GSTDTAP  > 资源环境科学
DOI10.1038/s41467-019-09592-1
Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells
Enamorado, Michel1; Iborra, Salvador1; Priego, Elena1,2; Cueto, Francisco J.1,2; Quintana, Juan A.1; Martinez-Cano, Sarai1; Mejias-Perez, Ernesto3; Esteban, Mariano3; Melero, Ignacio4,5,6; Hidalgo, Andres1,7; Sancho, David1
2019-04-04
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2017
卷号8
文章类型Article
语种英语
国家Spain; Germany
英文摘要

The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8(+) T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8(+) T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8(+) T cells subsets needed for optimal tumour vaccination and immunotherapy.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000405682100001
WOS关键词TUMOR-INFILTRATING LYMPHOCYTES ; CD8-ALPHA(+) DENDRITIC CELLS ; TISSUE-RESIDENT ; NONLYMPHOID TISSUE ; INFECTION ; REVEALS ; EXPRESSION ; MIGRATION ; RESPONSES ; PATTERNS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/204300
专题资源环境科学
作者单位1.Ctr Nacl Invest Cardiovasc Carlos III CNIC, Melchor Fernandez Almagro,3, Madrid 28029, Spain;
2.Univ Autonoma Madrid, Arzobispo Morcillo 4, Madrid 28029, Spain;
3.CSIC, CNB, Dept Mol & Cellular Biol, Darwin 3, Madrid 28049, Spain;
4.Ctr Invest Biomed Red Canc CIBERONC, Ctr Appl Med Res CIMA, Div Immunol & Immunotherapy, Pamplona 31008, Spain;
5.Univ Navarra, Univ Clin, Pio 12,55, Pamplona 31008, Spain;
6.Inst Invest Sanitaria Navarra IdISNA, Pio 12,55, Pamplona 31008, Spain;
7.Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent IPEK, Pettenkoferstr 9, D-80336 Munich, Germany
推荐引用方式
GB/T 7714
Enamorado, Michel,Iborra, Salvador,Priego, Elena,et al. Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells[J]. NATURE COMMUNICATIONS,2019,8.
APA Enamorado, Michel.,Iborra, Salvador.,Priego, Elena.,Cueto, Francisco J..,Quintana, Juan A..,...&Sancho, David.(2019).Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells.NATURE COMMUNICATIONS,8.
MLA Enamorado, Michel,et al."Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells".NATURE COMMUNICATIONS 8(2019).
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