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DOI | 10.1126/science.aal3753 |
Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla | |
Furlan, Alessandro1; Dyachuk, Vyacheslav2,3,4; Kastriti, Maria Eleni5; Calvo-Enrique, Laura1; Abdo, Hind1; Hadjab, Saida2; Chontorotzea, Tatiana5; Akkuratova, Natalia6,7; Usoskin, Dmitry1; Kamenev, Dmitry2; Petersen, Julian5,8; Sunadome, Kazunori5; Memic, Fatima1; Marklund, Ulrika1; Fried, Kaj2; Topilko, Piotr9; Lallemend, Francois2; Kharchenko, Peter V.10; Ernfors, Patrik1; Adameyko, Igor5,8 | |
2017-07-07 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6346页码:46-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; Russia; Austria; France; USA |
英文摘要 | Adrenaline is a fundamental circulating hormone for bodily responses to internal and external stressors. Chromaffin cells of the adrenal medulla (AM) represent the main neuroendocrine adrenergic component and are believed to differentiate from neural crest cells. We demonstrate that large numbers of chromaffin cells arise from peripheral glial stem cells, termed Schwann cell precursors (SCPs). SCPs migrate along the visceral motor nerve to the vicinity of the forming adrenal gland, where they detach from the nerve and form postsynaptic neuroendocrine chromaffin cells. An intricate molecular logic drives two sequential phases of gene expression, one unique for a distinct transient cellular state and another for cell type specification. Subsequently, these programs down-regulate SCP-gene and up-regulate chromaffin cell-gene networks. The AM forms through limited cell expansion and requires the recruitment of numerous SCPs. Thus, peripheral nerves serve as a stem cell niche for neuroendocrine system development. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000423900600001 |
WOS关键词 | ENTERIC NERVOUS-SYSTEM ; NEURAL CREST ; STEM-CELLS ; CHROMAFFIN CELLS ; PARASYMPATHETIC NEURONS ; SYMPATHETIC NEURONS ; SCHWANN-CELLS ; DIFFERENTIATION ; RECEPTOR ; ORIGIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196401 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Karolinska Inst, Dept Med Biochem & Biophys, Unit Mol Neurobiol, S-17177 Stockholm, Sweden; 2.Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden; 3.Russian Acad Sci, Far Eastern Branch, Natl Sci Ctr Marine Biol, Vladivostok 690041, Russia; 4.ITMO Univ, Dept Nanophoton & Metamat, St Petersburg 197101, Russia; 5.Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden; 6.Skolkovo Inst Sci & Technol, Moscow 143005, Russia; 7.St Petersburg State Univ, Inst Translat Biomed, St Petersburg 199034, Russia; 8.Med Univ Vienna, Ctr Brain Res, A-1090 Vienna, Austria; 9.Ecole Normale Super, CNRS UMR 8197, Inst Biol Ecole Normale Super, INSERM U1024, 46 Rue Ulm, F-75005 Paris, France; 10.Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Furlan, Alessandro,Dyachuk, Vyacheslav,Kastriti, Maria Eleni,et al. Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla[J]. SCIENCE,2017,357(6346):46-+. |
APA | Furlan, Alessandro.,Dyachuk, Vyacheslav.,Kastriti, Maria Eleni.,Calvo-Enrique, Laura.,Abdo, Hind.,...&Adameyko, Igor.(2017).Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.SCIENCE,357(6346),46-+. |
MLA | Furlan, Alessandro,et al."Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla".SCIENCE 357.6346(2017):46-+. |
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