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DOI | 10.1126/science.aax0758 |
Long-duration hippocampal sharp wave ripples improve memory | |
Fernandez-Ruiz, Antonio1; Oliva, Azahara1,2,3; de Oliveira, Eliezyer Fermino1,4; Rocha-Almeida, Florbela1,5; Tingley, David1; Buzsaki, Gyorgy1,6 | |
2019-06-14 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6445页码:1082-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Brazil; Spain |
英文摘要 | Hippocampal sharp wave ripples (SPW-Rs) have been hypothesized as a mechanism for memory consolidation and action planning. The duration of ripples shows a skewed distribution with a minority of long-duration events. We discovered that long-duration ripples are increased in situations demanding memory in rats. Prolongation of spontaneously occurring ripples by optogenetic stimulation, but not randomly induced ripples, increased memory during maze learning. The neuronal content of randomly induced ripples was similar to short-duration spontaneous ripples and contained little spatial information. The spike content of the optogenetically prolonged ripples was biased by the ongoing, naturally initiated neuronal sequences. Prolonged ripples recruited new neurons that represented either arm of the maze. Long-duration hippocampal SPW-Rs replaying large parts of planned routes are critical for memory. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000471306700044 |
WOS关键词 | LOCAL-FIELD POTENTIALS ; GAMMA FREQUENCY ; SEQUENCES ; REPLAY ; REACTIVATION ; INPUT ; CA1 ; OSCILLATIONS ; GENERATION ; DYNAMICS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201645 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.NYU, Neurosci Inst, 550 1St Ave, New York, NY 10016 USA; 2.Columbia Univ, Dept Neurosci, New York, NY 10027 USA; 3.Columbia Univ, Zuckerman Mind Brain Behav Inst, New York, NY 10027 USA; 4.Univ Fed ABC, Ctr Math Comp & Cognit, Sao Paulo, Brazil; 5.Univ Pablo de Olavide, Div Neurosci, Seville 41013, Spain; 6.NYU, Ctr Neural Sci, 550 1St Ave, New York, NY 10016 USA |
推荐引用方式 GB/T 7714 | Fernandez-Ruiz, Antonio,Oliva, Azahara,de Oliveira, Eliezyer Fermino,et al. Long-duration hippocampal sharp wave ripples improve memory[J]. SCIENCE,2019,364(6445):1082-+. |
APA | Fernandez-Ruiz, Antonio,Oliva, Azahara,de Oliveira, Eliezyer Fermino,Rocha-Almeida, Florbela,Tingley, David,&Buzsaki, Gyorgy.(2019).Long-duration hippocampal sharp wave ripples improve memory.SCIENCE,364(6445),1082-+. |
MLA | Fernandez-Ruiz, Antonio,et al."Long-duration hippocampal sharp wave ripples improve memory".SCIENCE 364.6445(2019):1082-+. |
条目包含的文件 | 条目无相关文件。 |
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