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Atmosphere-ocean coupling is critical for tropical cyclones (TC) formation and development. TCs derive their energy from the upper ocean, and the associated TC-ocean interactions can in turn modulate storm evolution. This study assesses the impact of ocean coupling on directly-simulated global TC activity in the high-resolution "TC-permitting" Community Earth System Model (CESM). Model-simulated global TC activity is evaluated in a 30-year fully-coupled CESM simulation (CPL), in which the 0.25 degrees atmosphere component is coupled to the nominal 1 degrees dynamic ocean ( with 0.27 degrees horizontal grid spacing in the tropics). An atmosphere-only simulation (ATM) is branched from CPL, with sea surface temperature (SST) specified from CPL, which we use to isolate the effect of ocean coupling on TC activity. We find that the two-way ocean coupling can affect global TC frequency, geographical distribution, storm intensity, and interannual variability. ATM on average simulates 27% more major TC events than CPL globally, and the TC power dissipation is higher than CPL poleward of 12 degrees latitude in both hemispheres. The lack of negative SST feedbacks in ATM allows TCs to have a longer intensification period and reach the maximum intensity at a higher latitude. In CPL, TC interannual variability is heavily influenced by El Nino/La Nina events. This relationship can be captured in ATM under strong events but is less predictable during weak and neutral years. Results help to better understand the connections and feedbacks linking air-sea coupling, tropical variability, and the directly simulated TC activity within the high- resolution Earth System Models.