdown of the BBB in the hippocampus and medial temporal lobe. This finding is apparent in cognitively unimpaired APOE4 carriers and more severe in those with cognitive impairment, but is not related to amyloid-beta or tau pathology measured in cerebrospinal fluid or by positron emission tomography(23). High baseline levels of the BBB pericyte injury biomarker soluble PDGFR beta(7,8) in the cerebrospinal fluid predicted future cognitive decline in APOE4 carriers but not in non-carriers, even after controlling for amyloid-beta and tau status, and were correlated with increased activity of the BBB-degrading cyclophilin A-matrix metalloproteinase-9 pathway(19) in cerebrospinal fluid. Our findings suggest that breakdown of the BBB contributes to APOE4-associated cognitive decline independently of Alzheimer'  s disease pathology, and might be a therapeutic target in APOE4 carriers.


  
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.


  
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage (vol 551, pg 629, 2017) 期刊论文
NATURE, 2020, 580 (7802) : E5-E5
作者:  Lu, Zhihao;  Zou, Jianling;  Li, Shuang;  Topper, Michael J.;  Tao, Yong;  Zhang, Hao;  Jiao, Xi;  Xie, Wenbing;  Kong, Xiangqian;  Vaz, Michelle;  Li, Huili;  Cai, Yi;  Xia, Limin;  Huang, Peng;  Rodgers, Kristen;  Lee, Beverly;  Riemer, Joanne B.;  Day, Chi-Ping;  Yen, Ray-Whay Chiu;  Cui, Ying;  Wang, Yujiao;  Wang, Yanni;  Zhang, Weiqiang;  Easwaran, Hariharan;  Hulbert, Alicia;  Kim, KiBem;  Juergens, Rosalyn A.;  Yang, Stephen C.;  Battafarano, Richard J.;  Bush, Errol L.;  Broderick, Stephen R.;  Cattaneo, Stephen M.;  Brahmer, Julie R.;  Rudin, Charles M.;  Wrangle, John;  Mei, Yuping;  Kim, Young J.;  Zhang, Bin;  Wang, Ken Kang-Hsin;  Forde, Patrick M.;  Margolick, Joseph B.;  Nelkin, Barry D.;  Zahnow, Cynthia A.;  Pardoll, Drew M.;  Housseau, Franck;  Baylin, Stephen B.;  Shen, Lin;  Brock, Malcolm V.
收藏  |  浏览/下载:27/0  |  提交时间:2020/07/03
Nightside condensation of iron in an ultrahot giant exoplanet 期刊论文
NATURE, 2020, 580 (7805) : 597-+
作者:  Lu, Zhihao;  Zou, Jianling;  Li, Shuang;  Topper, Michael J.;  Tao, Yong;  Zhang, Hao;  Jiao, Xi;  Xie, Wenbing;  Kong, Xiangqian;  Vaz, Michelle;  Li, Huili;  Cai, Yi;  Xia, Limin;  Huang, Peng;  Rodgers, Kristen;  Lee, Beverly;  Riemer, Joanne B.;  Day, Chi-Ping;  Yen, Ray-Whay Chiu;  Cui, Ying;  Wang, Yujiao;  Wang, Yanni;  Zhang, Weiqiang;  Easwaran, Hariharan;  Hulbert, Alicia;  Kim, KiBem;  Juergens, Rosalyn A.;  Yang, Stephen C.;  Battafarano, Richard J.;  Bush, Errol L.;  Broderick, Stephen R.;  Cattaneo, Stephen M.;  Brahmer, Julie R.;  Rudin, Charles M.;  Wrangle, John;  Mei, Yuping;  Kim, Young J.;  Zhang, Bin;  Wang, Ken Kang-Hsin;  Forde, Patrick M.;  Margolick, Joseph B.;  Nelkin, Barry D.;  Zahnow, Cynthia A.;  Pardoll, Drew M.;  Housseau, Franck;  Baylin, Stephen B.;  Shen, Lin;  Brock, Malcolm V.
收藏  |  浏览/下载:59/0  |  提交时间:2020/07/03

Ultrahot giant exoplanets receive thousands of times Earth'  s insolation(1,2). Their high-temperature atmospheres (greater than 2,000 kelvin) are ideal laboratories for studying extreme planetary climates and chemistry(3-5). Daysides are predicted to be cloud-free, dominated by atomic species(6) and much hotter than nightsides(5,7,8). Atoms are expected to recombine into molecules over the nightside(9), resulting in different day and night chemistries. Although metallic elements and a large temperature contrast have been observed(10-14), no chemical gradient has been measured across the surface of such an exoplanet. Different atmospheric chemistry between the day-to-night ('  evening'  ) and night-to-day ('  morning'  ) terminators could, however, be revealed as an asymmetric absorption signature during transit(4,7,15). Here we report the detection of an asymmetric atmospheric signature in the ultrahot exoplanet WASP-76b. We spectrally and temporally resolve this signature using a combination of high-dispersion spectroscopy with a large photon-collecting area. The absorption signal, attributed to neutral iron, is blueshifted by -11 +/- 0.7 kilometres per second on the trailing limb, which can be explained by a combination of planetary rotation and wind blowing from the hot dayside(16). In contrast, no signal arises from the nightside close to the morning terminator, showing that atomic iron is not absorbing starlight there. We conclude that iron must therefore condense during its journey across the nightside.


Absorption lines of iron in the dayside atmosphere of an ultrahot giant exoplanet disappear after travelling across the nightside, showing that the iron has condensed during its travel.