GSTDTAP  > 地球科学
DOI10.1126/science.aaw6985
Cancer modeling meets human organoid technology
Tuveson, David1,2; Clevers, Hans3,4,5
2019-06-07
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号364期号:6444页码:952-955
文章类型Review
语种英语
国家USA; Netherlands
英文摘要

Organoids are microscopic self-organizing, three-dimensional structures that are grown from stem cells in vitro. They recapitulate many structural and functional aspects of their in vivo counterpart organs. This versatile technology has led to the development of many novel human cancer models. It is now possible to create indefinitely expanding organoids starting from tumor tissue of individuals suffering from a range of carcinomas. Alternatively, CRISPR-based gene modification allows the engineering of organoid models of cancer through the introduction of any combination of cancer gene alterations to normal organoids. When combined with immune cells and fibroblasts, tumor organoids become models for the cancer microenvironment enabling immune-oncology applications. Emerging evidence indicates that organoids can be used to accurately predict drug responses in a personalized treatment setting. Here, we review the current state and future prospects of the rapidly evolving tumor organoid field.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000482914100047
WOS关键词STEM-CELLS ; IN-VITRO ; HUMAN COLON ; EXPANSION ; CULTURES ; BIOBANK
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/201592
专题地球科学
资源环境科学
气候变化
作者单位1.Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA;
2.Lustgarten Fdn Pancreat Canc Res Lab, Cold Spring Harbor, NY 11724 USA;
3.Royal Netherlands Acad Arts & Sci, Oncode Inst, NL-3584 Utrecht, Netherlands;
4.Royal Netherlands Acad Arts & Sci, Hubrecht Inst, NL-3584 Utrecht, Netherlands;
5.Univ Med Ctr Utrecht, NL-3584 Utrecht, Netherlands
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GB/T 7714
Tuveson, David,Clevers, Hans. Cancer modeling meets human organoid technology[J]. SCIENCE,2019,364(6444):952-955.
APA Tuveson, David,&Clevers, Hans.(2019).Cancer modeling meets human organoid technology.SCIENCE,364(6444),952-955.
MLA Tuveson, David,et al."Cancer modeling meets human organoid technology".SCIENCE 364.6444(2019):952-955.
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