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DOI | 10.1126/science.aan0365 |
Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death | |
Shlezinger, Neta1; Irmer, Henriette2,3; Dhingra, Sourabh4; Beattie, Sarah R.4; Cramer, Robert A.4; Braus, Gerhard H.2,3; Sharon, Amir5; Hohl, Tobias M.1,6 | |
2017-09-08 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6355页码:1037-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany; Israel |
英文摘要 | Humans inhale mold conidia daily and typically experience lifelong asymptomatic clearance. Conidial germination into tissue-invasive hyphae can occur in individuals with defects in myeloid function, although the mechanism of myeloid cell-mediated immune surveillance remains unclear. By monitoring fungal physiology in vivo, we demonstrate that lung neutrophils trigger programmed cell death with apoptosis-like features in Aspergillus fumigatus conidia, the most prevalent human mold pathogen. An antiapoptotic protein, AfBIR1, opposes this process by inhibiting fungal caspase activation and DNA fragmentation in the murine lung. Genetic and pharmacologic studies indicate that AfBIR1 expression and activity underlie conidial susceptibility to NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase-dependent killing and, in turn, host susceptibility to invasive aspergillosis. Immune surveillance exploits a fungal apoptosis-like programmed cell death pathway to maintain sterilizing immunity in the lung. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000409455700044 |
WOS关键词 | INFECTION ; SURVIVIN ; ASPERGILLOSIS ; INHIBITOR ; FAMILY ; GENES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196822 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Mem Sloan Kettering Canc Ctr, Dept Med, Infect Dis Serv, New York, NY 10065 USA; 2.Univ Gottingen, Inst Microbiol & Genet, Dept Mol Microbiol & Genet, D-37077 Gottingen, Germany; 3.Univ Gottingen, Gottingen Ctr Mol Biosci, D-37077 Gottingen, Germany; 4.Geisel Sch Med Dartmouth, Dept Microbiol & Immunol, Hanover, NH 03755 USA; 5.Tel Aviv Univ, Dept Mol Biol & Ecol Plants, IL-69978 Tel Aviv, Israel; 6.Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Immunol Program, New York, NY 10065 USA |
推荐引用方式 GB/T 7714 | Shlezinger, Neta,Irmer, Henriette,Dhingra, Sourabh,et al. Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death[J]. SCIENCE,2017,357(6355):1037-+. |
APA | Shlezinger, Neta.,Irmer, Henriette.,Dhingra, Sourabh.,Beattie, Sarah R..,Cramer, Robert A..,...&Hohl, Tobias M..(2017).Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death.SCIENCE,357(6355),1037-+. |
MLA | Shlezinger, Neta,et al."Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".SCIENCE 357.6355(2017):1037-+. |
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