Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-04409-z |
Nanowire arrays restore vision in blind mice | |
Tang, Jing1; Qin, Nan1; Chong, Yan1; Diao, Yupu1; Yiliguma1; Wang, Zhexuan1; Xue, Tian2; Jiang, Min1; Zhang, Jiayi1; Zheng, Gengfeng1 | |
2018-03-06 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | The restoration of light response with complex spatiotemporal features in retinal degenerative diseases towards retinal prosthesis has proven to be a considerable challenge over the past decades. Herein, inspired by the structure and function of photoreceptors in retinas, we develop artificial photoreceptors based on gold nanoparticle-decorated titania nanowire arrays, for restoration of visual responses in the blind mice with degenerated photoreceptors. Green, blue and near UV light responses in the retinal ganglion cells (RGCs) are restored with a spatial resolution better than 100 mu m. ON responses in RGCs are blocked by glutamatergic antagonists, suggesting functional preservation of the remaining retinal circuits. Moreover, neurons in the primary visual cortex respond to light after subretinal implant of nanowire arrays. Improvement in pupillary light reflex suggests the behavioral recovery of light sensitivity. Our study will shed light on the development of a new generation of optoelectronic toolkits for subretinal prosthetic devices. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000426657700002 |
WOS关键词 | RETINAL GANGLION-CELLS ; VISUAL FUNCTION ; MOUSE RETINA ; SOLAR-CELLS ; PHOTORECEPTORS ; LIGHT ; NANOPARTICLES ; IMPLANTATION ; MELANOPSIN ; PROSTHESIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203819 |
专题 | 资源环境科学 |
作者单位 | 1.Fudan Univ, Zhongshan Hosp, Dept Ophthalmol,Shanghai Key Lab Mol Catalysis &, Lab Adv Mat,Inst Brain Sci,State Key Lab Med Neur, Shanghai 200032, Peoples R China; 2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China; 3.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Tang, Jing,Qin, Nan,Chong, Yan,et al. Nanowire arrays restore vision in blind mice[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Tang, Jing.,Qin, Nan.,Chong, Yan.,Diao, Yupu.,Yiliguma.,...&Zheng, Gengfeng.(2018).Nanowire arrays restore vision in blind mice.NATURE COMMUNICATIONS,9. |
MLA | Tang, Jing,et al."Nanowire arrays restore vision in blind mice".NATURE COMMUNICATIONS 9(2018). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论