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DOI | 10.1126/science.aao1583 |
Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling | |
de Araujo, Mariana E. G.1; Naschberger, Andreas2; Fuernrohr, Barbara G.2; Stasyk, Taras1; Dunzendorfer-Matt, Theresia2; Lechner, Stefan2; Welti, Stefan2; Kremser, Leopold3; Shivalingaiah, Giridhar2; Offterdinger, Martin4; Lindner, Herbert H.3; Huber, Lukas A.1,5; Scheffzek, Klaus2 | |
2017-10-20 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6361页码:377-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Austria |
英文摘要 | The LAMTOR [late endosomal and lysosomal adaptor and MAPK (mitogen-activated protein kinase) and mTOR (mechanistic target of rapamycin) activator] complex, also known as "Ragulator," controls the activity of mTOR complex 1 (mTORC1) on the lysosome. The crystal structure of LAMTOR consists of two roadblock/LC7 domain-folded heterodimers wrapped and apparently held together by LAMTOR1, which assembles the complex on lysosomes. In addition, the Rag guanosine triphosphatases (GTPases) associated with the pentamer through their carboxyl-terminal domains, predefining the orientation for interaction with mTORC1. In vitro reconstitution and experiments with site-directed mutagenesis defined the physiological importance of LAMTOR1 in assembling the remaining components to ensure fidelity of mTORC1 signaling. Functional data validated the effect of two short LAMTOR1 amino acid regions in recruitment and stabilization of the Rag GTPases. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413251000045 |
WOS关键词 | RAG GTPASES ; PROTEIN ; RAGULATOR ; TORC1 ; P14 ; ACTIVATION ; ENDOSOMES ; REVEALS ; SLC38A9 ; PATHWAY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197143 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Med Univ Innsbruck, Div Cell Biol, Bioctr, A-6020 Innsbruck, Austria; 2.Med Univ Innsbruck, Div Biol Chem, Bioctr, A-6020 Innsbruck, Austria; 3.Med Univ Innsbruck, Div Clin Biochem, Bioctr, A-6020 Innsbruck, Austria; 4.Med Univ Innsbruck, Div Neurobiochem Bioopt, Bioctr, A-6020 Innsbruck, Austria; 5.Austrian Drug Screening Inst, A-6020 Innsbruck, Austria |
推荐引用方式 GB/T 7714 | de Araujo, Mariana E. G.,Naschberger, Andreas,Fuernrohr, Barbara G.,et al. Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling[J]. SCIENCE,2017,358(6361):377-+. |
APA | de Araujo, Mariana E. G..,Naschberger, Andreas.,Fuernrohr, Barbara G..,Stasyk, Taras.,Dunzendorfer-Matt, Theresia.,...&Scheffzek, Klaus.(2017).Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.SCIENCE,358(6361),377-+. |
MLA | de Araujo, Mariana E. G.,et al."Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling".SCIENCE 358.6361(2017):377-+. |
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