Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1330 |
Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study | |
Manzano-Salgado, Cyntia B.1,2,3; Casas, Maribel1,2,3; Lopez-Espinosa, Maria-Jose2,4; Ballester, Ferran2,4; Iniguez, Carmen2,4; Martinez, David1,2,3; Romaguera, Dora5,6; Fernandez-Barres, Silvia1,2,3; Santa-Marina, Loreto2,7,8; Basterretxea, Mikel2,7,8; Schettgen, Thomas9; Valvi, Damaskini1,2,3,10; Vioque, Jesus2,11; Sunyer, Jordi1,2,3; Vrijheid, Martine1,2,3 | |
2017-09-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:9 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain; Germany; USA |
英文摘要 | BACKGROUND: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, hut evidence is scarce and inconsistent. OBJECTIVES: We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM risk score. METHODS: We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester). We assessed weight gain from birth until 6 mo. At 4 and 7 y, we calculated the age- and sex-specific z-scores for BMI, waist circumference (WC), and blood pressure (BP) (n approximate to 1,000). At age 4, we calculated the age-, sex-, and region specific z-scores for cholesterol, triglycerides (TGs), high-density (HDL-C), and low-density lipoprotein cholesterol (LDL-C) (n = 627). At age 4, we calculated a CM-risk score (n = 386) as the sum of the individual age-, sex-, and region-specific z-scores for WC, BP, HDL-C, and TGs. We used the average between the negative of HDE-C z-score and TGs z-score to give similar weight to lipids and the other components in the score. A higher score indicates a higher cardiometaholic risk at age 4. RESULTS: PFOS and PFOA were the most abundant PFAS (geometric mean: 5.80 and 2.32 ng/mL respectively). In general, prenatal PFAS concentrations were not associated with individual outcomes or the combined CM-risk score. Exceptions were positive associations between prenatal PFHxS and TGs z-score [for a doubling of exposure, beta = 0.11; 95% confidence interval (CI): 0.01, 0.21], and between PFNA and the CM-risk score (beta=0.60; 95% CI: 0.04, 1.16). There was not clear or consistent evidence of modification by sex. CONCLUSIONS: We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413792800028 |
WOS关键词 | METABOLIC SYNDROME SCORE ; BLOOD-PRESSURE ; SERUM-LIPIDS ; PERFLUORINATED CHEMICALS ; PERFLUOROOCTANOIC ACID ; RAPID GROWTH ; ASSOCIATION ; CHILDHOOD ; OVERWEIGHT ; ADIPOSITY |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22589 |
专题 | 资源环境科学 |
作者单位 | 1.ISGlobal, Ctr Res Environm Epidemiol CREAL, Doctor Aiguader 8808003, Barcelona, Catalonia, Spain; 2.Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain; 3.Univ Pompeu Fabra, Barcelona, Spain; 4.Univ Valencia, Univ Jaume I, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain; 5.Univ Hosp Son Espases, Hlth Res Inst Palma IdISPa, Palma de Mallorca, Spain; 6.Spanish Consortium Res Obes & Nutr CIBEROBN, Madrid, Spain; 7.Publ Hlth Dept Gipuzkoa, San Sebastian, Spain; 8.Hlth Res Inst BIODONOSTIA, San Sebastian, Spain; 9.Rhein Westfal TH Aachen, Inst Occupat Med, Aachen, Germany; 10.Harvard TH Chan Sch Publ Hlth, Boston, MA USA; 11.Miguel Hernandez Univ, Alacant, Spain |
推荐引用方式 GB/T 7714 | Manzano-Salgado, Cyntia B.,Casas, Maribel,Lopez-Espinosa, Maria-Jose,et al. Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(9). |
APA | Manzano-Salgado, Cyntia B..,Casas, Maribel.,Lopez-Espinosa, Maria-Jose.,Ballester, Ferran.,Iniguez, Carmen.,...&Vrijheid, Martine.(2017).Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(9). |
MLA | Manzano-Salgado, Cyntia B.,et al."Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.9(2017). |
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