GSTDTAP  > 资源环境科学
DOI10.1038/s41467-018-04409-z
Nanowire arrays restore vision in blind mice
Tang, Jing1; Qin, Nan1; Chong, Yan1; Diao, Yupu1; Yiliguma1; Wang, Zhexuan1; Xue, Tian2; Jiang, Min1; Zhang, Jiayi1; Zheng, Gengfeng1
2018-03-06
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2018
卷号9
文章类型Article
语种英语
国家Peoples R China
英文摘要

The restoration of light response with complex spatiotemporal features in retinal degenerative diseases towards retinal prosthesis has proven to be a considerable challenge over the past decades. Herein, inspired by the structure and function of photoreceptors in retinas, we develop artificial photoreceptors based on gold nanoparticle-decorated titania nanowire arrays, for restoration of visual responses in the blind mice with degenerated photoreceptors. Green, blue and near UV light responses in the retinal ganglion cells (RGCs) are restored with a spatial resolution better than 100 mu m. ON responses in RGCs are blocked by glutamatergic antagonists, suggesting functional preservation of the remaining retinal circuits. Moreover, neurons in the primary visual cortex respond to light after subretinal implant of nanowire arrays. Improvement in pupillary light reflex suggests the behavioral recovery of light sensitivity. Our study will shed light on the development of a new generation of optoelectronic toolkits for subretinal prosthetic devices.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000426657700002
WOS关键词RETINAL GANGLION-CELLS ; VISUAL FUNCTION ; MOUSE RETINA ; SOLAR-CELLS ; PHOTORECEPTORS ; LIGHT ; NANOPARTICLES ; IMPLANTATION ; MELANOPSIN ; PROSTHESIS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/203819
专题资源环境科学
作者单位1.Fudan Univ, Zhongshan Hosp, Dept Ophthalmol,Shanghai Key Lab Mol Catalysis &, Lab Adv Mat,Inst Brain Sci,State Key Lab Med Neur, Shanghai 200032, Peoples R China;
2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China;
3.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
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Tang, Jing,Qin, Nan,Chong, Yan,et al. Nanowire arrays restore vision in blind mice[J]. NATURE COMMUNICATIONS,2018,9.
APA Tang, Jing.,Qin, Nan.,Chong, Yan.,Diao, Yupu.,Yiliguma.,...&Zheng, Gengfeng.(2018).Nanowire arrays restore vision in blind mice.NATURE COMMUNICATIONS,9.
MLA Tang, Jing,et al."Nanowire arrays restore vision in blind mice".NATURE COMMUNICATIONS 9(2018).
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