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DOI | 10.1126/science.aaw7479 |
Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis | |
Ansaldo, Eduard1; Slayden, Leianna C.1; Ching, Krystal L.1,9; Koch, Meghan A.1,10; Wolf, Natalie K.1; Plichta, Damian R.2; Brown, Eric M.2; Graham, Daniel B.2,3,4,5,6; Xavier, Ramnik J.2,3,4,5,6; Moon, James J.7,8; Barton, Gregory M.1 | |
2019-06-21 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6446页码:1179-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Intestinal adaptive immune responses influence host health, yet only a few intestinal bacteria species that induce cognate adaptive immune responses during homeostasis have been identified. Here, we show that Akkermansia muciniphila, an intestinal bacterium associated with systemic effects on host metabolism and PD-1 checkpoint immunotherapy, induces immunoglobulin G1 (IgG1) antibodies and antigen-specific T cell responses in mice. Unlike previously characterized mucosal responses, T cell responses to A. muciniphila are limited to T follicular helper cells in a gnotobiotic setting, without appreciable induction of other T helper fates or migration to the lamina propria. However, A. muciniphila-specific responses are context dependent and adopt other fates in conventional mice. These findings suggest that, during homeostasis, contextual signals influence T cell responses to the microbiota and modulate host immune function. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000472175100041 |
WOS关键词 | CELL RESPONSES ; IGA RESPONSES ; T(H)17 CELLS ; T-CELLS ; BACTERIA ; MICROBIOTA ; COLONIZATION ; EXPRESSION ; INFECTION ; FOXP3(+) |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201700 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Berkeley, Dept Mol & Cell Biol, Div Immunol & Pathogenesis, 229 Stanley Hall, Berkeley, CA 94720 USA; 2.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA; 3.Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA; 4.Harvard Med Sch, Boston, MA 02115 USA; 5.Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA; 6.MIT, Ctr Microbiome Informat & Therapeut, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 7.Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA; 8.Massachusetts Gen Hosp, Div Pulm & Crit Care Med, Boston, MA 02114 USA; 9.NYU, Sch Med, Sackler Inst Grad Biomed Sci, New York, NY USA; 10.Fred Hutchinson Canc Res Ctr, Basic Sci Div, 1124 Columbia St, Seattle, WA 98104 USA |
推荐引用方式 GB/T 7714 | Ansaldo, Eduard,Slayden, Leianna C.,Ching, Krystal L.,et al. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis[J]. SCIENCE,2019,364(6446):1179-+. |
APA | Ansaldo, Eduard.,Slayden, Leianna C..,Ching, Krystal L..,Koch, Meghan A..,Wolf, Natalie K..,...&Barton, Gregory M..(2019).Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis.SCIENCE,364(6446),1179-+. |
MLA | Ansaldo, Eduard,et al."Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis".SCIENCE 364.6446(2019):1179-+. |
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