Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat1699 |
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors | |
Young, Matthew D.1; Mitchell, Thomas J.1,2,3; Braga, Felipe A. Vieira1; Tran, Maxine G. B.4,5; Stewart, Benjamin J.6; Ferdinand, John R.6; Collord, Grace1,2,7; Botting, Rachel A.8; Popescu, Dorin-Mirel8; Loudon, Kevin W.6; Vento-Tormo, Roser1; Stephenson, Emily8; Cagan, Alex1; Farndon, Sarah J.1,9,10; Velasco-Herrera, Martin Del Castillo1; Guzzo, Charlotte1; Richoz, Nathan6; Mamanova, Lira1; Aho, Tevita2; Armitage, James N.3; Riddick, Antony C. P.3; Mushtaq, Imran9; Farrell, Stephen2; Rampling, Dyanne9; Nicholson, James2,7; Filby, Andrew8; Burge, Johanna2; Lisgo, Steven11; Maxwell, Patrick H.12; Lindsay, Susan11; Warren, Anne Y.2; Stewart, Grant D.2,3; Sebire, Neil9,10; Coleman, Nicholas2,13; Haniffa, Muzlifah8,14; Teichmann, Sarah A.1; Clatworthy, Menna2,6; Behjati, Sam1,2,7 | |
2018-08-10 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6402页码:594-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England |
英文摘要 | Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal tumors and normal tissue from fetal, pediatric, and adult kidneys. We matched childhood Wilms tumor with specific fetal cell types. thus providing evidence for the hypothesis that Wilms tumor cells are aberrant fetal cells. In adult renal cell carcinoma, we identified a canonical cancer transcriptome that matched a little-known subtype of proximal convoluted tubular cell. Analyses of the tumor composition defined cancer-associated normal cells and delineated a complex vascular endothelial growth factor (VEGF) signaling circuit. Our findings reveal the precise cellular identities and compositions of human kidney tumors. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000441202700036 |
WOS关键词 | WILMS-TUMOR ; EXPRESSION ; CARCINOMA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199333 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Wellcome Sanger Inst, Hinxton CB10 1SA, England; 2.Cambridge Univ Hosp NHS Fdn Trust, Cambridge CB2 0QQ, England; 3.Univ Cambridge, Dept Surg, Cambridge CB2 0QQ, England; 4.Royal Free Hosp, UCL Div Surg & Intervent Sci, London NW3 2PS, England; 5.Royal Free Hosp, Specialist Ctr Kidney Canc, London NW3 2PS, England; 6.Univ Cambridge, Dept Med, Mol Immun Unit, MRC Lab Mol Biol, Cambridge CB2 0QQ, England; 7.Univ Cambridge, Dept Paediat, Cambridge CB2 0QQ, England; 8.Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England; 9.Great Ormond St Hosp Children NHS Fdn Trust, London WC1N 3JH, England; 10.UCL Great Ormond St Hosp, Inst Child Hlth, London WC1N 1E, England; 11.Newcastle Univ, Inst Genet Med, Human Dev Biol Resource, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England; 12.Univ Cambridge, Cambridge Inst Med Res, Cambridge CB2 0XY, England; 13.Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England; 14.Newcastle Hosp NHS Fdn Trust, Royal Victoria Infirm, Dept Dermatol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England |
推荐引用方式 GB/T 7714 | Young, Matthew D.,Mitchell, Thomas J.,Braga, Felipe A. Vieira,et al. Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors[J]. SCIENCE,2018,361(6402):594-+. |
APA | Young, Matthew D..,Mitchell, Thomas J..,Braga, Felipe A. Vieira.,Tran, Maxine G. B..,Stewart, Benjamin J..,...&Behjati, Sam.(2018).Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.SCIENCE,361(6402),594-+. |
MLA | Young, Matthew D.,et al."Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors".SCIENCE 361.6402(2018):594-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论