The opium poppy genome and morphinan production

doi:10.1126/science.aat4096

GSTDTAP > 地球科学

DOI	10.1126/science.aat4096
	The opium poppy genome and morphinan production
	Guo, Li 1,2,3; Winzer, Thilo 4; Yang, Xiaofei 1,5; Li, Yi 4; Ning, Zemin 6; He, Zhesi 4; Teodor, Roxana 4; Lu, Ying 7; Bowser, Tim A.8; Graham, Ian A.4; Ye, Kai 1,2,3,9
	2018-10-19
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2018
卷号	362 期号:6412 页码:343-+
文章类型	Article
语种	英语
国家	Peoples R China; England; Australia
英文摘要	Morphinan-based painkillers are derived from opium poppy. We report a draft of the opium poppy genome, with 2.72Gb assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77Mb and 204Mb, respectively. Synteny analysis suggests a whole genome duplication at approximately 7.8 million years ago (MYA) and ancient segmental or whole genome duplication(s) that occurred before the Papaveraceae-Ranunculaceae divergence 110 MYA. Syntenic blocks representative of phthalideisoquinoline and morphinan components of a benzylisoquinoline alkaloid cluster of 15 genes provides insight into how it evolved. Paralog analysis identified P450 and oxidoreductase genes that combined to form the STORR gene fusion essential for morphinan biosynthesis in opium poppy. Thus gene duplication, rearrangement and fusion events have led to evolution of specialized metabolic products in opium poppy.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000454632300001
WOS关键词	MULTIPLE SEQUENCE ALIGNMENT ; PROVIDES INSIGHTS ; IDENTIFICATION ; ANNOTATION ; TRANSCRIPTOME ; BIOSYNTHESIS ; EVOLUTION ; TOOLKIT ; FUSION ; TIME
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/199890
专题	地球科学资源环境科学气候变化
作者单位	1.Xi An Jiao Tong Univ, Sch Elect & Informat Engn, MOE Key Lab Intelligent Networks & Networks Secur, Xian 710049, Peoples R China; 2.Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian 710061, Peoples R China; 3.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Xian 710049, Peoples R China; 4.Univ York, Dept Biol, Ctr Novel Agr Prod, York YO10 5YW, N Yorkshire, England; 5.Xi An Jiao Tong Univ, Sch Elect & Informat Engn, Dept Comp Sci, Xian 710049, Peoples R China; 6.Wellcome Sanger Inst, Wellcome Genome Campus, Cambridge CB10 1SA, England; 7.Shanghai Ocean Univ, Shanghai 201306, Peoples R China; 8.Sun Pharmaceut Ind Australia Pty Ltd, Princes Highway, Port Fairy, Vic 3284, Australia; 9.Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Guo, Li,Winzer, Thilo,Yang, Xiaofei,et al. The opium poppy genome and morphinan production[J]. SCIENCE,2018,362(6412):343-+.
APA	Guo, Li.,Winzer, Thilo.,Yang, Xiaofei.,Li, Yi.,Ning, Zemin.,...&Ye, Kai.(2018).The opium poppy genome and morphinan production.SCIENCE,362(6412),343-+.
MLA	Guo, Li,et al."The opium poppy genome and morphinan production".SCIENCE 362.6412(2018):343-+.