Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation

doi:10.1126/science.aan4526

GSTDTAP > 地球科学

DOI	10.1126/science.aan4526
	Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation
	Atarashi, Koji 1,2; Suda, Wataru 1,3,4; Luo, Chengwei 5,6,7; Kawaguchi, Takaaki 1,2; Motoo, Iori 2; Narushima, Seiko 2; Kiguchi, Yuya 3; Yasuma, Keiko 1; Watanabe, Eiichiro 2; Tanoue, Takeshi 1,2; Thaiss, Christoph A.8; Sato, Mayuko 9; Toyooka, Kiminori 9; Said, Heba S.10; Yamagami, Hirokazu 11; Rice, Scott A.12; Gevers, Dirk 5; Johnson, Ryan C.13; Segre, Julia A.13; Chen, Kong 14; Kolls, Jay K.14; Elinav, Eran 8; Morita, Hidetoshi 15; Xavier, Ramnik J.5,6,7; Hattori, Masahira 3,4; Honda, Kenya 1,2
	2017-10-20
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2017
卷号	358 期号:6361 页码:359-+
文章类型	Article
语种	英语
国家	Japan; USA; Israel; Egypt; Singapore
英文摘要	Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (T(H)1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000413251000041
WOS关键词	ENTEROBACTER-AEROGENES ; KLEBSIELLA-PNEUMONIAE ; GUT MICROBIOME ; CROHNS-DISEASE ; DIVERSITY ; INFECTION ; DIET
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/197155
专题	地球科学资源环境科学气候变化
作者单位	1.Keio Univ, Dept Microbiol & Immunol, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan; 2.RIKEN, Ctr Integrat Med Sci, Tsurumi Ku, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan; 3.Univ Tokyo, Grad Sch Frontier Sci, 5-1-5 Kashiwanoha, Chiba 2778561, Japan; 4.Waseda Univ, Grad Sch Adv Sci & Engn, Cooperat Major Adv Hlth Sci, Tokyo, Japan; 5.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA; 6.Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA; 7.Harvard Med Sch, Boston, MA 02114 USA; 8.Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel; 9.RIKEN, Ctr Sustainable Resource Sci, Tsurumi Ku, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan; 10.Mansoura Univ, Fac Pharm, Dept Microbiol & Immunol, Mansoura 35516, Egypt; 11.Osaka City Univ, Grad Sch Med, Dept Gastroenterol, Osaka, Japan; 12.Nanyang Technol Univ, Sch Biol Sci, Singapore Ctr Environm Life Sci Engn, Singapore, Singapore; 13.NHGRI, Microbial Genom Sect, NIH, Bethesda, MD 20892 USA; 14.Univ Pittsburgh, Sch Med, Dept Pediat, Richard King Mellon Fdn Inst Pediat Res, Pittsburgh, PA 15224 USA; 15.Okayama Univ, Grad Sch Environm & Life Sci, Okayama, Japan
推荐引用方式 GB/T 7714	Atarashi, Koji,Suda, Wataru,Luo, Chengwei,et al. Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation[J]. SCIENCE,2017,358(6361):359-+.
APA	Atarashi, Koji.,Suda, Wataru.,Luo, Chengwei.,Kawaguchi, Takaaki.,Motoo, Iori.,...&Honda, Kenya.(2017).Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation.SCIENCE,358(6361),359-+.
MLA	Atarashi, Koji,et al."Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation".SCIENCE 358.6361(2017):359-+.