Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aax6648 |
Mapping human cell phenotypes to genotypes with single-cell genomics | |
Camp, J. Gray1; Platt, Randall2; Treutlein, Barbara2 | |
2019-09-27 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 365期号:6460页码:1401-+ |
文章类型 | Review |
语种 | 英语 |
国家 | Switzerland |
英文摘要 | The cumulative activity of all of the body's cells, with their myriad interactions, life histories. and environmental experiences, gives rise to a condition that is distinctly human and specific to each individual. It is an enduring goal to catalog our human cell types, to understand how they develop, how they vary between individuals, and how they fail in disease. Single-cell genomics has revolutionized this endeavor because sequencing-based methods provide a means to quantitatively annotate cell states on the basis of high-information content and high-throughput measurements. Together with advances in stem cell biology and gene editing, we are in the midst of a fascinating journey to understand the cellular phenotypes that compose human bodies and how the human genome is used to build and maintain each cell. Here, we will review recent advances into how single-cell genomics is being used to develop personalized phenotyping strategies that cross subcellular, cellular, and tissue scales to link our genome to our cumulative cellular phenotypes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000488838600037 |
WOS关键词 | HUMAN STEM-CELL ; SELF-ORGANIZATION ; CRISPR ; ORGANOIDS ; SCREENS ; SEQ ; DNA ; TRANSCRIPTION ; TECHNOLOGIES ; GENERATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/202400 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Inst Mol & Clin Ophthalmol Basel, Basel, Switzerland; 2.Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland |
推荐引用方式 GB/T 7714 | Camp, J. Gray,Platt, Randall,Treutlein, Barbara. Mapping human cell phenotypes to genotypes with single-cell genomics[J]. SCIENCE,2019,365(6460):1401-+. |
APA | Camp, J. Gray,Platt, Randall,&Treutlein, Barbara.(2019).Mapping human cell phenotypes to genotypes with single-cell genomics.SCIENCE,365(6460),1401-+. |
MLA | Camp, J. Gray,et al."Mapping human cell phenotypes to genotypes with single-cell genomics".SCIENCE 365.6460(2019):1401-+. |
条目包含的文件 | 条目无相关文件。 |
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