Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-018-04687-7 |
Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes | |
Burguera, Demian1; 39;Agostino, Ylenia2; 39;Aniello, Salvatore3 | |
2017-11-27 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain; Italy; USA; England |
英文摘要 | Epithelial-mesenchymal interactions are crucial for the development of numerous animal structures. Thus, unraveling how molecular tools are recruited in different lineages to control interplays between these tissues is key to understanding morphogenetic evolution. Here, we study Esrp genes, which regulate extensive splicing programs and are essential for mammalian organogenesis. We find that Esrp homologs have been independently recruited for the development of multiple structures across deuterostomes. Although Esrp is involved in a wide variety of ontogenetic processes, our results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-to-epithelial transitions in deuterostome ancestors. However, consistent with the extensive rewiring of Esrp-dependent splicing programs between phyla, most developmental defects observed in vertebrate mutants are related to other types of morphogenetic processes. This is likely connected to the origin of an event in Fgfr, which was recruited as an Esrp target in stem chordates and subsequently co-opted into the development of many novel traits in vertebrates. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000416293600015 |
WOS关键词 | TO-MESENCHYMAL TRANSITION ; GENE REGULATORY NETWORKS ; NERVOUS-SYSTEM ; CIONA-INTESTINALIS ; SENSORY NEURONS ; LIGAND-BINDING ; GROWTH ; CELLS ; VERTEBRATE ; EXPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/203833 |
专题 | 资源环境科学 |
作者单位 | 1.Barcelona Inst Sci & Technol, Ctr Genom Regulat, Dr Aiguader 88, Barcelona 08003, Spain; 2.Univ Barcelona, Sch Biol, Dept Genet, Diagonal 643, Barcelona 08028, Spain; 3.Univ Barcelona, Inst Biomed IBUB, Diagonal 643, Barcelona 08028, Spain; 4.Univ Pompeu Fabra, Barcelona 08003, Spain; 5.Stz Zool Anton Dohrn, Villa Comunale, I-80121 Naples, Italy; 6.NYU, Ctr Dev Genet, Dept Biol, New York, NY 1003 USA; 7.CSIC, Inst Biol Mol Barcelona, Parc Cient Barcelona,Baldiri Reixac 20, Barcelona 08028, Spain; 8.Nat Hist Museum London, Dept Life Sci, Cromwell Rd, London SW7 5BD, England |
推荐引用方式 GB/T 7714 | Burguera, Demian,39;Agostino, Ylenia,39;Aniello, Salvatore. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes[J]. NATURE COMMUNICATIONS,2017,8. |
APA | Burguera, Demian,39;Agostino, Ylenia,&39;Aniello, Salvatore.(2017).Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes.NATURE COMMUNICATIONS,8. |
MLA | Burguera, Demian,et al."Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes".NATURE COMMUNICATIONS 8(2017). |
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