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Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 期刊论文
Science, 2021
作者:  Tia A. Tummino;  Veronica V. Rezelj;  Benoit Fischer;  Audrey Fischer;  Matthew J. O’Meara;  Blandine Monel;  Thomas Vallet;  Kris M. White;  Ziyang Zhang;  Assaf Alon;  Heiko Schadt;  Henry R. O’Donnell;  Jiankun Lyu;  Romel Rosales;  Briana L. McGovern;  Raveen Rathnasinghe;  Sonia Jangra;  Michael Schotsaert;  Jean-René Galarneau;  Nevan J. Krogan;  Laszlo Urban;  Kevan M. Shokat;  Andrew C. Kruse;  Adolfo García-Sastre;  Olivier Schwartz;  Francesca Moretti;  Marco Vignuzzi;  Francois Pognan;  Brian K. Shoichet
收藏  |  浏览/下载：26/0  |  提交时间：2021/08/10
Using DNA to reunify separated migrant families 期刊论文
Science, 2021
作者:  Elizabeth Barnert;  Sara H. Katsanis;  Ranit Mishori;  Jennifer K. Wagner;  Richard F. Selden;  Diana Madden;  Dan Berger;  Henry Erlich;  Kathryn Hampton;  Andreas Kleiser;  Alessandra La Vaccara;  Thomas J. Parsons;  Fredy A. Peccerelli;  Mariana Herrera Piñero;  Michael J. Stebbins;  Patricia Vásquez;  Curren W. Warf;  Thomas J. White;  Eric Stover;  M. Veronica Svetaz
收藏  |  浏览/下载：16/0  |  提交时间：2021/06/15
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease 期刊论文
Science, 2021
作者:  Sebastian Günther;  Patrick Y. A. Reinke;  Yaiza Fernández-García;  Julia Lieske;  Thomas J. Lane;  Helen M. Ginn;  Faisal H. M. Koua;  Christiane Ehrt;  Wiebke Ewert;  Dominik Oberthuer;  Oleksandr Yefanov;  Susanne Meier;  Kristina Lorenzen;  Boris Krichel;  Janine-Denise Kopicki;  Luca Gelisio;  Wolfgang Brehm;  Ilona Dunkel;  Brandon Seychell;  Henry Gieseler;  Brenna Norton-Baker;  Beatriz Escudero-Pérez;  Martin Domaracky;  Sofiane Saouane;  Alexandra Tolstikova;  Thomas A. White;  Anna Hänle;  Michael Groessler;  Holger Fleckenstein;  Fabian Trost;  Marina Galchenkova;  Yaroslav Gevorkov;  Chufeng Li;  Salah Awel;  Ariana Peck;  Miriam Barthelmess;  Frank Schlünzen;  P. Lourdu Xavier;  Nadine Werner;  Hina Andaleeb;  Najeeb Ullah;  Sven Falke;  Vasundara Srinivasan;  Bruno Alves França;  Martin Schwinzer;  Hévila Brognaro;  Cromarte Rogers;  Diogo Melo;  Joanna J. Zaitseva-Doyle;  Juraj Knoska;  Gisel E. Peña-Murillo;  Aida Rahmani Mashhour;  Vincent Hennicke;  Pontus Fischer;  Johanna Hakanpää;  Jan Meyer;  Philip Gribbon;  Bernhard Ellinger;  Maria Kuzikov;  Markus Wolf;  Andrea R. Beccari;  Gleb Bourenkov;  David von Stetten;  Guillaume Pompidor;  Isabel Bento;  Saravanan Panneerselvam;  Ivars Karpics;  Thomas R. Schneider;  Maria Marta Garcia-Alai;  Stephan Niebling;  Christian Günther;  Christina Schmidt;  Robin Schubert;  Huijong Han;  Juliane Boger;  Diana C. F. Monteiro;  Linlin Zhang;  Xinyuanyuan Sun;  Jonathan Pletzer-Zelgert;  Jan Wollenhaupt;  Christian G. Feiler;  Manfred S. Weiss;  Eike-Christian Schulz;  Pedram Mehrabi;  Katarina Karničar;  Aleksandra Usenik;  Jure Loboda;  Henning Tidow;  Ashwin Chari;  Rolf Hilgenfeld;  Charlotte Uetrecht;  Russell Cox;  Andrea Zaliani;  Tobias Beck;  Matthias Rarey;  Stephan Günther;  Dusan Turk;  Winfried Hinrichs;  Henry N. Chapman;  Arwen R. Pearson;  Christian Betzel;  Alke Meents
