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DOI | 10.1038/ncomms14087 |
RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family | |
Son, Young-Ok1,2; Kim, Hyo-Eun1,2; Choi, Wan-Su1,2; Chun, Churl-Hong3; Chun, Jang-Soo1,2 | |
2019-01-08 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2019 |
卷号 | 10 |
文章类型 | Article |
语种 | 英语 |
国家 | South Korea |
英文摘要 | Osteoarthritis (OA) is a whole-joint disease characterized by cartilage destruction and other whole-joint pathological changes. There is currently no effective disease-modifying therapy. Here we investigate the post-transcriptional mRNA regulation of OA-modulating proteins in chondrocytes and show that the ZFP36 family member, ZFP36L1, is specifically upregulated in OA chondrocytes and OA cartilage of humans and mice. Adenovirus-mediated over-expression of ZFP36L1 alone in mouse knee-joint tissue does not modulate OA pathogenesis. However, genetic ablation or silencing of Zfp36l1 significantly abrogates experimental OA in mice. Knockdown of Zfp36l1 increases the mRNA expression of two heat shock protein 70 (HSP70) family members, which act as its direct targets. Furthermore, overexpression of HSPA1A in joint tissues protects mice against experimental OA by inhibiting chondrocyte apoptosis. Our results indicate that the RNA-binding protein, ZFP36L1, regulates HSP70 family members that appear to protect against OA pathogenesis by inhibiting chondrocyte apoptosis. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000455102900016 |
WOS关键词 | OXIDE-INDUCED APOPTOSIS ; ZINC-FINGER PROTEIN ; HEAT-SHOCK ; POSTTRANSCRIPTIONAL REGULATION ; GENE-EXPRESSION ; MESSENGER-RNA ; HSP70 ; TTP ; DIFFERENTIATION ; CHONDROCYTES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203169 |
专题 | 资源环境科学 |
作者单位 | 1.Gwangju Inst Sci & Technol, Natl Creat Res Initiat, Ctr Osteoarthrit Pathogenesis, Gwangju 61005, South Korea; 2.Gwangju Inst Sci & Technol, Sch Life Sci, Gwangju 61005, South Korea; 3.Wonkwang Univ, Dept Orthoped Surg, Sch Med, Iksan 54538, South Korea |
推荐引用方式 GB/T 7714 | Son, Young-Ok,Kim, Hyo-Eun,Choi, Wan-Su,et al. RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family[J]. NATURE COMMUNICATIONS,2019,10. |
APA | Son, Young-Ok,Kim, Hyo-Eun,Choi, Wan-Su,Chun, Churl-Hong,&Chun, Jang-Soo.(2019).RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family.NATURE COMMUNICATIONS,10. |
MLA | Son, Young-Ok,et al."RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family".NATURE COMMUNICATIONS 10(2019). |
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