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Observation of Bose-Einstein condensates in an Earth-orbiting research lab 期刊论文
NATURE, 2020, 582 (7811) : 103-+
作者:  Yamamoto, Keisuke;  Venida, Anthony;  Yano, Julian;  Biancur, Douglas E.;  Kakiuchi, Miwako;  Gupta, Suprit;  Sohn, Albert S. W.;  Mukhopadhyay, Subhadip;  Lin, Elaine Y.;  Parker, Seth J.;  Banh, Robert S.;  Paulo, Joao A.;  Wen, Kwun Wah;  Debnath, Jayanta;  Kim, Grace E.;  Mancias, Joseph D.;  Fearon, Douglas T.;  Perera, Rushika M.;  Kimmelman, Alec C.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Quantum mechanics governs the microscopic world, where low mass and momentum reveal a natural wave-particle duality. Magnifying quantum behaviour to macroscopic scales is a major strength of the technique of cooling and trapping atomic gases, in which low momentum is engineered through extremely low temperatures. Advances in this field have achieved such precise control over atomic systems that gravity, often negligible when considering individual atoms, has emerged as a substantial obstacle. In particular, although weaker trapping fields would allow access to lower temperatures(1,2), gravity empties atom traps that are too weak. Additionally, inertial sensors based on cold atoms could reach better sensitivities if the free-fall time of the atoms after release from the trap could be made longer(3). Planetary orbit, specifically the condition of perpetual free-fall, offers to lift cold-atom studies beyond such terrestrial limitations. Here we report production of rubidium Bose-Einstein condensates (BECs) in an Earth-orbiting research laboratory, the Cold Atom Lab. We observe subnanokelvin BECs in weak trapping potentials with free-expansion times extending beyond one second, providing an initial demonstration of the advantages offered by a microgravity environment for cold-atom experiments and verifying the successful operation of this facility. With routine BEC production, continuing operations will support long-term investigations of trap topologies unique to microgravity(4,5), atom-laser sources(6), few-body physics(7,8)and pathfinding techniques for atom-wave interferometry(9-12).


  
Nonlinear Interactions Between Radiation Belt Electrons and Chorus Waves: Dependence on Wave Amplitude Modulation 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (4)
作者:  Gan, L.;  Li, W.;  Ma, Q.;  Albert, J. M.;  Artemyev, A., V;  Bortnik, J.
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/02
The physical oceanography of the transport of floating marine debris 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (2)
作者:  van Sebille, Erik;  Aliani, Stefano;  Law, Kara Lavender;  Maximenko, Nikolai;  Alsina, Jose M.;  Bagaev, Andrei;  Bergmann, Melanie;  Chapron, Bertrand;  Chubarenko, Irina;  Cozar, Andres;  Delandmeter, Philippe;  Egger, Matthias;  Fox-Kemper, Baylor;  Garaba, Shungudzemwoyo P.;  Goddijn-Murphy, Lonneke;  Hardesty, Britta Denise;  Hoffman, Matthew J.;  Isobe, Atsuhiko;  Jongedijk, Cleo E.;  Kaandorp, Mikael L. A.;  Khatmullina, Liliya;  Koelmans, Albert A.;  Kukulka, Tobias;  Laufkotter, Charlotte;  Lebreton, Laurent;  Lobelle, Delphine;  Maes, Christophe;  Martinez-Vicente, Victor;  Maqueda, Miguel Angel Morales;  Poulain-Zarcos, Marie;  Rodriguez, Ernesto;  Ryan, Peter G.;  Shanks, Alan L.;  Shim, Won Joon;  Suaria, Giuseppe;  Thiel, Martin;  van den Bremer, Ton S.;  Wichmann, David
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/02
marine debris  physical oceanography  ocean circulation  remote sensing  fluid dynamics  
Mechanical regulation of glycolysis via cytoskeleton architecture 期刊论文
NATURE, 2020, 578 (7796) : 621-+
作者:  Faivre, Emily J.;  McDaniel, Keith F.;  Albert, Daniel H.;  Mantena, Srinivasa R.;  Plotnik, Joshua P.;  Wilcox, Denise;  Zhang, Lu;  Bui, Mai H.;  Sheppard, George S.;  Wang, Le;  Sehgal, Vasudha;  Lin, Xiaoyu;  Huang, Xiaoli;  Lu, Xin;  Uziel, Tamar;  Hessler, Paul;  Lam, Lloyd T.;  Bellin, Richard J.;  Mehta, Gaurav;  Fidanze, Steve;  Pratt, John K.;  Liu, Dachun;  Hasvold, Lisa A.;  Sun, Chaohong;  Panchal, Sanjay C.;  Nicolette, John J.;  Fossey, Stacey L.;  Park, Chang H.;  Longenecker, Kenton;  Bigelow, Lance;  Torrent, Maricel;  Rosenberg, Saul H.;  Kati, Warren M.;  Shen, Yu
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The mechanics of the cellular microenvironment continuously modulates cell functions such as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal remodelling and actomyosin contractility(1-3). Although all of these processes consume energy(4,5), it is unknown whether and how cells adapt their metabolic activity to variable mechanical cues. Here we report that the transfer of human bronchial epithelial cells from stiff to soft substrates causes a downregulation of glycolysis via proteasomal degradation of the rate-limiting metabolic enzyme phosphofructokinase (PFK). PFK degradation is triggered by the disassembly of stress fibres, which releases the PFK-targeting E3 ubiquitin ligase tripartite motif (TRIM)-containing protein 21 (TRIM21). Transformed non-small-cell lung cancer cells, which maintain high glycolytic rates regardless of changing environmental mechanics, retain PFK expression by downregulating TRIM21, and by sequestering residual TRIM21 on a stress-fibre subset that is insensitive to substrate stiffness. Our data reveal a mechanism by which glycolysis responds to architectural features of the actomyosin cytoskeleton, thus coupling cell metabolism to the mechanical properties of the surrounding tissue. These processes enable normal cells to tune energy production in variable microenvironments, whereas the resistance of the cytoskeleton in response to mechanical cues enables the persistence of high glycolytic rates in cancer cells despite constant alterations of the tumour tissue.