收藏  |  浏览/下载：17/0  |  提交时间：2021/05/14
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike 期刊论文
Science, 2020
作者:  Michael Schoof;  Bryan Faust;  Reuben A. Saunders;  Smriti Sangwan;  Veronica Rezelj;  Nick Hoppe;  Morgane Boone;  Christian B. Billesbølle;  Cristina Puchades;  Caleigh M. Azumaya;  Huong T. Kratochvil;  Marcell Zimanyi;  Ishan Deshpande;  Jiahao Liang;  Sasha Dickinson;  Henry C. Nguyen;  Cynthia M. Chio;  Gregory E. Merz;  Michael C. Thompson;  Devan Diwanji;  Kaitlin Schaefer;  Aditya A. Anand;  Niv Dobzinski;  Beth Shoshana Zha;  Camille R. Simoneau;  Kristoffer Leon;  Kris M. White;  Un Seng Chio;  Meghna Gupta;  Mingliang Jin;  Fei Li;  Yanxin Liu;  Kaihua Zhang;  David Bulkley;  Ming Sun;  Amber M. Smith;  Alexandrea N. Rizo;  Frank Moss;  Axel F. Brilot;  Sergei Pourmal;  Raphael Trenker;  Thomas Pospiech;  Sayan Gupta;  Benjamin Barsi-Rhyne;  Vladislav Belyy;  Andrew W. Barile-Hill;  Silke Nock;  Yuwei Liu;  Nevan J. Krogan;  Corie Y. Ralston;  Danielle L. Swaney;  Adolfo García-Sastre;  Melanie Ott;  Marco Vignuzzi;  QCRG Structural Biology Consortium4‡;  Peter Walter;  Aashish Manglik
收藏  |  浏览/下载：17/0  |  提交时间：2020/12/22
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 期刊论文
Science, 2020
作者:  David E. Gordon;  Joseph Hiatt;  Mehdi Bouhaddou;  Veronica V. Rezelj;  Svenja Ulferts;  Hannes Braberg;  Alexander S. Jureka;  Kirsten Obernier;  Jeffrey Z. Guo;  Jyoti Batra;  Robyn M. Kaake;  Andrew R. Weckstein;  Tristan W. Owens;  Meghna Gupta;  Sergei Pourmal;  Erron W. Titus;  Merve Cakir;  Margaret Soucheray;  Michael McGregor;  Zeynep Cakir;  Gwendolyn Jang;  Matthew J. O’Meara;  Tia A. Tummino;  Ziyang Zhang;  Helene Foussard;  Ajda Rojc;  Yuan Zhou;  Dmitry Kuchenov;  Ruth Hüttenhain;  Jiewei Xu;  Manon Eckhardt;  Danielle L. Swaney;  Jacqueline M. Fabius;  Manisha Ummadi;  Beril Tutuncuoglu;  Ujjwal Rathore;  Maya Modak;  Paige Haas;  Kelsey M. Haas;  Zun Zar Chi Naing;  Ernst H. Pulido;  Ying Shi;  Inigo Barrio-Hernandez;  Danish Memon;  Eirini Petsalaki;  Alistair Dunham;  Miguel Correa Marrero;  David Burke;  Cassandra Koh;  Thomas Vallet;  Jesus A. Silvas;  Caleigh M. Azumaya;  Christian Billesbølle;  Axel F. Brilot;  Melody G. Campbell;  Amy Diallo;  Miles Sasha Dickinson;  Devan Diwanji;  Nadia Herrera;  Nick Hoppe;  Huong T. Kratochvil;  Yanxin Liu;  Gregory E. Merz;  Michelle Moritz;  Henry C. Nguyen;  