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DOI | 10.1126/science.aan0925 |
Cell competition during reprogramming gives rise to dominant clones | |
Shakiba, Nika1; Fahmy, Ahmed2; Jayakumaran, Gowtham2,3,16; McGibbon, Sophie4; David, Laurent5,6,7; Trcka, Daniel3; Elbaz, Judith3; Puri, Mira C.3,8; Nagy, Andras3,9,10,11; van der Kooy, Derek2,12; Goyal, Sidhartha1,4; Wrana, Jeffrey L.2,3; Zandstra, Peter W.1,12,13,14,15 | |
2019-04-26 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6438页码:354-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Canada; France; Australia; USA |
英文摘要 | The ability to generate induced pluripotent stem cells from differentiated cell types has enabled researchers to engineer cell states. Although studies have identified molecular networks that reprogram cells to pluripotency, the cellular dynamics of these processes remain poorly understood. Here, by combining cellular barcoding, mathematical modeling, and lineage tracing approaches, we demonstrate that reprogramming dynamics in heterogeneous populations are driven by dominant "elite" clones. Clones arise a priori from a population of poised mouse embryonic fibroblasts derived from Wnt1-expressing cells that may represent a neural crest-derived population. This work highlights the importance of cellular dynamics in fate programming outcomes and uncovers cell competition as a mechanism by which cells with eliteness emerge to occupy and dominate the reprogramming niche. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000465643400039 |
WOS关键词 | NEURAL CREST ; SOMATIC-CELLS ; STEM-CELLS ; PLURIPOTENCY ; FIBROBLASTS ; ELIMINATE ; ROUTES ; FATE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201305 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Toronto, Inst Biomat & Biomed Engn IBBME, Toronto, ON M5S 3E1, Canada; 2.Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada; 3.Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada; 4.Univ Toronto, Dept Phys, Toronto, ON M5S 1A7, Canada; 5.Univ Nantes, CHU Nantes, SFR SANTE, iPSC Core Facil,INSERM,CNRS, Nantes, France; 6.Univ Nantes, CRTI, INSERM, Nantes, France; 7.CHU Nantes, ITUN, Nantes, France; 8.Univ Toronto, Dept Med Biophys, Toronto, ON M5T 3H7, Canada; 9.Univ Toronto, Dept Obstet & Gynecol, Toronto, ON M5G 1E2, Canada; 10.Univ Toronto, Inst Med Sci, Toronto, ON M5T 3H7, Canada; 11.Monash Univ, Australian Regenerat Med Inst, Melbourne, Vic, Australia; 12.Univ Toronto, Donnelly Ctr Cellular & Biomol Res CCBR, Toronto, ON M5S 3E1, Canada; 13.Univ British Columbia, Sch Biomed Engn, Vancouver, BC V6T 1Z3, Canada; 14.Univ British Columbia, Biomed Res Ctr, Vancouver, BC V6T 1Z3, Canada; 15.Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada; 16.Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA |
推荐引用方式 GB/T 7714 | Shakiba, Nika,Fahmy, Ahmed,Jayakumaran, Gowtham,et al. Cell competition during reprogramming gives rise to dominant clones[J]. SCIENCE,2019,364(6438):354-+. |
APA | Shakiba, Nika.,Fahmy, Ahmed.,Jayakumaran, Gowtham.,McGibbon, Sophie.,David, Laurent.,...&Zandstra, Peter W..(2019).Cell competition during reprogramming gives rise to dominant clones.SCIENCE,364(6438),354-+. |
MLA | Shakiba, Nika,et al."Cell competition during reprogramming gives rise to dominant clones".SCIENCE 364.6438(2019):354-+. |
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