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DOI | 10.1126/science.aat2952 |
Nested sequences of hippocampal assemblies during behavior support subsequent sleep replay | |
Drieu, Celine; Todorova, Ralitsa; Zugaro, Michael | |
2018-11-09 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6415页码:675-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | Consolidation of spatial and episodic memories is thought to rely on replay of neuronal activity sequences during sleep. However, the network dynamics underlying the initial storage of memories during wakefulness have never been tested. Although slow, behavioral time scale sequences have been claimed to sustain sequential memory formation, fast ("theta") time scale sequences, nested within slow sequences, could be instrumental. We found that in rats traveling passively on a model train, place cells formed behavioral time scale sequences but theta sequences were degraded, resulting in impaired subsequent sleep replay. In contrast, when the rats actively ran on a treadmill while being transported on the train, place cells generated clear theta sequences and accurate trajectory replay during sleep. Our results support the view that nested sequences underlie the initial formation of memory traces subsequently consolidated during sleep. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000450474500038 |
WOS关键词 | THETA-PHASE PRECESSION ; CELL ASSEMBLIES ; PLACE CELLS ; EXPERIENCE ; MEMORY ; DYNAMICS ; MODEL ; RAT ; CA1 ; OSCILLATIONS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200035 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | PSL Res Univ, CNRS, INSERM, CIRB,Coll France, Paris, France |
推荐引用方式 GB/T 7714 | Drieu, Celine,Todorova, Ralitsa,Zugaro, Michael. Nested sequences of hippocampal assemblies during behavior support subsequent sleep replay[J]. SCIENCE,2018,362(6415):675-+. |
APA | Drieu, Celine,Todorova, Ralitsa,&Zugaro, Michael.(2018).Nested sequences of hippocampal assemblies during behavior support subsequent sleep replay.SCIENCE,362(6415),675-+. |
MLA | Drieu, Celine,et al."Nested sequences of hippocampal assemblies during behavior support subsequent sleep replay".SCIENCE 362.6415(2018):675-+. |
条目包含的文件 | 条目无相关文件。 |
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