Carlos Nowotny;  Cristina Puchades;  Alexandrea N. Rizo;  Ursula Schulze-Gahmen;  Amber M. Smith;  Ming Sun;  Iris D. Young;  Jianhua Zhao;  Daniel Asarnow;  Justin Biel;  Alisa Bowen;  Julian R. Braxton;  Jen Chen;  Cynthia M. Chio;  Un Seng Chio;  Ishan Deshpande;  Loan Doan;  Bryan Faust;  Sebastian Flores;  Mingliang Jin;  Kate Kim;  Victor L. Lam;  Fei Li;  Junrui Li;  Yen-Li Li;  Yang Li;  Xi Liu;  Megan Lo;  Kyle E. Lopez;  Arthur A. Melo;  Frank R. Moss;  Phuong Nguyen;  Joana Paulino;  Komal Ishwar Pawar;  Jessica K. Peters;  Thomas H. Pospiech;  Maliheh Safari;  Smriti Sangwan;  Kaitlin Schaefer;  Paul V. Thomas;  Aye C. Thwin;  Raphael Trenker;  Eric Tse;  Tsz Kin Martin Tsui;  Feng Wang;  Natalie Whitis;  Zanlin Yu;  Kaihua Zhang;  Yang Zhang;  Fengbo Zhou;  Daniel Saltzberg;  QCRG Structural Biology Consortium12†;  Anthony J. Hodder;  Amber S. Shun-Shion;  Daniel M. Williams;  Kris M. White;  Romel Rosales;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Arvind H. Patel;  Suzannah Rihn;  Mir M. Khalid;  Albert Vallejo-Gracia;  Parinaz Fozouni;  Camille R. Simoneau;  Theodore L. Roth;  David Wu;  Mohd Anisul Karim;  Maya Ghoussaini;  Ian Dunham;  Francesco Berardi;  Sebastian Weigang;  Maxime Chazal;  Jisoo Park;  James Logue;  Marisa McGrath;  Stuart Weston;  Robert Haupt;  C. James Hastie;  Matthew Elliott;  Fiona Brown;  Kerry A. Burness;  Elaine Reid;  Mark Dorward;  Clare Johnson;  Stuart G. Wilkinson;  Anna Geyer;  Daniel M. Giesel;  Carla Baillie;  Samantha Raggett;  Hannah Leech;  Rachel Toth;  Nicola Goodman;  Kathleen C. Keough;  Abigail L. Lind;  Zoonomia Consortium‡;  Reyna J. Klesh;  Kafi R. Hemphill;  Jared Carlson-Stevermer;  Jennifer Oki;  Kevin Holden;  Travis Maures;  Katherine S. Pollard;  Andrej Sali;  David A. Agard;  Yifan Cheng;  James S. Fraser;  Adam Frost;  Natalia Jura;  Tanja Kortemme;  Aashish Manglik;  Daniel R. Southworth;  Robert M. Stroud;  Dario R. Alessi;  Paul Davies;  Matthew B. Frieman;  Trey Ideker;  Carmen Abate;  Nolwenn Jouvenet;  Georg Kochs;  Brian Shoichet;  Melanie Ott;  Massimo Palmarini;  Kevan M. Shokat;  Adolfo García-Sastre;  Jeremy A. Rassen;  Robert Grosse;  Oren S. Rosenberg;  Kliment A. Verba;  Christopher F. Basler;  Marco Vignuzzi;  Andrew A. Peden;  Pedro Beltrao;  Nevan J. Krogan
收藏  |  浏览/下载：27/0  |  提交时间：2020/12/07
Long-term thermal sensitivity of Earth’s tropical forests 期刊论文
Science, 2020