Glycolysis in normal epithelial cells responds to microenvironmental mechanics via the modulation of actin bundles that sequester the phosphofructokinase-targeting ubiquitin ligase TRIM21, a process superseded by persistent actin bundles in cancer cells.


  
Principles for knowledge co-production in sustainability research 期刊论文
NATURE SUSTAINABILITY, 2020, 3 (3) : 182-190
作者:  Norstrom, Albert, V;  Cvitanovic, Christopher;  Lof, Marie F.;  West, Simon;  Wyborn, Carina;  Balvanera, Patricia;  Bednarek, Angela T.;  Bennett, Elena M.;  Biggs, Reinette;  de Bremond, Ariane;  Campbell, Bruce M.;  Canadell, Josep G.;  Carpenter, Stephen R.;  Folke, Carl;  Fulton, Elizabeth A.;  Gaffney, Owen;  Gelcich, Stefan;  Jouffray, Jean-Baptiste;  Leach, Melissa;  Le Tissier, Martin;  Martin-Lopez, Berta;  Louder, Elena;  Loutre, Marie-France;  Meadow, Alison M.;  Nagendra, Harini;  Payne, Davnah;  Peterson, Garry D.;  Reyers, Belinda;  Scholes, Robert;  Speranza, Chinwe Ifejika;  Spierenburg, Marja;  Stafford-Smith, Mark;  Tengo, Maria;  van der Hel, Sandra;  van Putten, Ingrid;  Osterblom, Henrik
收藏  |  浏览/下载:19/0  |  提交时间:2020/05/13
Ice-nucleating particle versus ice crystal number concentration in altocumulus and cirrus layers embedded in Saharan dust: a closure study 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (23) : 15087-15115
作者:  Ansmann, Albert;  Mamouri, Rodanthi-Elisavet;  Buehl, Johannes;  Seifert, Patric;  Engelmann, Ronny;  Hofer, Julian;  Nisantzi, Argyro;  Atkinson, James D.;  Kanji, Zamin A.;  Sierau, Berko;  Vrekoussis, Mihalis;  Sciare, Jean
收藏  |  浏览/下载:13/0  |  提交时间:2020/02/17
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Jakobsson, Magnus E.;  Malecki, Jedrzej M.;  Halabelian, Levon;  Nilges, Benedikt S.;  Pinto, Rita;  Kudithipudi, Srikanth;  Munk, Stephanie;  Davydova, Erna;  Zuhairi, Fawzi R.;  Arrowsmith, Cheryl H.;  Jeltsch, Albert;  Leidel, Sebastian A.;  Olsen, Jesper V.;  Falnes, Pal O.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Targeting cardiac fibrosis with engineered T cells 期刊论文
NATURE, 2019, 573 (7774) : 430-+
作者:  Aghajanian, Haig;  Kimura, Toru;  Rurik, Joel G.;  Hancock, Aidan S.;  Leibowitz, Michael S.;  Li, Li;  Scholler, John;  Monslow, James;  Lo, Albert;  Han, Wei;  Wang, Tao;  Bedi, Kenneth;  Morley, Michael P.;  Saldana, Ricardo A. Linares;  Bolar, Nikhita A.;  McDaid, Kendra;  Assenmacher, Charles-Antoine;  Smith, Cheryl L.;  Wirth, Dagmar;  June, Carl H.;  Margulies, Kenneth B.;  Jain, Rajan;  Pure, Ellen;  Albelda, Steven M.;  Epstein, Jonathan A.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Exploring genetic interaction manifolds constructed from rich single-cell phenotypes 期刊论文
SCIENCE, 2019, 365 (6455) : 786-+
作者:  Norman, Thomas M.;  Horlbeck, Max A.;  Replogle, Joseph M.;  Ge, Alex Y.;  Xu, Albert;  Jost, Marco;  Gilbert, Luke A.;  Weissman, Jonathan S.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Cryptic phenology in plants: Case studies, implications, and recommendations 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (11) : 3591-3608
作者:  Albert, Loren P.;  Restrepo-Coupe, Natalia;  Smith, Marielle N.;  Wu, Jin;  Chavana-Bryant, Cecilia;  Prohaska, Neill;  Taylor, Tyeen C.;  Martins, Giordane A.;  Ciais, Philippe;  Mao, Jiafu;  Arain, M. Altaf;  Li, Wei;  Shi, Xiaoying;  Ricciuto, Daniel M.;  Huxman, Travis E.;  McMahon, Sean M.;  Saleska, Scott R.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
climate change  dynamic global vegetation models  plant ecology  plant physiology  seasonality  terrestrial biosphere models  whole plant biology