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DOI | 10.1038/s41467-019-09592-1 |
Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells | |
Enamorado, Michel1; Iborra, Salvador1; Priego, Elena1,2; Cueto, Francisco J.1,2; Quintana, Juan A.1; Martinez-Cano, Sarai1; Mejias-Perez, Ernesto3; Esteban, Mariano3; Melero, Ignacio4,5,6; Hidalgo, Andres1,7; Sancho, David1 | |
2019-04-04 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain; Germany |
英文摘要 | The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8(+) T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8(+) T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8(+) T cells subsets needed for optimal tumour vaccination and immunotherapy. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000405682100001 |
WOS关键词 | TUMOR-INFILTRATING LYMPHOCYTES ; CD8-ALPHA(+) DENDRITIC CELLS ; TISSUE-RESIDENT ; NONLYMPHOID TISSUE ; INFECTION ; REVEALS ; EXPRESSION ; MIGRATION ; RESPONSES ; PATTERNS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204300 |
专题 | 资源环境科学 |
作者单位 | 1.Ctr Nacl Invest Cardiovasc Carlos III CNIC, Melchor Fernandez Almagro,3, Madrid 28029, Spain; 2.Univ Autonoma Madrid, Arzobispo Morcillo 4, Madrid 28029, Spain; 3.CSIC, CNB, Dept Mol & Cellular Biol, Darwin 3, Madrid 28049, Spain; 4.Ctr Invest Biomed Red Canc CIBERONC, Ctr Appl Med Res CIMA, Div Immunol & Immunotherapy, Pamplona 31008, Spain; 5.Univ Navarra, Univ Clin, Pio 12,55, Pamplona 31008, Spain; 6.Inst Invest Sanitaria Navarra IdISNA, Pio 12,55, Pamplona 31008, Spain; 7.Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent IPEK, Pettenkoferstr 9, D-80336 Munich, Germany |
推荐引用方式 GB/T 7714 | Enamorado, Michel,Iborra, Salvador,Priego, Elena,et al. Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Enamorado, Michel.,Iborra, Salvador.,Priego, Elena.,Cueto, Francisco J..,Quintana, Juan A..,...&Sancho, David.(2019).Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells.NATURE COMMUNICATIONS,8. |
MLA | Enamorado, Michel,et al."Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells".NATURE COMMUNICATIONS 8(2019). |
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