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DOI | 10.1073/pnas.1802479115 |
Optimizing the impact of low-efficacy influenza vaccines | |
Sah, Pratha1; Medlock, Jan2; Fitzpatrick, Meagan C.1,3; Singer, Burton H.4; Galvani, Alison P.1 | |
2018-05-15 | |
发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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ISSN | 0027-8424 |
出版年 | 2018 |
卷号 | 115期号:20页码:5151-5156 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The efficacy of influenza vaccines varies from one year to the next, with efficacy during the 2017-2018 season anticipated to be lower than usual. However, the impact of low-efficacy vaccines at the population level and their optimal age-specific distribution have yet to be ascertained. Applying an optimization algorithm to a mathematical model of influenza transmission and vaccination in the United States, we determined the optimal age-specific uptake of low-efficacy vaccine that would minimize incidence, hospitalization, mortality, and disability-adjusted life-years (DALYs), respectively. We found that even relatively low-efficacy influenza vaccines can be highly impactful, particularly when vaccine uptake is optimally distributed across age groups. As vaccine efficacy declines, the optimal distribution of vaccine uptake shifts toward the elderly to minimize mortality and DALYs. Health practitioner encouragement and concerted recruitment efforts are required to achieve optimal coverage among target age groups, thereby minimizing influenza morbidity and mortality for the population overall. |
英文关键词 | mathematical model age structured vaccination DALY hospitalization |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000432120400048 |
WOS关键词 | IMMUNIZATION PRACTICES ; VACCINATION DECISIONS ; ADVISORY-COMMITTEE ; SEASONAL INFLUENZA ; RANDOMIZED-TRIAL ; UNITED-STATES ; RECOMMENDATIONS ; PREVENTION ; DISEASES ; VIRUSES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204917 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Yale Sch Publ Hlth, Ctr Infect Dis Modeling & Anal, New Haven, CT 06510 USA; 2.Oregon State Univ, Dept Biomed Sci, Corvallis, OR 97331 USA; 3.Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA; 4.Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32610 USA |
推荐引用方式 GB/T 7714 | Sah, Pratha,Medlock, Jan,Fitzpatrick, Meagan C.,et al. Optimizing the impact of low-efficacy influenza vaccines[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2018,115(20):5151-5156. |
APA | Sah, Pratha,Medlock, Jan,Fitzpatrick, Meagan C.,Singer, Burton H.,&Galvani, Alison P..(2018).Optimizing the impact of low-efficacy influenza vaccines.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,115(20),5151-5156. |
MLA | Sah, Pratha,et al."Optimizing the impact of low-efficacy influenza vaccines".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115.20(2018):5151-5156. |
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