Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw6985 |
Cancer modeling meets human organoid technology | |
Tuveson, David1,2; Clevers, Hans3,4,5 | |
2019-06-07 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6444页码:952-955 |
文章类型 | Review |
语种 | 英语 |
国家 | USA; Netherlands |
英文摘要 | Organoids are microscopic self-organizing, three-dimensional structures that are grown from stem cells in vitro. They recapitulate many structural and functional aspects of their in vivo counterpart organs. This versatile technology has led to the development of many novel human cancer models. It is now possible to create indefinitely expanding organoids starting from tumor tissue of individuals suffering from a range of carcinomas. Alternatively, CRISPR-based gene modification allows the engineering of organoid models of cancer through the introduction of any combination of cancer gene alterations to normal organoids. When combined with immune cells and fibroblasts, tumor organoids become models for the cancer microenvironment enabling immune-oncology applications. Emerging evidence indicates that organoids can be used to accurately predict drug responses in a personalized treatment setting. Here, we review the current state and future prospects of the rapidly evolving tumor organoid field. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000482914100047 |
WOS关键词 | STEM-CELLS ; IN-VITRO ; HUMAN COLON ; EXPANSION ; CULTURES ; BIOBANK |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201592 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA; 2.Lustgarten Fdn Pancreat Canc Res Lab, Cold Spring Harbor, NY 11724 USA; 3.Royal Netherlands Acad Arts & Sci, Oncode Inst, NL-3584 Utrecht, Netherlands; 4.Royal Netherlands Acad Arts & Sci, Hubrecht Inst, NL-3584 Utrecht, Netherlands; 5.Univ Med Ctr Utrecht, NL-3584 Utrecht, Netherlands |
推荐引用方式 GB/T 7714 | Tuveson, David,Clevers, Hans. Cancer modeling meets human organoid technology[J]. SCIENCE,2019,364(6444):952-955. |
APA | Tuveson, David,&Clevers, Hans.(2019).Cancer modeling meets human organoid technology.SCIENCE,364(6444),952-955. |
MLA | Tuveson, David,et al."Cancer modeling meets human organoid technology".SCIENCE 364.6444(2019):952-955. |
条目包含的文件 | 条目无相关文件。 |
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