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DOI | 10.1126/science.aav9011 |
Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8 | |
Herguedas, Beatriz1; Watson, Jake F.1; Ho, Hinze1; Cais, Ondrej1; Garcia-Nafria, Javier2; Greger, Ingo H.1 | |
2019-04-26 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6438页码:352-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England |
英文摘要 | AMPA-type glutamate receptors (AMPARs) mediate excitatory neurotransmission and are central regulators of synaptic plasticity, a molecular mechanism underlying learning and memory. Although AMPARs act predominantly as heteromers, structural studies have focused on homomeric assemblies. Here, we present a cryo-electron microscopy structure of the heteromeric GluA1/2 receptor associated with two transmembrane AMPAR regulatory protein (TARP) gamma 8 auxiliary subunits, the principal AMPAR complex at hippocampal synapses. Within the receptor, the core subunits arrange to give the GluA2 subunit dominant control of gating. This structure reveals the geometry of the Q/R site that controls calcium flux, suggests association of TARP-stabilized lipids, and demonstrates that the extracellular loop of gamma 8 modulates gating by selectively interacting with the GluA2 ligand-binding domain. Collectively, this structure provides a blueprint for deciphering the signal transduction mechanisms of synaptic AMPARs. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000465643400037 |
WOS关键词 | HIPPOCAMPAL SYNAPTIC PLASTICITY ; GLUTAMATE-RECEPTOR ; CRYSTAL-STRUCTURE ; POINT MUTATION ; STRUCTURAL DETERMINANTS ; KINETIC-PROPERTIES ; TERMINAL DOMAIN ; ION FLOW ; ACTIVATION ; PORE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201294 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Med Res Council MRC Lab Mol Biol, Neurobiol Div, Cambridge, England; 2.MRC Lab Mol Biol, Struct Studies Div, Cambridge, England |
推荐引用方式 GB/T 7714 | Herguedas, Beatriz,Watson, Jake F.,Ho, Hinze,et al. Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8[J]. SCIENCE,2019,364(6438):352-+. |
APA | Herguedas, Beatriz,Watson, Jake F.,Ho, Hinze,Cais, Ondrej,Garcia-Nafria, Javier,&Greger, Ingo H..(2019).Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8.SCIENCE,364(6438),352-+. |
MLA | Herguedas, Beatriz,et al."Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8".SCIENCE 364.6438(2019):352-+. |
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