作者:  Martin J. P. Sullivan;  Simon L. Lewis;  Kofi Affum-Baffoe;  Carolina Castilho;  Flávia Costa;  Aida Cuni Sanchez;  Corneille E. N. Ewango;  Wannes Hubau;  Beatriz Marimon;  Abel Monteagudo-Mendoza;  Lan Qie;  Bonaventure Sonké;  Rodolfo Vasquez Martinez;  Timothy R. Baker;  Roel J. W. Brienen;  Ted R. Feldpausch;  David Galbraith;  Manuel Gloor;  Yadvinder Malhi;  Shin-Ichiro Aiba;  Miguel N. Alexiades;  Everton C. Almeida;  Edmar Almeida de Oliveira;  Esteban Álvarez Dávila;  Patricia Alvarez Loayza;  Ana Andrade;  Simone Aparecida Vieira;  Luiz E. O. C. Aragão;  Alejandro Araujo-Murakami;  Eric J. M. M. Arets;  Luzmila Arroyo;  Peter Ashton;  Gerardo Aymard C.;  Fabrício B. Baccaro;  Lindsay F. Banin;  Christopher Baraloto;  Plínio Barbosa Camargo;  Jos Barlow;  Jorcely Barroso;  Jean-François Bastin;  Sarah A. Batterman;  Hans Beeckman;  Serge K. Begne;  Amy C. Bennett;  Erika Berenguer;  Nicholas Berry;  Lilian Blanc;  Pascal Boeckx;  Jan Bogaert;  Damien Bonal;  Frans Bongers;  Matt Bradford;  Francis Q. Brearley;  Terry Brncic;  Foster Brown;  Benoit Burban;  José Luís Camargo;  Wendeson Castro;  Carlos Céron;  Sabina Cerruto Ribeiro;  Victor Chama Moscoso;  Jerôme Chave;  Eric Chezeaux;  Connie J. Clark;  Fernanda Coelho de Souza;  Murray Collins;  James A. Comiskey;  Fernando Cornejo Valverde;  Massiel Corrales Medina;  Lola da Costa;  Martin Dančák;  Greta C. Dargie;  Stuart Davies;  Nallaret Davila Cardozo;  Thales de Haulleville;  Marcelo Brilhante de Medeiros;  Jhon del Aguila Pasquel;  Géraldine Derroire;  Anthony Di Fiore;  Jean-Louis Doucet;  Aurélie Dourdain;  Vincent Droissant;  Luisa Fernanda Duque;  Romeo Ekoungoulou;  Fernando Elias;  Terry Erwin;  Adriane Esquivel-Muelbert;  Sophie Fauset;  Joice Ferreira;  Gerardo Flores Llampazo;  Ernest Foli;  Andrew Ford;  Martin Gilpin;  Jefferson S. Hall;  Keith C. Hamer;  Alan C. Hamilton;  David J. Harris;  Terese B. Hart;  Radim Hédl;  Bruno Herault;  Rafael Herrera;  Niro Higuchi;  Annette Hladik;  Eurídice Honorio Coronado;  Isau Huamantupa-Chuquimaco;  Walter Huaraca Huasco;  Kathryn J. Jeffery;  Eliana Jimenez-Rojas;  Michelle Kalamandeen;  Marie Noël Kamdem Djuikouo;  Elizabeth Kearsley;  Ricardo Keichi Umetsu;  Lip Khoon Kho;  Timothy Killeen;  Kanehiro Kitayama;  Bente Klitgaard;  Alexander Koch;  Nicolas Labrière;  William Laurance;  Susan Laurance;  Miguel E. Leal;  Aurora Levesley;  Adriano J. N. Lima;  Janvier Lisingo;  Aline P. Lopes;  Gabriela Lopez-Gonzalez;  Tom Lovejoy;  Jon C. Lovett;  Richard Lowe;  William E. Magnusson;  Jagoba Malumbres-Olarte;  Ângelo Gilberto Manzatto;  Ben Hur Marimon;  Andrew R. Marshall;  Toby Marthews;  Simone Matias de Almeida Reis;  Colin Maycock;  Karina Melgaço;  Casimiro Mendoza;  Faizah Metali;  Vianet Mihindou;  William Milliken;  Edward T. A. Mitchard;  Paulo S. Morandi;  Hannah L. Mossman;  Laszlo Nagy;  Henrique Nascimento;  David Neill;  Reuben Nilus;  Percy Núñez Vargas;  Walter Palacios;  Nadir Pallqui Camacho;  Julie Peacock;  Colin Pendry;  Maria Cristina Peñuela Mora;  Georgia C. Pickavance;  John Pipoly;  Nigel Pitman;  