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DOI | 10.1126/science.aao4555 |
C1q restrains autoimmunity and viral infection by regulating CD8(+) T cell metabolism | |
Ling, Guang Sheng1; Crawford, Greg1; Buang, Norzawani1; Bartok, Istvan1; Tian, Kunyuan1; Thielens, Nicole M.2; Bally, Isabelle2; Harker, James A.1; Ashton-Rickardt, Philip G.1; Rutschmann, Sophie1; Strid, Jessica1; Botto, Marina1 | |
2018-05-04 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6388页码:558-563 |
文章类型 | Article |
语种 | 英语 |
国家 | England; France |
英文摘要 | Deficiency of C1q, the initiator of the complement classical pathway, is associated with the development of systemic lupus erythematosus (SLE). Explaining this association in terms of abnormalities in the classical pathway alone remains problematic because C3 deficiency does not predispose to SLE. Here, using a mouse model of SLE, we demonstrate that C1q, but not C3, restrains the response to self-antigens by modulating the mitochondrial metabolism of CD8(+) T cells, which can themselves propagate autoimmunity. C1q deficiency also triggers an exuberant effector CD8(+) T cell response to chronic viral infection leading to lethal immunopathology. These data establish a link between C1q and CD8(+) T cell metabolism and may explain how C1q protects against lupus, with implications for the role of viral infections in the perpetuation of autoimmunity. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000431351500051 |
WOS关键词 | SYSTEMIC-LUPUS-ERYTHEMATOSUS ; GRANZYME-B ; COMPLEMENT ; DISEASE ; IMMUNITY ; MICE ; INFLAMMATION ; LYMPHOCYTES ; PROGNOSIS ; MOLECULE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198578 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Imperial Coll London, Fac Med, London W12 0NN, England; 2.Univ Grenoble Alpes, CEA Grenoble, CNRS, IBS, F-38000 Grenoble, France |
推荐引用方式 GB/T 7714 | Ling, Guang Sheng,Crawford, Greg,Buang, Norzawani,et al. C1q restrains autoimmunity and viral infection by regulating CD8(+) T cell metabolism[J]. SCIENCE,2018,360(6388):558-563. |
APA | Ling, Guang Sheng.,Crawford, Greg.,Buang, Norzawani.,Bartok, Istvan.,Tian, Kunyuan.,...&Botto, Marina.(2018).C1q restrains autoimmunity and viral infection by regulating CD8(+) T cell metabolism.SCIENCE,360(6388),558-563. |
MLA | Ling, Guang Sheng,et al."C1q restrains autoimmunity and viral infection by regulating CD8(+) T cell metabolism".SCIENCE 360.6388(2018):558-563. |
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