Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells

doi:10.1038/s41467-017-01544-x

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-017-01544-x
	Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells
	Esteve, D.1; Boulet, N.1; Belles, C.1; Zakaroff-Girard, A.1,2; Decaunes, P.1; Briot, A.1; Veeranagouda, Y.3; Didier, M.3; Remaury, A.3; Guillemot, J. C.3; Ledoux, S.4; Dani, C.5; Bouloumie, A.1; Galitzky, J.1
	2019-06-11
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2019
卷号	10
文章类型	Article
语种	英语
国家	France
英文摘要	Human adipose tissue (hAT) is constituted of structural units termed lobules, the organization of which remains to be defined. Here we report that lobules are composed of two extracellular matrix compartments, i.e., septa and stroma, delineating niches of CD45-/CD34+/CD31- progenitor subsets characterized by MSCA1 (ALPL) and CD271 (NGFR) expression. MSCA1+ adipogenic subset is enriched in stroma while septa contains mainly MSCA1-/CD271- and MSCA1-/CD271(high) progenitors. CD271 marks myofibroblast precursors and NGF ligand activation is a molecular relay of TGF beta-induced myofibroblast conversion. In human subcutaneous (SC) and visceral (VS) AT, the progenitor subset repartition is different, modulated by obesity and in favor of adipocyte and myofibroblast fate, respectively. Lobules exhibit depot-specific architecture with marked fibrous septa containing mesothelial-like progenitor cells in VSAT. Thus, the human AT lobule organization in specific progenitor subset domains defines the fat depot intrinsic capacity to remodel and may contribute to obesity-associated cardiometabolic risks.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000470968400009
WOS关键词	NEUROTROPHIN RECEPTOR ; ADIPOCYTE PROGENITORS ; OBESITY ; ACCUMULATION ; WHITE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/203526
专题	资源环境科学
作者单位	1.Univ Toulouse, Inst Metab & Cardiovasc Dis, I2MC, Inserm,UMR 1048,Team 1, BP84225, F-31432 Toulouse 4, France; 2.Inserm, UMR 1048, Cytometry Platform, I2MC,Inst Metab & Cardiovasc Dis, BP84225, F-31432 Toulouse 4, France; 3.Sanofi Aventis Res & Dev Translat Sci, F-91385 Chilly Mazarin, France; 4.Univ Paris Diderot, Louis Mourier Hosp, Ctr Support Obes, F-92700 Colombes, France; 5.Univ Cote dAzur, INSERM, CNRS iBV, Nice, France
推荐引用方式 GB/T 7714	Esteve, D.,Boulet, N.,Belles, C.,et al. Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells[J]. NATURE COMMUNICATIONS,2019,10.
APA	Esteve, D..,Boulet, N..,Belles, C..,Zakaroff-Girard, A..,Decaunes, P..,...&Galitzky, J..(2019).Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells.NATURE COMMUNICATIONS,10.
MLA	Esteve, D.,et al."Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells".NATURE COMMUNICATIONS 10(2019).