Maureen Playfair;  Lourens Poorter;  John R. Poulsen;  Axel Dalberg Poulsen;  Richard Preziosi;  Adriana Prieto;  Richard B. Primack;  Hirma Ramírez-Angulo;  Jan Reitsma;  Maxime Réjou-Méchain;  Zorayda Restrepo Correa;  Thaiane Rodrigues de Sousa;  Lily Rodriguez Bayona;  Anand Roopsind;  Agustín Rudas;  Ervan Rutishauser;  Kamariah Abu Salim;  Rafael P. Salomão;  Juliana Schietti;  Douglas Sheil;  Richarlly C. Silva;  Javier Silva Espejo;  Camila Silva Valeria;  Marcos Silveira;  Murielle Simo-Droissart;  Marcelo Fragomeni Simon;  James Singh;  Yahn Carlos Soto Shareva;  Clement Stahl;  Juliana Stropp;  Rahayu Sukri;  Terry Sunderland;  Martin Svátek;  Michael D. Swaine;  Varun Swamy;  Hermann Taedoumg;  Joey Talbot;  James Taplin;  David Taylor;  Hans ter Steege;  John Terborgh;  Raquel Thomas;  Sean C. Thomas;  Armando Torres-Lezama;  Peter Umunay;  Luis Valenzuela Gamarra;  Geertje van der Heijden;  Peter van der Hout;  Peter van der Meer;  Mark van Nieuwstadt;  Hans Verbeeck;  Ronald Vernimmen;  Alberto Vicentini;  Ima Célia Guimarães Vieira;  Emilio Vilanova Torre;  Jason Vleminckx;  Vincent Vos;  Ophelia Wang;  Lee J. T. White;  Simon Willcock;  John T. Woods;  Verginia Wortel;  Kenneth Young;  Roderick Zagt;  Lise Zemagho;  Pieter A. Zuidema;  Joeri A. Zwerts;  Oliver L. Phillips
收藏  |  浏览/下载：35/0  |  提交时间：2020/05/25
Processive extrusion of polypeptide loops by a Hsp100 disaggregase (vol 74, pg 212, 2020) 期刊论文
NATURE, 2020
作者:  McBrien, Julia Bergild;  Mavigner, Maud;  Franchitti, Lavinia;  Smith, S. Abigail;  White, Erick;  Tharp, Gregory K.;  Walum, Hasse;  Busman-Suhay, Kathleen;  Aguilera-Sandoval, Christian R.;  Thayer, William O.;  Spagnuolo, Rae Ann;  Kovarova, Martina;  Wahl, Angela;  Cervasi, Barbara;  Margolis, David M.;  Vanderford, Thomas H.;  Carnathan, Diane G.;  Paiardini, Mirko;  Lifson, Jeffrey D.;  Lee, John H.;  Safrit, Jeffrey T.;  Bosinger, Steven E.;  Estes, Jacob D.;  Derdeyn, Cynthia A.;  Garcia, J. Victor;  Kulpa, Deanna A.;  Chahroudi, Ann;  Silvestri, Guido
收藏  |  浏览/下载：22/0  |  提交时间：2020/07/03
Exploring temporality in socio-ecological resilience through experiences of the 2015-16 El Nino across the Tropics 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2019, 55: 1-14
作者:  Whitfield, Stephen;  Beauchamp, Emilie;  Boyd, Doreen S.;  Burslem, David;  Byg, Anja;  Colledge, Francis;  Cutler, Mark E. J.;  Didena, Mengistu;  Dougill, Andrew;  Foody, Giles;  Godbold, Jasmin A.;  Hazenbosch, Mirjam;  Hirons, Mark;  Speranz, Chinwe Ifejika;  Jew, Eleanor;  Lacambra, Carmen;  Mkwambisi, David;  Moges, Awdenegest;  Morel, Alexandra;  Morris, Rebecca;  Novo, Paula;  Rueda, Mario;  Smith, Harriet;  Solan, Martin;  Spencer, Thomas;  Thornton, Ann;  Touza, Julia;  White, Piran C. L.
