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DOI | 10.1126/science.aag2599 |
Layer-specific modulation of neocortical dendritic inhibition during active wakefulness | |
Munoz, William1,2; Tremblay, Robin1,2; Levenstein, Daniel1,2,3; Rudy, Bernardo1,2,4 | |
2017-03-03 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6328页码:954-958 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | gamma-Aminobutyric acid (GABA) ergic inputs are strategically positioned to gate synaptic integration along the dendritic arbor of pyramidal cells. However, their spatiotemporal dynamics during behavior are poorly understood. Using an optical-tagging electrophysiological approach to record and label somatostatin-expressing (Sst) interneurons (GABAergic neurons specialized for dendritic inhibition), we discovered a layer-specific modulation of their activity in behaving mice. Sst interneuron subtypes, residing in different cortical layers and innervating complementary laminar domains, exhibited opposite activity changes during transitions to active wakefulness. The relative weight of vasoactive intestinal peptide-expressing (Vip) interneuron-mediated inhibition of distinct Sst interneurons and cholinergic modulation determined their in vivo activity. These results reveal a state-dependent laminar influence of Sst interneuron-mediated inhibition, with implications for the compartmentalized regulation of dendritic signaling in the mammalian neocortex. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000395181700040 |
WOS关键词 | BARREL CORTEX ; GABAERGIC INTERNEURONS ; CELLULAR MECHANISM ; PYRAMIDAL NEURONS ; VISUAL-CORTEX ; ORGANIZATION ; INTEGRATION ; CIRCUITS ; DYNAMICS ; THALAMUS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195549 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.NYU, Sch Med, Inst Neurosci, 550 First Ave, New York, NY 10016 USA; 2.NYU, Sch Med, Dept Neurosci & Physiol, 550 First Ave, New York, NY 10016 USA; 3.NYU, Ctr Neural Sci, 4 Washington Pl, New York, NY 10003 USA; 4.NYU, Sch Med, Dept Anesthesiol Perioperat Care & Pain Med, 550 First Ave, New York, NY 10016 USA |
推荐引用方式 GB/T 7714 | Munoz, William,Tremblay, Robin,Levenstein, Daniel,et al. Layer-specific modulation of neocortical dendritic inhibition during active wakefulness[J]. SCIENCE,2017,355(6328):954-958. |
APA | Munoz, William,Tremblay, Robin,Levenstein, Daniel,&Rudy, Bernardo.(2017).Layer-specific modulation of neocortical dendritic inhibition during active wakefulness.SCIENCE,355(6328),954-958. |
MLA | Munoz, William,et al."Layer-specific modulation of neocortical dendritic inhibition during active wakefulness".SCIENCE 355.6328(2017):954-958. |
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