收藏  |  浏览/下载：17/0  |  提交时间：2019/11/26
Climate change  Variability  Temporal dynamics  Resistance  Perturbations  Societies  Ecosystems  
New NSF policy will stifle innovation 期刊论文
SCIENCE, 2018, 362 (6412) : 297-298
作者:  Alberts, Susan;  Anderson, Rindy;  Ballen, Cissy J.;  Barrick, Jeffrey E.;  Bordenstein, Seth;  Boyd, Sunny K.;  Bracken-Grissom, Heather;  Braun, Christopher B.;  Coppola, David M.;  Cox, Daniel N.;  Crandall, Keith A.;  Cronin, Thomas W.;  Demas, Gregory E.;  Derby, Charles D.;  Edwards, Scott V.;  Eisthen, Heather L.;  Foster, James A.;  Gilbert, Cole;  Halanych, Kenneth M.;  Herculano-Houzel, Suzana;  Hoekstra, Hopi;  Hof, Patrick R.;  Hoke, Kim L.;  Holekamp, Kay E.;  Jarvis, Erich;  Johnsen, Sonke;  Katz, Paul S.;  Kay, Leslie M.;  Kehoe, David M.;  Kelley, Darcy B.;  Kerr, Benjamin;  Ketterson, Ellen;  Kier, William M.;  Koehl, Mimi A. R.;  Last, Robert L.;  Lazazzera, Beth;  Lenski, Richard E.;  Losos, Jonathan B.;  Lutterschmidt, Deborah I.;  Lynch, Michael;  Mahon, Andrew R.;  Martindale, Mark Q.;  Martins, Emilia P.;  McClintock, James B.;  Mesce, Karen A.;  Mukhopadhyay, Suchetana;  Oakley, Todd H.;  Phelps, Steven M.;  Phillips, Richard P.;  Queller, David;  Renn, Suzy C. P.;  Rosvall, Kimberly;  Schweizer, Felix E.;  Shubin, Neil;  Silk, Joan;  Strassmann, Joan E.;  Strausfeld, Nicholas J.;  Strauss, Sharon Y.;  Striedter, Georg;  Swalla, Billie J.;  Tarrant, Ann;  Throop, Heather L.;  Turner, Paul E.;  Voss, S. Randal;  Wake, Marvalee H.;  Wares, John P.;  Webster, Mike;  White, Stephanie A.;  Wilczynski, Walter;  Wray, Greg A.;  Wright, Timothy F.
收藏  |  浏览/下载：21/0  |  提交时间：2019/11/27
Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions 期刊论文
SCIENCE, 2017, 356 (6343) : 1144-1150
作者:  Cole, Kevin P.;  Groh, Jennifer McClary;  Johnson, Martin D.;  Burcham, Christopher L.;  Campbell, Bradley M.;  Diseroad, William D.;  Heller, Michael R.;  Howell, John R.;  Kallman, Neil J.;  Koenig, Thomas M.;  May, Scott A.;  Miller, Richard D.;  Mitchell, David;  Myers, David P.;  Myers, Steven S.;  Phillips, Joseph L.;  Polster, Christopher S.;  White, Timothy D.;  Cashman, Jim;  Hurley, Declan;  Moylan, Robert;  Sheehan, Paul;  Spencer, Richard D.;  Desmond, Kenneth;  Desmond, Paul;  Gowran, Olivia
收藏  |  浏览/下载：14/0  |  提交时间：2019/11/27